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2nd Overall Pick NFL Draft Predictions & Odds 2021

Written by: Mike Lukas
Updated October 14, 2022
11 min read
Second Overall Pick
  • The NFL has their eyes on QB Zach Wilson, the 6’ 3” 210-pound playmaker from BYU
  • Depending on trade-ups and needs, OT Panei Sewell could steal this 2nd pick honor
  • In the top five possible 2nd overall draft picks, there are 3 QBs, an OT, and a WR

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2nd Overall Pick Odds

Odds taken 27 April 2021 from DraftKings Sportsbook

Player/University Odds
Zach Wilson, BYU QB -10000
Justin Fields, Ohio State University QB +1600
Trey Lance, North Dakota State QB +3300
Panei Sewell, University of Oregon OT +6600
Ja’Marr Chase, LSU WR +10000
Kwity Paye, Michigan DE +50000

Odds from DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or check out more offers and promo codes for the best online sportsbooks.

Second Overall Pick Predictions and Picks

Tough to bet against the favorite here, Wilson with 33 TD passes in twelve games last season but expect Fields to get some looks at this 2nd spot, too.


Zach Wilson (-10000)

How to Watch NFL Draft 2021/2022

NFL Draft Information
What NFL Draft 2021/2022
Where Cleveland, Ohio
When Thu, April 29 thru Sat May 1, 2021
How to watch NFL Network / ESPN

Favorites to Win

Zach Wilson, BYU QB

This twenty-one-year-old playmaker threw for 7,652 total yards and 56 touchdowns and had only 15 interceptions in his three seasons at BYU, showing his accuracy by completing 67.6 percent of his passes.

Wilson has had his share of big-game experience, taking his Cougars to three bowl games (Famous Idaho Potato in 2018, Hawaii in 2019, and Boca Raton in 2020) and was named offensive MVP of the Boca Raton Bowl after completing 26-of-34 passes for 425 yards and 3 TDs.

Many mock drafts have Wilson going to the New York Jets with the second overall pick, a pro team whose current starting QB, Sam Darnold, was also a first-round selection in 2018.

Justin Fields, Ohio State University QB

It is difficult to imagine this Heisman Trophy finalist and 2x first-team All-Big Ten player not going to one of the top four teams, but whether he aces out Wilson for the second spot remains to be seen.

Fields showed great field leadership and range of motion as he led his Buckeyes to an appearance in the 2021 College Football Championship, but they could not keep up with Alabama and fell big, 24-52, and despite his career completion percentage of 68 and a passer rating of 178.8, that loss could bump Fields down this list.

Plenty of mock drafts have Fields going to the Atlanta Falcons with the fourth overall pick, but there are some which predict him lasting until eighth overall, where the Panthers could happily snag him.

Panei Sewell, University of Oregon OT

One of the more valuable positions in the NFL these days is an offensive tackle, and Oregon’s Panei Sewell is regarded as one of the top prospects of this draft and is predicted to go in the top three.

So much to love about this 6’ 6” 325-pound offensive tackle who was born in Malaeimi, a small town in American Samoa, and the fact that he opted out of the 2020 season due to the COVID-19 pandemic makes him a well-rested and healthy pro prospect.

Some mock drafts have Sewell going third to either the Dolphins, who could definitely use some O-line help, or else the Bengals if they decide to trade up with Miami, who could use more protection for their star quarterback Joe Burrow.

No Chance to Win

Ja’Marr Chase, LSU WR

Yet another player in this 2021 draft who opted out of the 2020 season due to the COVID-19 pandemic, Chase was last seen on the field during the 2019/20 National Championship game where he posted a record 221 receiving yards against Clemson.

During the 2019 season, Chase recorded 84 total receptions for 1,780 yards and 20 touchdowns, numbers that should translate to the pro level, his draft spot truly depending on the needs of the top selecting teams.

Some mock drafts have Chase going in the fifth round to Miami with a trade-up from Cincinnati.

Kwity Paye, Michigan DE

If you are looking for a uniquely American story, Paye is your guy, a 22-year old Rhode Islander who was born in a refugee camp in Guinea during the First Liberian Civil War and immigrated to the U.S. with his family when he was only six months old.

With four college seasons and 59 games under his belt, Paye has recorded 11.5 total sacks, a forced fumble, a pass defended, and 97 total tackles with 23.5 of those being for a loss.

Paye is a total longshot here, with the most generous mock drafts projecting him to go to the Vikings with the 14th overall pick.

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Mike Lukas

1205 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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