NFL Week 13 Odds: Odds and Betting Lines for Every Game

• The Patriots and Rams hold the top seeds in their respective leads

• There are no teams on a bye in Week 13

• There are three games on Thanksgiving and one on Black Friday

The Patriots and Rams are the frontrunners in the AFC and NFC, respectively. Week 13 is critical on the schedule because no teams are on a bye, so there should be plenty of movement in the standings. 

For more info on the league standings, check our latest NFC Championship odds, along with AFC Championship odds.

The week starts on Thursday with three Thanksgiving games. Once the slate begins, we should be treated to plenty of competitive matchups. 

Here, we will provide a brief analysis of each matchup in Week 13 and discuss the corresponding odds.

NFL Odds for Week 13

Odds courtesy of bet365 sportsbook. bet365 is ranked as one of our top recommended NFL betting sites. If you bet $5, you get $150 in bonus bets by using our bet365 bonus code WSN365 at registration.

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Packers vs. Lions Odds, Thursday, 1:00 PM EST

• Packers: Spread +2.5 (-110) | Moneyline +125

• Lions: Spread -2.5 (-110) | Moneyline -150

• Total: Over/Under 49.0 (-110/-110)

This NFC North rivalry reignites on Thanksgiving as the Lions host the Packers at Ford Field. The Packers claimed the Week 1 meeting, and they dominated Detroit in the process. 

The Lions enter with momentum after beating the Giants in overtime. Jahmyr Gibbs was fantastic in the matchup, and he is positioned for another big performance against the Packers.  

Green Bay’s defense has been solid, but the Packers are set up to fail in this spot. Look for the Lions to get revenge after losing to Green Bay to open the year. 

Check out the latest NFC North odds and standings here.

Chiefs vs. Cowboys Odds, Thursday, 4:30 PM EST

• Chiefs: Spread +3.5 (-115) | Moneyline -180

• Cowboys: Spread -3.5 (-105) | Moneyline +150

• Total: Over/Under 52.0 (-110/-110)

Thursday’s mid-afternoon Thanksgiving matchup features two high-profile teams looking to surge. The Chiefs and Cowboys are both coming off dramatic wins.

Each team overcame a double-digit fourth-quarter deficit to win its respective matchup. Dak Prescott and CeeDee Lamb have been excellent, but the Chiefs are fighting for their playoff lives. 

You never bet against Patrick Mahomes with his season on the line. This was clear against Denver in Week 12. 

Bengals vs. Ravens Odds, Thursday, 8:20 PM EST

• Bengals: Spread +6.5 (-105) | Moneyline +260

• Ravens: Spread -6.5 (-115) | Moneyline -320

• Total: Over/Under 51.5 (-110/-110)

In a key AFC North clash on Thanksgiving night, the Ravens host the Bengals. Baltimore has rallied from a slow start and should continue leaning on star running back Derrick Henry and quarterback Lamar Jackson. 

For Cincinnati, they may get Joe Burrow back in the lineup, which should make a difference. However, the Bengals' defense has been terrible all season. 

While they stepped up against the Patriots last week, it will be challenging to contain Jackson and Henry, who tend to pop against divisional opponents.

Check out the latest AFC North odds and standings here.

Bears vs. Eagles Odds, Friday, 3:00 PM EST

• Bears: Spread +7.0 (-115) | Moneyline +225

• Eagles: Spread -7.0 (-105) | Moneyline -315

• Total: Over/Under 44.5 (-110/-110)

The Eagles blew a 21-point lead to the Cowboys last week, so they should be ready to explode in Week 13. Philadelphia, led by quarterback Jalen Hurts and receiver A.J. Brown, will look to show why they’re the defending Super Bowl champions. 

Follow our link to see the latest Super Bowl odds and predictions.

Chicago has been better than expected this season, leading the NFC North. Caleb Williams has looked better, and the team is playing great in close games. 

While Chicago can compete, this is a terrible spot for the Bears against the defending champions. 

