49ers vs. Packers Picks, Predictions & Player Props: Nick Bosa Still Questionable

• Nick Bosa has a 50/50 chance to play this weekend thanks to a hip injury

• Brock Purdy is averaging 5.2 YPC on the ground this season

• Jaire Alexander is questionable to play 

The Green Bay Packers will be hosting the rival San Francisco 49ers this weekend. These teams met in a thrilling postseason matchup last season, with the Niners mounting a second-half comeback to win the game. Will history repeat itself on the Frozen Tundra this weekend?

49ers vs. Packers Odds

Below are the odds for the 49ers vs. Packers game from Caesars Sportsbook. Sign up with Caesars using our promo code WSN1000 and get a $1,000 First Bet Offer OR $250 in Bonus Bets.

49ers vs. Packers Predictions

This pick comes down to one player: Nick Bosa. The standout defensive end has been leading this defense but is dealing with a hip injury that has the team giving him a 50/50 chance to play on Sunday. 

The Niners lost their matchup against the Seahawks primarily because of Bosa’s injury. Seattle’s offense was far better while the pass rusher was on the sidelines, allowing them to steal a win on the road. Hip injuries linger for a long time, and we think it will lead the Niners to limit Bosa even if he does suit up on Sunday. 

We believe the Packers are about to catch fire and finish the season for the second year. They survived a dangerous game in Chicago last week, beating a Bears team desperate to save its season and break a ten-game losing streak against their archrival. The team didn’t have their best stuff but still survived.

When reviewing their schedule, Green Bay’s last two losses came when Jordan Love was injured. The quarterback’s MCL was clearly hurting in both games, leading to the quarterback being unable to put much weight on it and making bad passes. 

The Packers’ quarterback seems to be feeling better, and the result will be an offensive explosion that begins on Sunday.

49ers vs. Packers - My Pick

• My Pick: Packers -2 (-110) at Caesars Sportsbook

If both teams were healthy, we would take the Niners in this one. However, with their growing injury list and playing on the road, we are confidently rolling with the Pack on Sunday.

Claim $1,000 First Bet on Caesars

49ers vs. Packers Best Prop Bets

Jordan Love Over 251.5 Passing Yards (-117) at Caesars Sportsbook

With Bosa’s injury, Jordan Love will have a lot of time to work on Sunday. The quarterback has one of the deepest receiving corps in the country, which will challenge a banged-up Niners defense. Love and the Packers have struggled in the red zone this season, but they have been effective in getting it there. That’s why we are taking the over and yards instead of touchdowns.

Use code WSN1000 for $1,000 First Bet on Caesars

Brock Purdy Over 21.5 Rushing Yards (-117) at Caesars Sportsbook

Brock Purdy has been incredibly effective running the football this season. He has 267 yards and four touchdowns, averaging an impressive 5.2 YPC average. He has surpassed this total in three of his last four games, and we are certain he will do so again on Sunday.

We saw the Packers get torched by Caleb Willams for 70 rushing yards on nine carries last week. Williams is the better ball carrier, but the Packers' defense showed it could not contain him in the pocket, even against the Bears' subpar offensive line.

Bet at Caesars and Get $1,000 First Bet

Deebo Samuel Over 48.5 Receiving Yards() at Caesars Sportsbook

Packers’ cornerback Jaire Alexander has had the upper hand against Deebo Samuel in the last few matchups between the stars. However, the corner is questionable, and he seems likely to miss the game. 

The Packers do not have enough depth at cornerback to replace Alexander's talent. This will allow Deebo to rack up some yards, likely motivated by his past failures against the Pack. 

Join Caesars Today and Get $1,000 First Bet

49ers vs. Packers Best Promos and Sportsbooks

Check out the best NFL promos and NFL betting sites available in the U.S. for Sunday's matchup between the 49ers and Packers. We have listed some of our top favorites in the table below.

*Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms.

How to Watch 49ers vs. Packers

• When: Sunday, November 24 at 1:00 PM EST

• Where: Lucas Oil Stadium in Indianapolis, IN

• Where to Watch: FOX, NFL Sunday Ticket

49ers vs. Packers Injuries

San Francisco 49ers Injuries

• George Kittle TE - Questionable

• Brock Purdy QB - Questionable

• Tatum Bethune LB - Doubtful

• Kevin Givens DT - Questionable

• Trent Williams OT - Questionable

• Nick Bosa DE - Questionable

Green Bay Packers Injuries

• MarShawn Lloyd RB - NFI-R

• Jaire Alexander CB - Questionable

• Colby Wooden DT - Questionable

• Jordan Morgan OT - IR

• Luke Musgrave TE - IR

More NFL Week 12 Picks and Bets

Sunday Night Football Week 12 Picks

Sunday Night Football Week 12 Prop Bets

Sunday Night Football Week 12 Same Game Parlay

Best Christian McCaffrey Prop Bets in NFL Week 12