First Overall Pick NFL Draft Predictions & Odds 2021

  • Clemson standout Quarterback Trevor Lawrence is highly favored to be selected first
  • Four out of the top five favorites for this honor played under center for their team
  • Former Oregon Duck Penei Sewell is the only offensive tackle to crack the top five

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First Overall Pick Odds 2021

Odds taken 27 April 2021 from DraftKings Sportsbook

Player/University Odds
Trevor Lawrence, Clemson QB -10000
Zach Wilson, BYU QB +1600
Justin Fields, Ohio State University QB +3300
Penei Sewell, University of Oregon OT +6600
Trey Lance, North Dakota State QB +8000

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First Overall Pick Predictions and Picks

Jaguars’ new head coach Urban Meyer will no doubt want the best college quarterback available, which is by far is the once-in-a-lifetime talent named Trevor Lawrence.


Trevor Lawrence (-10000)

How to Watch NFL Draft 2021/2022

NFL Draft Information
What NFL Draft 2021/2022
Where Cleveland, Ohio
When Thu, April 29 thru Sat May 1, 2021;
How to watch NFL Network/ESPN

Favorites to Win First Overall Pick

Trevor Lawrence, Clemson QB

3x ACC Champion and last season’s ACC Player of the year, this National Champion winner and MVP (2018) is the highly favored first overall pick by a longshot.

With the size of a big leaguer, the 6’6” 220 pounds Lawrence completed 66 percent of his passes in three seasons for over 10,000 yards, 90 touchdowns, and just 17 interceptions total, numbers that have had pro scouts looking his way since 2018.

No matter what mock draft you look at, Lawrence is the guy who will be selected first overall.

Zach Wilson, BYU QB

A twenty-one-year-old quarterback who completed 67.6 percent of his passes in three seasons at BYU for 7,652 yards and 56 touchdowns with just 15 interceptions.

Wilson has brought his team to a bowl game every season he has been under center and was named offensive MVP of the 2020 Boca Raton Bowl after completing 26-of-34 passes for 425 yards and 3 TDs.

Some mock drafts have Wilson going to the New York Jets with the second overall pick, a team that seems ready to move on from current starter Sam Darnold.

Justin Fields, Ohio State University QB

A Heisman Trophy finalist and a 2x first-team All-Big Ten player who led his Buckeyes to the 2021 College Football Championship.

Fields had started his college career as a Georgia Bulldog but transferred to OSU and started under center during the 2019 and 2020 seasons, with a completion percentage of 68 and a career rating of 178.8, don’t count this underdog out of the running.

Some mock drafts have Fields going to the Atlanta Falcons with the fourth overall pick, a team that cannot seem to return to the big game no matter how great QB Matt Ryan plays.

No Chance to Win

Penei Sewell, University of Oregon OT

A 6’ 6” 325-pound offensive tackle born in Malaeimi, a small town in American Samoa, Sewell certainly has the skills and football IQ to be a first overall pick, but this one will be more about need than talent.

Jacksonville needs a QB, so unless they are willing to do a last-minute trade deal with another franchise with O-line needs, the highly sought-after Penei has little or no chance to snag this honor, though he will most likely be taken somewhere in the first round.

Some mock drafts have Sewell going third to the Dolphins, who could definitely use some help up front.

Caleb Farley, Virginia Tech CB

At the very end of the oddsmakers list of potential first overall picks is longshot Caleb Farley, the talented cornerback who converted from being a receiver and played for Virginia Tech, though he missed the 2017 season due to a knee injury.

He finished 2018 with 36 tackles, 2 interceptions, and a sack for VT and was named first-team All-ACC the next season after posting 20 tackles, four interceptions, and a touchdown.

Farley sat out the 2020 season due to the coronavirus pandemic and spent the year preparing for the NFL Draft and with his talent chances are he will be selected, but first overall looks out of reach for this exciting playmaker right now.

Some mocks have Farley going to the Broncos with the 13th pick overall, with the secondary being a big area in their defense that could use improvement.

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Mike Lukas

Expert on NFL

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]