Atletico San Luis vs. Cruz Azul Prediction: La Maquina Kick off Title Defence

Friday evening, the reigning Liga MX champions, Cruz Azul, will open their campaign on the road, travelling to Estadio Alfonso Lastras to take on Atlético San Luis. La Maquina have won 13 of the previous 20 encounters in this matchup. 

• Cruz Azul won its 10th league title by claiming the 2026 Clausura

• Atletico San Luis finished the previous campaign in 14th place

Here, we will break down the betting odds and share our favourite picks for Atletico San Luis vs. Cruz Azul.

Atletico San Luis vs. Cruz Azul Betting Odds for Friday, July 17

The odds suggest both teams are expected to score. The Both Teams to Score Yes market is priced at -165, while No is available at +115.

Atletico San Luis vs. Cruz Azul Betting Odds

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Atletico San Luis vs. Cruz Azul Betting Prediction

The previous meeting is not expected to be the same scoreline as Cruz Azul won 3-0 during the previous term. Now it’s time to find the best betting value and top picks.

Atletico San Luis Preview

The Diego Mejía era starts in San Luis as he takes over as the new manager this upcoming season. Mejía's last employer was Atletico Ottawa of the Canadian Premier League, but he has also worked in Liga MX, managing FC Juárez for 28 matches. 

João Pedro once again is expected to be the primary source of the team’s attacking threat. Last season, the 34-year-old striker amassed 14 goals, making him the league’s most potent player and earning him the Golden Boot. Rafa Llorente was the club's marquee move of the summer, as they hope the winger's ball control can help break the lines and create more offence.

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Cruz Azul Preview

This summer, the interim title was removed from Joel Huiqui’s credentials, and he officially became the manager. The promotion was well deserved as he helped lead La Maquina to their first league crown in five years. Heading into the 2026 Apertura regular tournament, the winning side had retained most of its members who were integral to last season's success. 

Last summer's monster signing of José Paradela paid off; between the regular season and playoffs, the attacking midfielder finished with 12 goal contributions. Along with Agustín Palavecino, Carlos Rodriguez and Carlos Rotondi patrolling the middle of the park, Cruz Azul possesses one of the deepest midfield groups in Liga MX, with the class to control the tempo or create space to attack.

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Atletico San Luis vs. Cruz Azul- My Pick

• Atletico San Luis vs. Cruz Azul pick: Both teams to score Yes (-165) at DraftKings

Friday’s affair has solid potential with both sides featuring on the scoreboard, with a 62 percent implied probability of occurring. When these two contestants lock horns at the Estadio Alfonso Lastras, both teams can get on the scoresheet, as seven of the previous nine matches resulted in both teams scoring. Last season, during the regular campaign, at least 65 percent of matches involving each of these clubs featured both teams finding the back of the net, reinforcing the expectation of another both teams to score outcome on Friday.

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How to Watch Atletico San Luis vs. Cruz Azul

• When: July 17, 9 pm ET 

• Where: Estadio Alfonso Lastras

• TV: Univision, DirecTV Stream, ViX