Monday Night Football Picks Week 17: The Lions Head West Looking to Secure the NFC’s Top Seed

• The Lions lead the league with 32.9 points per game this season

• Niners LB Dre Greenlaw is expected to miss the final two games of the season

• RB Isaac Guerendo is averaging 5.2 YPC

The San Francisco 49ers will welcome a Detroit Lions team to town eager to secure the NFC’s top playoff spot. The Niners’ playoff hopes are over as the injuries pile up, but their talent makes them a dangerous opponent to overlook.

We have you covered if you want to wager on this week’s Monday Night Football matchup between the 49ers and Lions. Below, we’ll share our favorite bets for this matchup, helping you win your wagers on Monday night. We’ll use odds from Caesars Sportsbook, which gives new users a Bet $1, Double Your Winnings Your Next 10 Bets offer when they sign up using promo code WSNDYW.

Lions -3.5 (+100) at Caesars Sportsbook

The Niners have been broken over the last few weeks. They lost their top two running backs for the season and suspended linebacker De’Vondre Campbell for refusing to play. San Francisco has lost five of their previous six games as a result, with two of their ugliest coming over the last couple of weeks.

The Lions' offense leads the league in points per game (32.9) and has scored 34+ in three straight games. The Niners’ defense has Bosa healthy, but now linebacker Dre Greenlaw will likely miss the season's final two weeks. That is a significant problem, considering his backup is the suspended Campbell. 

Linebacker Dee Winters is injured and questionable about playing on Sunday. That would leave the team with three linebackers on the active roster. Add in that starting safety Ji’Ayir Brown is also dealing with an injury, and you can see why we expect the Lions to score with ease on Monday Night.

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Over 50.5 (-110) at Caesars Sportsbook

We have talked a lot about how injured the Niners' defense is, but the Lions have been hit harder than anyone. While they have several key pieces back in the lineup, they are still without their superstar, Aidan Hutchinson. 

This bet is being made assuming that running back Isaac Guerendo will play this week. The third-string back was impressive after being thrust into the starting role, averaging an impressive 5.2 YPC on the season. The Lions have a great run defense but can be beaten through the air. Guerendo is good enough to keep the run defense honest, preventing Detroit from loading up against the pass.

The Niners won’t score much, but the Lions will make up for that to surpass this total.

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49ers Under 23.5 Points (-115) at Caesars Sportsbook

The Lions' defense has some holes, but they are better than the Rams and Dolphins. Both teams shut the Niners' offense down, holding them to less than 18 points. Scoring has become a premium for this unit lately, averaging 16.3 points per game. 

Don’t expect this San Francisco offense to turn things around now that their playoff hopes are officially over.

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