Clemson vs. Pitt Picks, Predictions and Odds: Loser OUT of ACC Championship Contention

• Pitt lost back-to-back games to ACC opponents

• Clemson’s great running game as of late is facing a top 10 run defense

• Pitt’s starting QB is questionable with a head injury

The No. 20 Clemson Tigers are headed north to face the Pittsburgh Panthers in a battle between two 7-2 ACC teams looking to stay alive for a spot in the conference championship game.

One of Clemson’s two losses came against Georgia, meaning they are 6-1 and second to only SMU in the ACC. Pitt was in control of its future but lost back-to-back games to SMU and Virginia and now sits in fifth in the conference ladder.

Here, we will analyze the impending matchup with substantial implications and share our favorite Clemson vs. Pitt betting picks.

Clemson vs. Pitt Odds

Odds for the Clemson vs. Pitt Saturday's matchup are courtesy of FanDuel Sportsbook. Place your bets on this matchup and claim $150 in bonus bets at FanDuel.

Clemson vs. Pitt Predictions 

Clemson is coming off a 24-14 win over Virginia Tech its last time out. While the scoreless first half was a masterclass in offensive ineptitude from both sides, QB Cade Klubnik finished with 211 yards, three touchdowns, and a pick, while the team ran 46 times for 167 yards.

The Tigers’ two losses were in Week 1 to Georgia and a couple of weekends ago to a sneakily-solid Louisville squad. Klubnik has 28 total touchdowns and four touchdowns for the season, while running back Phil Mafah ran for 109 yards per game and 6.1 yards per carry.

Whereas Dabo Swinney usually has solid defenses, this team is only 32nd in defensive EPA per play. They really struggle to contain the run, ranking 75th in yards allowed per carry (4.4).

Pitt had a great start to the year, although its best win was against Syracuse. The loss to SMU, a 48-25 thumping, was somewhat expected, though last weekend’s home defeat to UVA came out of left field. 

Fans of the Panthers will blame the UVA result on the loss of QB Eli Holstein (questionable for Saturday) to a head injury. But up until that point, he was only 10/23 for 121 yards. That’s a far cry from his season standard of 241.6 yards per game, 20 total TDs, and six INTs.

Pitt allows 26.1 points per game (70th) but ranks 10th in the country in yards allowed per rush attempt (3.0). They also have a high mark of 24 in EPA per rush play compared to 48th per dropback attempt.

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Clemson vs. Pitt: My Pick

• My Pick: Clemson to cover the spread at -10.5 (+100) at FanDuel

There are serious questions relating to the health of Holstein. It’s also notable that Pitt looked like a totally different team when it faced a strong team and in the week immediately following that.

Clemson is balanced and should be able to move the ball against a Pitt defense that provided little to no resistance against SMU. The potential for a backdoor cover is there, but we don’t think it’ll happen.

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How to Watch Clemson vs. Pitt

• When: Saturday, Nov. 16 @ 12:00 p.m. ET

• Where: Acrisure Stadium, Pittsburgh, PA

• Watch: ESPN

Clemson vs. Pitt Best Promos and Sportsbooks

All of the major college football betting sites have Clemson favored by 10 or 10.5 points at the time of writing. 

Clemson bettors will find the Tigers priced at -10 (-110) at several sites, including bet365, BetMGM, Caesars, and ESPN Bet.

Pitt bettors will find the best odds at FanDuel, where they are +10.5 (-122).

Anyone who bets on Clemson vs. Pitt at FanDuel sportsbook can win $150 in bonus bets with a winning $5 wager.

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Clemson vs. Pitt Injuries

Clemson Injuries

• Tyler Brown (WR) - Doubtful (ankle)

• Collin Sadler (OL) - Out (foot)

• Peter Woods (DL) - Questionable 

• Shelton Lewis (CB) - Questionable

• DeMonte Capehart (DL) - Questionable

• Quinn Castner (K/P) - Out (leg)

Pitt Injuries

• Eli Holstein (QB) - Questionable (head)

• Konata Mumpfield (WR) - Questionable

• Branson Tylor (OL) - Out (knee)