Indianapolis Colts vs Tennessee Titans Week 7: Colts Have Won 9 of Their Last 10 Games

• Indy Colts QB Matt Ryan is developing a connection with rookie WR Alec Pierce

• Tennessee Titans are on a 3-game win streak and should be well rested after a bye

• Watch Colts vs Titans live on Sunday, October 23, 2022, at 1:00 PM ET on CBS

Colts vs Titans Week 7 Odds

The odds in the table below are provided by DraftKings, BetMGM, and Caesars.

To explore all the BetMGM features and betting options in more detail, check out our BetMGM Sportsbook review.

Colts vs Titans Week 7 Picks

POINT SPREAD: Tennessee Titans -2.0 (-110) at DraftKings

POINTS TOTAL: Under 42.5 (-110) at BetMGM

MONEY LINE: Tennessee Titans (-145) at Caesars

POINT SPREAD: Tennessee Titans -2.0 (-110) at DraftKings

This is a great AFC divisional matchup between the two top teams of the AFC South as the 3-2-1 Indianapolis Colts travel south to take on the 3-2 Tennessee Titans with the winner possibly taking temporary control of that division depending on tiebreakers, Colts HC Frank Reich versus Titans HC Mike Vrabel.

Keep in mind that this Tennessee team has covered the spread in each of their last four games against the Colts and they have won nine of their last 10 games against AFC South opponents including a Week 4 defeat of the Colts, 24-17, so expect them to keep that string of divisional victories intact given that their star playmaking RB Derrick Henry is healthy now and warming up.

RBs Jonathan Taylor (ankle) and Nyheim Hines (concussion) are listed as questionable and when they don’t play, it puts added pressure on the passing game, with veteran QB Matt Ryan attempting 58 passes in the team’s Week 6 win over the Jaguars which is a lot of wear and tear on Ryan’s 37-year old throwing arm, an unsustainable solution to the run game injury problems.

POINTS TOTAL: Under 42.5 (-110) at BetMGM

These two AFC South teams have not been high scorers so far this season and the oddsmakers are predicting they will produce a total of 42.5 points in Week 7, so this wager has bettors guessing whether it will end up being over or under that, and in the last ten of Indy’s 11 games they have gone UNDER the total points line.

Also, take a look at how these two offenses have been scoring in 2022 – the Colts have averaged 17.2 points per game this year and the Titans have averaged 19.2, that 36.4 total is well under what the oddsmakers are predicting, but when you consider Indy’s defense allows just 20.2 points per game and Tennessee’s D allows 23.6, that 43.8 total is just over this points total.

Always be sure to check for injuries to key players because that could affect the final score of this game, and currently, the Colts have a half dozen players listed as questionable to play including the two RBs and WR Keke Coutee (concussion) while the Titans have four game-time decisions to make including with LBs Zach Cunningham (elbow) and Joe Jones (knee).

MONEY LINE: Tennessee Titans (-145) at Caesars

After the Colts' offense line allowed QB Matt Ryan to get sacked six times in Week 5, they kept him vertical the entire game in Week 6, so expect them to try and do the same again against this Titans front line that has a total of 13 team sacks so far this season, the key to longevity for ‘Old Man’ Ryan being to keep from being hit in a league that now loves protecting its QBs.

Titans QB Ryan Tannehill’s offense ranked second worst in the NFL now so to beat this Colts team that must change, their 21st rushing attack starring RB Henry who has just generated two games in a row with 100+ rushing yards and 3 total TDs, their 28th passing attack the real source of struggle with a big game needed from WRs Robert Woods and Cody Hollister.

For this money line bet, place $145 on the Tennessee Titans to win outright here and you can win back your wager plus $100, or else if the Indianapolis Colts look stronger at this point then bet $100 on them and win $122 plus your original investment, either way, a great chance to get involved in the action as the AFC South’s best two football franchises face off in Week 7.

How to Watch Colts vs Titans

• What: Indianapolis Colts vs Tennessee Titans
• Where: Nissan Stadium in Nashville, TN
• When: Sunday, October 23, 2022, at 1:00 PM ET
• How: CBS