Chargers vs 49ers Week 10: 49ers RB Christian McCaffrey Makes Jimmy G’s Offense Scary

• The LA Chargers’ top-9 offense is overshadowed by its 21st-ranked defense

• 49ers' newly acquired RB Christian McCaffrey makes Jimmy G’s offense scary

• Watch Chargers vs 49ers live on Sunday, Nov. 13, 2022, at 8:20 PM ET on NBC

Chargers vs 49ers Week 10 Odds

The odds in the table below are provided by Caesars, BetMGM, and DraftKings. Click on “Bet Here” to head to the sportsbooks and place your bet.

Chargers vs 49ers Week 10 Picks

POINT SPREAD: Los Angeles Chargers +7.0 (-110) at Caesars  

POINTS TOTAL: Under 45.5 (-110) at BetMGM

MONEY LINE: San Francisco 49ers (-300) at DraftKings

POINT SPREAD: Los Angeles Chargers +7.0 (-110) at Caesars

Sports bettors, do not miss the NFL’s Week 10 Sunday Night Football matchup, a cross-conference battle between the underdog Los Angeles Chargers and the San Francisco 49ers, LA with a top-9 offense led by big-armed QB Justin Herbert held back by their 29th ranked run defense that will be challenged by San Fran’s latest pickup, multi-purpose RB Christian McCaffrey.

Forty-Niners’ HC Kyle Shanahan did not waste any time once newly acquired RB McCaffrey stepped into the game plan, the triple-threat playmaker posting a touchdown turkey with a TD pass, TD run, and a TD reception all in Week 8, so now in Week 10 the Chargers defense must split time between the tough trio of CMC, WR Deebo Samuel, and TE George Kittle.

The Chargers have covered the spread in 5 of their last 6 games as road underdogs with a rushing attack featuring RB Austin Ekeler who averages 4.4 yards per carry with almost 100 rushes for 427 yards and 6 TDs plus 60 catches for 381 yards and 4 more TDs, a dual threat LA OC Joe Lombardi features heavily in his game plan using rookie Isaiah Spiller and Sony Michel to relieve him.

POINTS TOTAL: Under 45.5 (-110) at BetMGM

Eight of San Francisco’s last 10 games as favorites have gone under the total points line and that has been the trend for most of the teams this season due to a slow offensive start thanks in part to a shorter preseason, and now the oddsmakers think these two teams will combine for 45.5 points and the bet here is to guess whether the actual total will go over or under.

The Chargers’ offense scores 23 points per game on average whereas the Niners’ offense typically puts 22 points on the board, that total of 45 just under this bet here, while the 49ers defense allows opponents to score 18.4 points per game and LA’s defense allows the teams they play to score 25.8, that total of 44.2 again under the oddsmaker’s prediction.

This game features some defensive start that could make a difference in the final score – the Chargers have LB Khalil Mack (6 sacks) and CB Bryce Callahan (2 INTs) trying to improve the team’s 21st-ranked defense while the 49ers have QB hunting DE Nick Bosa (8.5 sacks) and S Talanoa Hufanga (3 INTs) who should make life difficult for LA QB Herbert and company.

MONEY LINE: San Francisco 49ers (-300) at DraftKings

When it comes to outright wins, the San Francisco 49ers have won six of their last seven games at Levi's Stadium so that hometown bump could affect whether or not you want to bet the money line here with a $300 gamble paying out $100 plus the wager, versus Chargers fans who bet $100 on the money line with a payout of $250 plus the original investment.

Like every other NFL franchise, the Los Angeles Chargers have been dealing with multiple injuries to playmakers like deep threat WR Keenan Allen (hamstring) who is still listed as questionable to play, and now with WR Mike Williams (ankle) out it looks like Joshua Palmer, DeAndre Carter, and Michael Bandy must step up to give QB Justin Herbert trustable targets.

An exciting matchup to watch for is San Fran deep threat WR Deebo Samuel vs Chargers best CB Asante Samuel, a real challenge since Deebo can hurt LA on multiple levels as a pass catcher, a ball carrier, and as a total distraction for the other playmakers on the team, with Los Angeles’ 14th ranked pass defense allowing opponents to throw for over 206 yards per game.

How to Watch Chargers vs 49ers

• What: Los Angeles Chargers vs San Francisco 49ers

• Where: Levi's Stadium in Santa Clara, CA

• When: Sunday, November 13, 2022, at 8:20 PM ET

• How: NBC