Monday Night Football Week 3 Picks: Jaguars Visit Buffalo Hungry for a Win

• The Bills held Tyreek Hill and Jaylen Waddle to 65 yards in Week 2

• Khalil Shakir leads the team in receptions, targets, yards, and touchdowns

• James Cook scored three touchdowns against Miami last week

The Jaguars have played two close games to begin the 2024 season but are still searching for their first win. Things won't be any easier on Monday when they visit the 2-0 Buffalo Bills, but there are a lot of great bets on the board.

If you want to wager on this Monday Night Football clash, you have come to the right place. Below, we’ll share our favorite betting picks for this fantastic matchup, helping you win your wagers on Monday night. We’ll use odds from Caesars Sportsbook, which gives new users a $1,000 First Bet Offer when they sign up using promo code WSN1000.

Bills -5.0 (-110) at Caesars Sportsbook

The Bills have been among the most impressive teams over the season's first two weeks. They beat a Cardinals team far better than expected before blowing out the Dolphins on the road. They have been battle-tested and thrived, even with several key players departing in the offseason.

We are willing to give up these points because of the Bills’ secondary. They completely shut down Marvin Harrison Jr. in Week 1 and held Tyreek Hill and Jaylen Waddle to 65 combined yards in Week 2.

The Jags offense hasn’t looked good, but rookie receiver Brian Thomas Jr. has looked dangerous over the first two weeks, posting 141 yards and a touchdown. However, quarterback Trevor Lawrence is only completing 51% of his passes, limiting Thomas’s production. That won’t change tonight on the road against an outstanding Bills pass defense.

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Khalil Shakir Over 43.5 Receiving Yards (-115) at Caesars Sportsbook

Khalil Shakir was a fifth-round draft pick in 2022 and now is the team’s top receiving option. He is still adjusting to the role but leads the team in receptions, targets, yards, and touchdowns. It feels like the 24-year-old is about to go off, and he will have a great chance to do that on Monday Night Football.

The Jags have allowed the third most passing yards in the league this season. They have allowed five receivers to surpass the 43-yard mark in their first two games. That number will go up in Buffalo tonight, with Shakir leading the way.

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James Cook TD Scorer (-110) at Caesars Sportsbook

With Stefon Diggs gone, James Cook has become the team’s top playmaker not named Josh Allen. He has dominated over the first two weeks, rushing for 149 yards and two touchdowns while averaging 5.0 YPC. The running back has also been active in the passing games, with 49 yards and a touchdown scored through the air.

The Bills don’t have many weapons when they are in the red zone, lacking a star receiver or tight end. That has led to them largely relying on Cook, whose ability to run and catch makes him incredibly dangerous.

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