Inter Miami CF vs. Nashville SC Prediction: Messi and Teammates Launch Campaign for League Crown

• Inter Miami CF are the higher seed as they finished third overall in the East with 65 points 

• Nashville SC has a chance to add another trophy to its cabinet as it won this year’s U.S. Open Cup

The best-of-three series kicks off Friday evening with Nashville confronting Inter Miami down at Chase Stadium. These two are fresh off their duel, which saw them lock horns on Decision Day, with the Herons walking away with three points in a seven-goal barnburner, winning 5-2.

Here, we will break down the betting odds and share our favourite picks for Inter Miami CF vs. Nashville SC.

Inter Miami CF vs. Nashville SC Betting Odds for Friday, October 24

The Asian Handicap market spotlights the hosts as the favourites, as Inter Miami CF -1 are listed at -137 while Nashville +1 is priced at +110.

Inter Miami CF vs. Nashville SC Odds

The following odds are taken from BetRivers sportsbook. Claim your bonus at BetRivers: $100 Bonus Bet.

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Inter Miami CF vs. Nashville SC Betting Prediction

Inter Miami CF Preview

Missing an MLS Cup from the trophy cabinet, Javier Mascherano’s troops will begin their journey towards their end goal on Friday. Finishing third in the Eastern Conference with 65 points obtained, it’s nine points off last year’s output in the standings. The Herons will attempt to erase last year’s playoff debacle, which saw them get overthrown by ninth-seeded Atlanta United during the first round. 

Inter Miami will mostly stick to a similar lineup that was trotted out last weekend, which managed to cultivate five goals. Yet again, Lionel Messi fulfilled another commanding performance, which saw him score a hat-trick and an assist. His three-goal display ensured the Argentinian superstar would attain the 2025 MLS Golden Boot award. The 38-year-old forward has hit the back of the net on 71 occasions through 82 appearances across all competitions since his arrival in South Florida.

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Nashville SC Preview

Capturing this year’s edition of the U.S. Open Cup, B.J. Callaghan’s men have had a successful 2025 campaign. Still, inside the dressing room, they strive to be league champions like the remaining 16 playoff clubs. Regardless of their sixth-place finish in the east, the Boys in Gold matched a club record in points recorded during the regular season, depositing 54 points. 

Chasing Messi in the Golden Boot race, Sam Surridge dazzled on the pitch this term. Cataloging 24 goals in all 34 outings throughout the MLS campaign, the 27-year-old smashed last year's career high of 12 goals. The opposition will need to keep a watchful eye on the lethal striker and limit his ability to create high-dangerous chances, ranking near the top of the leaderboard amongst his peers, Surridge has corralled 108 shots.

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Inter Miami CF vs. Nashville SC - My Pick

Inter Miami CF vs. Nashville SC pick: Inter Miami CF -1 (-137) at BetRivers

This time of the year, MLS scripts get flipped; that said we favour the hosts. The Herons are a club with unfinished business and will want to set the tone with a dominant exhibit on Friday. It will be difficult for Vice City to duplicate what they did to Nashville, but playing on home turf, they have a favourable situation to win by more than a goal. 14 of Miami’s 19 league victories saw them win by more than a one-goal margin.

The home club's firepower could spell bad news for Nashville, which has surrendered 28 goals in 17 road tilts, including 11 conceded in its previous five road matches. The Boys in Gold's back-line play has had its scary moments since August, and with another week gone by, it still might not be enough time to figure out the glitches.

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How to Watch Inter Miami CF vs. Nashville SC

• When: October 24, 8 p.m. ET

• Where: Chase Stadium

• TV: MLS Season Pass, Apple TV