CFB Week 2 Parlay: Our Best Bets and Picks for CFB This Weekend

College football returned in full last weekend, and it did not disappoint. Deion Sanders’ Colorado Buffaloes upset the national runner-ups, TCU, while USC QB Caleb Williams put on another strong display as he aims to become the second-ever player to win two Heisman Trophy awards.

It’s still only Week 2, but there are a host of intriguing matchups on the schedule this weekend, including top-25 squads and conference rivals. 

Here are our favorite college football betting picks for the weekend, combined into one parlay.

Following odds taken from FanDuel Sportsbook.

College Football Week 2 Parlay for +410 odds

• Colorado -2.5 vs Nebraska
• Virginia Tech ML vs Purdue
• No. 4 Alabama ML vs No. 11 Texas

Colorado -2.5 vs Nebraska (-115 at FanDuel Sportsbook)

No story grabbed more headlines than the Buffaloes’ 45-42 win on the road over No. 17 TCU, a team that made it to the national championship last season. Coach Prime’s squad was led by his son and quarterback Shedeur Sanders, who threw for 510 yards and four touchdowns in his first P5 matchup. 

Corner/wide receiver Travis Hunter was also excellent, bringing in 11 passes for 119 yards and also coming up with an interception. The Buffs were near-three-touchdown underdogs but won outright after coming up with a huge fourth-down stop late in the game. 

Nebraska, meanwhile, only gained 114 yards through the air with Jeff Sims, who also had three interceptions and only one touchdown. The Cornhuskers’ running game picked up 181 yards and could find success against a weak CU defensive line, but we don’t think they have the offensive potency to hang with what appears to be a high-flying crew.

Nebraska is already 0-1 and only scored 10 points. They held Minnesota to 13, but they’ll be overwhelmed by the UC passing game. Take Colorado to cover—any by a comfortable amount.

Virginia Tech ML vs Purdue (+100 at FanDuel Sportsbook)

The Hokies had a tepid start in their opener against Old Dominion but wound up with a 36-17 win. QB Grant Wells finished with four total touchdowns and linked up with his corps of new transfer receivers on several deep balls, while the defense forced three touchdowns and held the Monarchs to 94 yards through the air.

VT did struggle to generate a push at the point of attack when it was running the ball, but it held up nicely in pass protection. It also looked surprisingly stout on the defensive line despite suspicions it would struggle there.

Purdue, on the other hand, was diced up by Fresno State in a 39-34 loss. They gave up 366 passing yards and four touchdowns to 5-foot-11 sophomore QB Mikey Keene as well as 116 rushing yards to the Bulldogs’ backs. They were effective but not dominant on offense themselves and could not produce stops when they needed.

Tech is still the underdog here, but they’ve got the best entrance and one of the best atmospheres in college football, both of which will help them greatly. They also showed real explosiveness through the air and will walk away with an upset.

No. 4 Alabama vs No. 11 Texas (-275 at FanDuel Sportsbook) 

Alabama has seen its throne atop the college football landscape filled by SEC rival Georgia, but it is still second in odds to win the national championship and a touchdown favorite against the Longhorns. 

The Crimson Tide breezed past Middle Tennessee State 56-7 without ever getting out of first gear. Texas similarly has an easy go of Rice, winning 37-10, but both are in for a real wake-up call when they square off in Tuscaloosa on Saturday.

‘Bama won at Texas last year 20-19 after Quinn Ewers was knocked out of the game with an injury. He will be looking for revenge, but we can’t justify betting against Alabama at home with the amount of talent they have on their roster.

The seven-point spread makes betting on Alabama tricky. The fact those seven points cross all of the critical numbers means that the best bet is just on Alabama to win.