Tigres UANL vs. Cruz Azul Prediction: A Slim Two-Point Gap Divides the Heavyweight Duel

• Tigres UANL continue to accumulate results, unbeaten in their last seven 

• Cruz Azul suffered its first setback in the 2025 Apertura 

Saturday evening, Tigres UANL welcomes Cruz Azul to Estadio Universitario for a crucial fixture in round 12. The most recent encounter occurred during the 2025 CONCACAF Champions Cup, which saw La Máquina win 1-0.

Here, we will break down the betting odds and share our favourite picks for Tigres UANL vs. Cruz Azul.

Tigres UANL vs. Cruz Azul betting odds for Saturday, October 4

The draw no bet market has pinned the home side to win at -163 or a draw, resulting in a return stake. The exact scenario for Cruz Azul is listed at +120.

Tigres UANL vs. Cruz Azul Odds

The odds for Tigres UANL vs. Cruz Azul can be found in the odds table below, courtesy of bet365 sportsbook. Sign up for a bet365 account with our promo code WSN365 and claim the welcome offer: Bet $5, Get $200 in Bonus Bets Win or Lose.

Tigres UANL vs. Cruz Azul Betting Prediction

Tigres UANL Preview

Guido Pizarro’s crew continue to deposit points to their season tally, as they currently sit with 22, placing them fifth overall. On Sunday, Tigres dominated their counterpart, Querétaro, defeating them 2-0. Los Tigres de México controlled most of the pace inside the 90-minute frame, retaining 70 percent of the possession while amassing 20 shots toward the target. 

Juan Brunetta was one of the goal scorers on Sunday, chalking up his third this term. The talented central midfielder is slightly off last season's stride, where he acquired 10 goal contributions. Both Correa and Herrera share the team lead in goals, registering four goals apiece. Look for the pair to be lively on the pitch on Saturday as they have combined for 48 shots on target.

Bet $5 at bet365 and Get $200 in Bonus Bets

Cruz Azul Preview

Over the weekend, Nicolás Larcamón’s men tasted defeat for the first time in Liga MX, suffering a 2-0 defeat against Club Tijuana. The match was altered moments after the opening whistle, due to Jorge Rodarte picking up a red card in the fifth minute. You have to go back to the 7-0 drubbing against the Seattle Sounders during this year's Leagues Cup, the last time La Máquina lost. 

Coming off the bench as a substitute in recent outings, Angel Sepulveda will look to halt his cold streak. The veteran forward has gone six straight appearances without finding the back of the net. Though it’s been a while since he’s celebrated a goal, Sepulveda still leads his team in the goal department, cataloging five goals through 10 games.

Get $200 in Bonus Bets When Betting $5 at bet365

Tigres UANL vs. Cruz Azul - My Pick

• Tigres UANL vs. Cruz Azul pick: Cruz Azul draw no bet (+120) at bet365

Saturday’s tilt is a clash between two sides who have yet to go through much turmoil in the opening 11 league matches. We feel the visitors have a decent shot to avoid a defeat and to walk into enemy territory and claim all three points. Cruz Azul has played above par when travelling to Estadio Universitario, only losing six out of their previous 20 trips. In terms of goals conceded per match, it’s a battle of the best defence (Tigres) against Cruz Azul, who rank sixth in the Mexican top-flight. This should be a closely contested battle where both sides are chasing down Toluca for that first-place overall position in the standings.

Claim $200 in Bonus Bets at bet365 With a $5 Wager

How to Watch Tigres UANL vs. Cruz Azul

• When: October 4, 9 p.m. ET

• Where: Estadio Universitario

• TV: Telemundo, Universo, Fubo, DirecTV Stream, Peacock Premium