MLS All-Star Game: MLS vs. Liga MX Prediction, Betting Odds and Picks

• The 29th annual MLS All-Star Game will take place at Q2 Stadium in Austin, Texas

• This will be the fourth edition of MLS clashing against Liga MX in an All-Star match 

Wednesday evening at the home of Austin FC, the best from MLS will collide against the top stars from Mexico’s top-flight division, Liga MX. The most recent matchup between them occurred in last year's All-Star game, which saw Liga MX throttle MLS, winning 4-1 at Lower.com Field in Columbus, Ohio. 

Here, we will break down the betting odds and share our favourite picks for MLS vs. Liga MX.

MLS vs. Liga MX Betting Odds for Wednesday, July 23

Wednesday’s All-Star clash is anybody’s game with the materialized odds produced by the books in the moneyline 3-way market. MLS and Liga MX are priced at +130 to win inside the 90-minute contest. If both clubs are level after the full-time whistle, the draw is listed at +310. 

MLS vs. Liga MX Odds

The following odds are taken from bet365 Sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose.

MLS vs. Liga MX Betting Predictions 

MLS Preview

Austin FC Head Coach Nico Estévez takes the reins for MLS on the touch line Wednesday evening. The Spaniard coach will have many quality options regarding who will see the pitch in the 29th annual All-Star game. 

Plenty of attacking prowess up top for team MLS with Lionel Messi and the resurgence of Sam Surridge from Nashville SC. Leading the line upfront in the All-Star game, both sets of forwards have obtained 18 goals in the MLS campaign, which sees both players tied at the top of the scoring category. 

A rising star who performed with hustle and determination during the 2025 CONCACAF Gold Cup for the United States, Diego Luna will be heavily relied upon. The creative midfielder will look to add to his resume with an impressive outing on Wednesday, which could help him see his name called to the U.S. roster in next year’s World Cup. In 19 MLS outings in 2025, the 21-year-old has collected nine goals and two assists.

Bet $5 at bet365 and Get $150 in Bonus Bets

Liga MX Preview

Winning coach of the year in Liga MX, Andre Jardine of Club América, will lead the best-selected group from Mexico for the second straight year. Unlike its counterparts, Liga MX almost brought in every player from performance-based showings rather than fan-voted spots like MLS. 

Though it’s an exhibition match, you can bet defender Sergio Ramos will play his heart out in what could be the 39-year-old's last participation representing Liga MX. Regarded as one of the best defenders to grace the pitch, the Rayados’ product will be a load for MLS to deal with, with his impressive duels, winning 63.6 percent of them. 

Liga MX is bringing the potential future of the Mexican men’s national program to Austin, Texas. Alexis Vega shone for El Tri during the Gold Cup, and in the previous Liga MX campaign, the Toluca star amassed 13 goals and 11 assists. 16-year-old Gilberto Mora already has over 1500 minutes of play under his belt in Liga MX with Tijuana. Mora’s outstanding passing skills could be spotlighted in the All-Star game. 

Get $150 in Bonus Bets When Betting $5 at bet365

MLS vs. Liga MX - My Pick

• MLS vs. Liga MX pick: Liga MX Moneyline 3-way (+130) at bet365 

Best on best can be tricky to determine who will come out on top. That said, we feel Liga MX edges out MLS regarding quality and depth. This crop of Liga MX All-Stars had seven representatives who won the Gold Cup with Mexico, helping them win their 10th title. Liga MX has brought in five Cruz Azul players, who won this year’s CONCACAF Champions Cup over the Vancouver Whitecaps. Yes, MLS possesses World Cup and UEFA Champions League winners on its squad, but their aging players are already two-thirds in their gruelling season, while Liga MX players are much fresher, just coming off a mid-summer break a few weeks ago. 

Claim $150 in Bonus Bets at bet365 With a $5 Wager

How to Watch MLS vs. Liga MX

• When: July 23, 9 p.m. ET

• Where: Q2 Stadium 

• TV: Apple TV, MLS Season Pass, Amazon Prime Video, Xfinity