49ers vs Cardinals: Cardinals QB Kyler Murray Still Listed as Questionable to Play

• 49ers HC Kyle Shanahan has worked new RB Christian McCaffrey into the offense

• Arizona Cardinals QB Kyler Murray (hamstring) is still listed as questionable to play

• Watch 49ers vs Cardinals live on Monday, Nov. 21, 2022, at 8:15 PM ET on ESPN

49ers vs Cardinals Week 11 Odds

 49ers vs Cardinals Week 11 Picks

POINT SPREAD: Arizona Cardinals +8.0 (-110) at BetRivers

POINTS TOTAL: Under 43.5 (-110) at DraftKings

MONEY LINE: San Francisco 49ers (-365) at Caesars  

POINT SPREAD: Arizona Cardinals +8.0 (-110) at BetRivers

The final game of the NFL’s Week 11 is an MNF matchup in the Estadio Azteca in Mexico City between the San Francisco 49ers and the Arizona Cardinals, this NFC West battle is a part of the NFL’s International program meant to spread the glory of pro football worldwide, this game a hot ticket with divisional implications and plenty of household names facing off.

Arizona has covered the spread in seven of their last eight games as underdogs against San Francisco and with this many points gifted by the oddsmakers (+8.0), we think they will make it eight out of nine, with QB Kyler Murray (hamstring) still listed as questionable to play and his backup Colt McCoy ready to step in again the way he did for a win in Week 10 versus the Rams.

Look at the talent that the 49ers now have including WRs Deebo Samuel, Brandon Aiyuk, and pass-catching TE George Kittle plus now OCs Chris Foerster and Bobby Slowik have triple-threat RB Christian McCaffrey to game plan with, a multi-tooled player who can throw, catch, and run with the football with great effectiveness, all facing the Cardinals’ 23rd ranked defense.

POINTS TOTAL: Over 43.5 (-110) at DraftKings

Each of Arizona’s last four games have gone over the total points line and that makes sense when you consider their offense scores 23 points per game on average, and add that to what the 49ers’ offense generates each week, 22 points per game and that total of 45 points is just over what the oddsmakers are predicting, our choice for this Week 11 points total bet.

If that is not enough to sway you towards the over in this bet, take a look at how effective both these defenses tend to be, with the Niners’ defense allowing opponents to score an average of 18.1 points per game and the Cardinals’ defense allowing 25.8 points per game, that total of 43.9 still slightly over what this bet allows (43.5) so chances are that could be how this game ends up.

The Arizona weather should not factor in here, but injuries always do, so be sure to check out both injury reports before you place a bet, with the San Francisco 49ers listing three players as questionable including DE Arik Armstead (foot) while the Arizona Cardinals have a half dozen coach’s decisions including C Max Garcia (shoulder) and LT DJ Humphries (back), with TE Zach Ertz (knee) now officially out.

MONEY LINE: San Francisco 49ers (-365) at Caesars

Sometimes a sports bettor just knows their team will win and for those instincts, there is always the money line bet where you can wager on one team winning outright, and given that San Francisco has won four of its last five games against NFC West opponents plus the level of talent on that roster, we like the 49ers for this money line bet even though it’s a costly one.

For anyone new to sports betting, the way the money line bet breaks down here is for a $365 bet on San Francisco to win it would pay out $100 plus the initial investment whereas a $100 money line bet on the Arizona Cardinals to outscore the Niners with no oddsmaker help would pay a winner $285 plus that original wager amount, a fine payday either way for true believers.

This game is being played in Mexico City so it will involve some extra travel and an adjustment period to the new surroundings so that could effect how these players produce on Monday night but given the implications of this divisional matchup in terms of affecting the odds of a postseason, expect HCs Kyle Shanahan and Kliff Kingsbury to bring their A game plans.

How to Watch 49ers vs Cardinals

• What: San Francisco 49ers vs Arizona Cardinals

• Where: Estadio Azteca in Mexico City

• When: Monday, November 21, 2022, at 8:15 PM ET

• How: ESPN