Club Puebla vs. Santos Laguna Prediction: The Sweet Potatoers Look To Break an 11-Game Winless Run

• Dating back to the previous term, Club Puebla hasn’t registered a win since late February

• Santos Laguna conceded four goals against the defending Liga MX champions in last weekend's defeat

On Friday evening, Club Puebla will welcome Santos Laguna to Estadio Cuauhtemoc. The most recent encounter between these two occurred in the 2025 Clausura campaign, which saw Club Puebla secure a 2-0 road win on February 2nd. 

Here, we will break down the betting odds and share our favourite picks for Club Puebla vs. Santos Laguna.

Club Puebla vs. Santos Laguna Betting Odds for Friday, July 25

Diving into the double chance market, the books sense the home club will be the most likely opponent to register a win or draw, priced at -350. For the Guerreros to nab a result they’re listed at -138 while either team winning and avoiding a draw is penned in at -334.

Club Puebla vs. Santos Laguna Odds

The following odds are taken from bet365 Sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose

Club Puebla vs. Santos Laguna Betting Predictions

Club Puebla Preview

Pablo Guede’s men are winless in their two opening contests, kicking off the 2025 Apertura season. Last weekend, the club suffered a 2-1 setback away from home against Mazatlan. Inside the 90-minute frame, Club Puebla outshot their counterpart 11 to seven, but defensive mishaps led to their demise. 

On loan from Club America, Esteban Lozano has looked the sharpest on the pitch in his first two career outings with his new employers. During the Apertura opening weekend, the 22-year-old forward notched his second goal ever in Liga MX. The prized prospect has the potential to carry this club in the future.

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Santos Laguna Preview

The previous week saw Francisco Rodriguez’s troops battle it out against Liga MX’s title holders, Toluca, but after the full-time whistle, the discrepancy between the two was on full display. After coming out hot with an early 2-0 lead, the dream was over for Santos Laguna as soon as Jesus Ocejo was shown a red card after a bad foul. From that moment on, Toluca showed off their top quality, reeling off four straight goals to hand the Guerreros their first loss. 

Early on, Ramiro Sordo has already matched his career high in tallies, as he has found the back of the net in two consecutive appearances, totalling 137 minutes of work. The attacking winger brings a skill set of high pressing and successful ground duels, winning with an average of 60 percent. Look for Sordo to be active upfront, trying to wreak havoc on the opposing back line.

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Club Puebla vs. Santos Laguna - My Pick

• Club Puebla vs. Santos Laguna pick: Santos Laguna double chance (-138) at bet365

Despite the home side prevailing as the favourites in Friday’s tilt, we feel the visitors can give Puebla more than they can handle. Santos Laguna has historically possessed the edge when these two have clashed, dating back to their previous 33 skirmishes; Santos Laguna has only endured five defeats. Going back to the prior 16 fixtures played on Estadio Cuauhtémoc turf, the Green and Whites have cataloged a result in 12 instances. It’s early, but from the looks, Club Puebla could be in for a long Apertura season. After two matches, Laguna has shown they can give teams fits, and if their top performers display their class, this team should be able to claim a draw or win.

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How to Watch Club Puebla vs. Santos Laguna

• When: July 25, 9 p.m. ET

• Where: Estadio Cuauhtémoc

• TV: Univision Networks (Univision, UniMás, TUDN), Fox Sports (FS1, FS2, Fox Deportes), ViX+