Best Chiefs vs. Colts Prop Bets: Patrick Mahomes Positioned for Huge Game

• The Chiefs are 5-5 with just over a 50% of making the playoffs

• Patrick Mahomes is fourth in passing yards this season

• The Chiefs are a 3.5-point home favorite against the Colts

The Chiefs quest to play in the Super Bowl for the fourth straight season may be coming to an end in 2025. Kansas City is 5-5 with a 52% chance of making the playoffs. 

If Kansas City loses, their playoff chances drop to 35%. Patrick Mahomes will do his best to prevent this from happening against Indianapolis, and he is one of the players on my Sunday prop sheet.

Best Chiefs vs. Colts Prop Bets

This game projects to feature plenty of scoring, setting up a few appealing player props at Fanatics Sportsbook. Claim your Fanatics Sportsbook promo today and get up to $2,000 in FanCash.

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Patrick Mahomes Over 271.5 Passing Yards (-115) at Fanatics Sportsbook

Patrick Mahomes is a multi-time MVP who has remained dominant this season, even if his effort hasn’t always translated into consistent wins. Regardless of record, he’s still the best quarterback in the league.

Andy Reid said after the loss to Denver that the Chiefs needed to run the ball more, but that feels more like coach-speak than a real shift in philosophy. If Kansas City is going to rise or fall this season, it will be on the arm of their franchise quarterback.

That’s why I expect the Chiefs to lean heavily on Mahomes, and his passing prop on Fanatics Sportsbook reflects that. His line is set at 271.5 yards, an undeniably high number.

The Colts rank eighth-worst in the NFL against the pass, allowing 235.3 yards per game, and they score at a high clip, which should force Mahomes to stay aggressive through the air.

Indianapolis also owns the league’s top scoring offense, meaning Mahomes will have to respond with chunk plays and a vertical approach. He’s coming off a 276-yard outing and has cleared this number in three of his past four games, making the over a strong consideration.

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Rahsee Rice Anytime Touchdown (+105) at Fanatics Sportsbook

The Chiefs’ offense has been far more explosive since Rashee Rice returned from suspension, and he’s quickly reestablished himself as their most reliable weapon.

In four games, Rice has totaled 26 catches for 253 yards and three touchdowns, surpassing 80 receiving yards in two of his past three outings.

Although his yardage props are tempting, I’m backing Rice to score a touchdown on Saturday. It’s no coincidence that he hasn’t found the end zone in the past two weeks, and the Chiefs have lost both games.

Rice scored three touchdowns across his first two games back, and Kansas City won both matchups. If the Chiefs are going to get back on track this week, Rice finding the end zone feels like a key part of the formula.

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Daniel Jones Over 16.5 Rushing Yards (-115) at Fanatics Sportsbook

The key to slowing down the Indianapolis Colts is containing Jonathan Taylor, who has 189 carries for 1,139 yards and 15 touchdowns. He leads the league in both rushing yards and rushing scores, making him the focal point of the offense.

The Chiefs’ run defense has been strong in recent weeks, which is why Taylor’s rushing prop sits below 100 yards. His last poor performance lined up with the Colts’ most recent loss, reinforcing how tied their success is to his efficiency.

Since I’m backing the Chiefs, I don’t expect Taylor to dominate on the ground. Still, Indianapolis should be able to generate rushing production through their quarterback, Daniel Jones.

Jones has thrown for 2,659 yards while rushing for 143 yards this season, and he’s coming off a game where he ran seven times for 53 yards.

He’s at his best when he uses his mobility, and between designed runs and the pressure Kansas City’s pass rush creates, Jones has a strong chance to clear his rushing line.

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