Monday Night Football Week 5 Picks: Can Mahomes Shine Without Brown and Rice?

• Rashee Rice and Hollywood Brown will both bet out on Monday

• Xavier Worthy had 73 yards and a touchdown in Week 4

• Alvin Kamara has the second-most carries in the league this season

Monday Night Football brings us one of the weekend's most intriguing matchups. On one side are the New Orleans Saints, who are looking to bounce back after two tough losses. On the other side is a Chiefs squad without its top two receivers and running back.

If you want to wager on this week’s edition of Monday Night Football, we are here to help. Below, we’ll share our favorite betting picks for this fantastic matchup, helping you win your wagers on Monday night. We’ll use odds from Caesars Sportsbook, which gives new users a $1,000 First Bet Offer OR $250 in Bonus Bets when they sign up using promo code WSN1000.

Saints +5.5 (-110) at Caesars Sportsbook

While the Chiefs enter this game 4-0 and will be at home, we expect the Saints to challenge them throughout the game. That is primarily due to Kansas City’s growing injury report, which includes Hollywood Brown, Rashee Rice, and Isiah Pacheco. That once again leaves Mahomes with an awful receiving corps, a scenario we saw him struggle with last season.

In addition to the injuries, Travis Kelce is also struggling to get open. That will be more difficult with the team’s top two receivers. The Saints have struggled to stop the pass this season, but the broken Chiefs’ attack won’t present much of a challenge.

The Saints' offense has been better than expected through four weeks, ranking ninth in yards gained and first in points per game. The Chiefs' defense has not been the dominant force it has been in the past, so expect New Orleans to put up some points on Sunday.

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Xavier Worthy Anytime TD Scorer (+170) at Caesars Sportsbook

With Rice and Brown both out, rookie Xavier Worthy will take on a much more significant role in the Chiefs’ offense. We saw that last week when he connected with Mahomes for 73 yards and a touchdown. The speedster is incredibly difficult to cover and will be the biggest threat to a shakey Saints’ pass defense.

In addition to his talent as a receiver, the team has also been using him on the ground. While he doesn’t get many carries, that will change this week. The New Orleans run defense is fantastic and will stifle Kareem Hunt. That will lead Kansas City to use Worthy’s speed to work around the fearsome front seven.

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Alvin Kamara Over 54.5 (-115) at Caesars Sportsbook

The Chiefs' run defense has been one of the league’s best for the last few seasons, but they will have their hands full with Alven Kamara on Sunday. The veteran back has the fourth most rushing yards in the league (362) and leads in touchdowns (5). He is averaging an impressive 4.5 YPC and has gone for at least 77 rushing yards in all four Saints’ games this season.

Even if Kamara can’t replicate his impressive season numbers this weekend, his usage total alone will get him about this total. The 29-year-old has gotten the second-most carries in the league through four weeks, showing that the Saints’ offense is focused on moving the ball on the ground this season.

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