Lions vs. Bills Picks, Predictions & Player Props: The League’s Top Teams Face Off

• The Lions have 12 defensive players on IR and five listed as questionable

• Rasul Douglas and Taylor Rapp are both questionable to play

• The Bills have scored 30+ points in seven straight games

A potential preview of Super Bowl LIX highlights Week 15’s slate of games. The Buffalo Bills will look to bounce back as they head to the Motor City to take on the Detroit Lions. Both teams are dealing with significant injuries to their defense, setting us up for a thrilling Sunday afternoon showdown.

Lions vs. Bills Odds

Below are the odds for the Lions vs. Bills game from Caesars Sportsbook. Sign up with Caesars using our promo code WSNDYW and get a Bet $1, Double Your for Winnings Your Next 10 Bets offer.

Lions vs. Bills Predictions

This matchup is set up for some big fireworks on Sunday.

The Bills will enter this game with their secondary potentially missing two crucial pieces. Rasul Douglas and Taylor Rapp are dealing with injuries, which is a significant problem when facing an offense like the Lions. The unit allowed the Rams to score 44 points last week, and we don’t expect that to improve with Douglas and Rapp injured.

The Lions' offense has been on fire this season, leading the league in points while ranking second in yards (243.8) per game. Their best work has come at home, averaging 35 over seven games. With the Bills’ defense injured and coming off a 44-point effort, expect the Lions to stay hot at home on Sunday.

The Lions’ defense is one of the best in the league, but injuries continue to plague the team. The unit has 12 players on IR, with another five questionable to play in this game. Even the best defenses have struggled to slow Josh Allen and the Bills down this season, and a banged-up Lions unit won’t be able to get the job down tonight. 

Given that the game will be played indoors at Ford Field, we have all the ingredients for a Sunday shootout.

Lions vs. Bills My Pick

• My Pick: Over 54.5 (-110) at Caesars Sportsbook

This is a high total, but one of these teams may surpass it alone. With these two explosive offenses teeing up against banged-up defenses indoors, this bet will be covered early on Sunday.

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Lions vs. Bills Best Prop Bets

Amon-Ra St. Brown Anytime TD (+123) at Caesars Sportsbook

Amon Ra St. Brown is coming off a quiet game, but he is set up to break out tonight. As of the time of this writing, safety Taylor Rapp and corner Rasul Douglas are unable to practice due to injuries. If they can’t go or are limited, it will have a massive impact on this Bills pass defense, opening up room for the Lions’ star receiver.

While St. Brown hasn’t scored in three consecutive games, he has done so in eight straight games. Sunday will allow him to start another streak heading into the playoffs.

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Lions TD on Opening Drive (+195) at Caesars Sportsbook

Injuries to the Bills’ secondary will take a toll and open things up for a dangerous Lions offense. They opened last week with a touchdown against a good Packers defense, while the Bills’ defense allowed one. We expect history to repeat itself on Sunday.

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Buffalo Team Points Over 26.5 Points (-120) at Caesars Sportsbook

This is one of the easiest bets of the NFL weekend. The team has surpassed this total in seven consecutive games, scoring 30+ in each. That is primarily due to Josh Allen's play, which was coming off a game where he had three passing and three rushing touchdowns.

Allen’s play has made up for James Cook’s inconsistent play and the team’s mediocre receiving corps. He can do so again tonight against a badly injured Lions’ defense.

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How to Watch Lions vs. Bills

• When: Sunday, December 15 at 4:25 PM EST

• Where: Ford Field in Detroit, MI

• Where to Watch: CBS, NFL Sunday Ticket

Lions vs. Bills Best Promos and Sportsbooks

Check out the best NFL promos and NFL betting sites available in the U.S. for Sunday's matchup between the Lions vs. Bills. We have listed some of our top favorites in the table below.

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Lions vs. Bills Injuries

Lions Injuries

• DJ Reader DT - QUESTIONABLE

• Josh Paschal DE - QUESTIONABLE

• Levi Onwuzurike DE - QUESTIONABLE

• Taylor Decker OT - QUESTIONABLE

• Aidan Hutchinson DE - IR

Bills Injuries

• Baylon Spector LB - IR-R

• Dawuane Smoot DE - IR-R

• Taylor Rapp S - QUESTIONABLE

• Rasul Douglas CB - QUESTIONABLE

• Casey Toohill DE - QUESTIONABLE

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