When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

Los Angeles Rams vs San Francisco 49ers Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
12 min read
Rams Vs 49ers 2020 10 18
  • The Los Angeles Rams go into Week 6 much healthier than their opponents
  • After 49ers QB Jimmy Garoppolo was sacked 3 times in the first half he was benched
  • Last season, the 49ers beat the Rams twice, first by a score of 20-7, then by 34-31

Rams vs 49ers Odds

Check out the latest odds for Rams vs 49ers game, here! For more NFL predictions and picks check back with WSN every day!

Team Point Spread Odds
Los Angeles Rams -3.5
BET NOW
-110
BET NOW
San Francisco 49ers +3.5
BET NOW
-110
BET NOW

 

Odds from DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or check out more offers and promo codes for the best online sportsbooks.

Rams vs 49ers Predictions and Picks

Tough to imagine a way for this banged-up Niners squad to pull it together enough to beat the far healthier Rams, especially given how well QB Jared Goff is beginning to play.

Pick:

Rams -3.5 (-110)

How to Watch Rams vs 49ers

Rams vs 49ers Information
What Los Angeles Rams vs San Francisco 49ers
Where Levi’s Stadium in Santa Clara, CA
When Sun, October 18, 2020; 8:20 PM ET
How to watch NBC

It is a 4-1 Los Angeles Rams that arrives in Week 6, one with a fifth-ranked offense and a fourth-ranked defense, so they should make easy work of this banged-up 49ers team that isn’t even sure of their starting QB, whereas the Rams quarterback Jared Goff has a completion percentage of 71.7, ranked fourth among his peers.

According to San Francisco 49ers head coach Kyle Shanahan, he benched starting QB Jimmy Garoppolo and played his backup C.J. Beathard in the second half to protect Jimmy after he was sacked three times in the first half, although the seven points his offense managed during that time might have also played a part

These two NFC West rivals have met each other a total of 141 times (including 1 postseason game), with the San Francisco 49ers winning 71 of those games and the Los Angeles Rams winning 67 of them, with 3 ties thrown into that mix.

Can the Rams Continue to Show Up on Both Sides of the Ball?

The Rams are solid on both sides of the ball, with OC Kevin O’Connell and DC Brandon Staley coaching top-five squads that are tough to game plan around.

O’Connell’s offense averages 403 total yards and 27.2 points per game, while Staley’s defense keeps opponents to 304 total yards and just 18 points per game, together with a great formula for winning.

Against this injured San Francisco team, these Rams just have to show up and do what they do, nothing more, and they should be able to find themselves on the winning side of the field.

Can the Battered 49ers Find Victory in This Must Win NFC West Matchup?

A half dozen 49ers are listed as questionable for this game, mostly on defense, with LB Kwon Alexander (ankle) and CBs Dontae Johnson (groin) and Ken Webster (hamstring) making them vulnerable in the secondary.

QB Jimmy Garoppolo is also listed as questionable due to his ongoing ankle situation, so it might be a good idea for his backup, C.J. Beathard, to get ready to see some more action in Week 6.

There are sixteen Niners on injured reserve right now, so this team is fielding the best of their next men up, and that makes it a whole lot easier to think about beating this physically damaged team who, only a season ago, were the NFC champs.

Rams Key Player: (WR) Robert Woods

One of QB Jared Goff’s favorite targets these days is Robert Woods, a receiver in his eighth NFL season, fourth with the Rams, and following up a 1,100+ passing yards season in 2019 that followed a 1,200+ season in 2018.

This year, Woods is on track to do the same, so far with 23 catches for 300 yards and 2 touchdowns, a sure-handed receiver who is a constant threat to go deep and who can get yards after the catch with his size (6’ 0”, 195lb).

Woods will be a key target in this Week 6 matchup with San Francisco, so look for him to follow up his 4-catch, 71 yards, and a touchdown Week 5 with some more impressive output.


Editor’s Picks


49ers Key Player: (QB) C.J. Beathard

This is C.J. Beathard’s third NFL season, all with the 49ers, and it may be his big chance to get some serious reps now that Garoppolo is officially listed as questionable for Week 6 due to that injured ankle.

Beathard only completed half of his passes in the team’s loss to the Dolphins in Week 5, though he did throw for a touchdown and avoided tossing any interceptions, a total glass half full look at the losing quarterback in that matchup.

The main problem Beathard will be facing in Week 6 is named Aaron Donald, the Rams powerful defensive tackle who is currently leading the league in sacks with 7.5 of them, something C.J. and his front line should definitely keep in mind.

Best Promo Codes and Bonuses for Rams vs 49ers Week 6

Best sportsbooks for betting on Rams vs 49ers in your state:

Feeling lucky? Sign-up to our NFL Pick’em Contest and get a chance to win a $200 Amazon voucher.

Bet on NFL with the best NJ sportsbooks!

Bet on NFL with the best Indiana sportsbooks!

Bet on NFL with the best PA sportsbooks!

Image for Mike Lukas

AUTHOR

Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

More info on Mike Lukas
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork

© Rebel Penguin ApS 2024 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.