49ers vs. Browns Odds, Sunday, 1:00 PM EST

• 49ers: Spread -6.0 (-110) | Moneyline -270

• Browns: Spread +6.0 (-110) | Moneyline +220

• Total: Over/Under 39.5 (-110/-110)

The 49ers beat up the Panthers in Week 12, and they’re playing very well. The 49ers bring their usual mix of star power, including Brock Purdy and Christian McCaffrey, to Cleveland for this contest.

Shedeur Sanders will make his second start, and he became the first Browns’ rookie quarterback since 1995 to win their initial start. 

This game could be close because of the Browns' defense, but San Francisco has more talent across the board. 

Jaguars vs. Titans Odds, Sunday, 1:00 PM EST

• Jaguars: Spread -6.5 (-110) | Moneyline -340

• Titans: Spread +6.5 (-110) | Moneyline +270

• Total: Over/Under 41.5 (-110/-110)

The Jaguars and Titans know each other too well for this to be anything but a dogfight. Trevor Lawrence has been playing well, and Jacksonville’s defense has a knack for making timely plays. 

Tennessee depends heavily on its run game and physicality, especially at home with its rookie quarterback. 

These divisional matchups usually come down to which team controls the line of scrimmage, and the Jaguars have the slight edge.

Texans vs. Colts Odds, Sunday, 1:00 PM EST

• Texans: Spread +4.5 (-110) | Moneyline +185

• Colts: Spread -4.5 (-110) | Moneyline -225

• Total: Over/Under 44.0 (-110/-110)

The Texans and Colts always seem to play close games, and this feels like another one. 

Indianapolis was beaten on a last-second field goal by the Chiefs in Week 12. They won’t have an easy time picking up a win because Houston is electric on defense. 

Houston wants C.J. Stroud back in rhythm because when he’s on, this offense is hard to stop. Stroud has been hurt, but he should return for this game. 

Indianapolis leans on Jonathan Taylor, but the Texans should have an answer. 

Saints vs. Dolphins Odds, Sunday, 1:00 PM EST

• Saints: Spread +6.0 (-110) | Moneyline +220

• Dolphins: Spread -6.0 (-110) | Moneyline -270

• Total: Over/Under 41.5 (-110/-110)

The Dolphins have a chance to score a lot on the Saints. Tua Tagovailoa and Jaylen Waddle turn every play into a track meet. 

New Orleans has been up and down, but the team still has enough talent to keep games competitive. 

Miami continues to play hard, but it’s tough to beat the Saints at this time of the year. The Dolphins' inconsistencies are a concern in this spot. 

Falcons vs. Jets Odds, Sunday, 1:00 PM EST

• Falcons: Spread -2.5 (-110) | Moneyline -150

• Jets: Spread +2.5 (-110) | Moneyline +125

• Total: Over/Under 39.5 (-110/-110)

Falcons vs. Jets might not be the flashiest game on the schedule, but there’s plenty of intrigue. Atlanta depends heavily on Bijan Robinson to create big plays, and the Jets' defense is precisely the type of unit that challenges a young offense. 

The Jets haven’t been able to score much this season, and this should bite them here. The Falcons will score a little too much to beat the Jets. 

Cardinals vs. Buccaneers Odds, Sunday, 1:00 PM EST

• Cardinals: Spread +3.0 (-110) | Moneyline +135

• Buccaneers: Spread -3.0 (-110) | Moneyline -160

• Total: Over/Under 44.5 (-110/-110)

Baker Mayfield injured his shoulder last Sunday night against the Los Angeles Rams. If Mayfield isn’t on the field, the Cardinals have a great chance to shut down the Buccaneers. 

Tampa Bay has been riddled by injuries all season, and it’s starting to cause them to lose consistently. 

Tampa’s defense always seems to play with extra energy at Raymond James Stadium. Arizona has the explosiveness to make this game close, but Tampa Bay’s balance gives them the inside track.

Rams vs. Panthers Odds, Sunday, 1:00 PM EST

• Rams: Spread +10.0 (-110) | Moneyline -600

• Panthers: Spread -10.0 (-110) | Moneyline +450

• Total: Over/Under 46.0 (-110/-110)

The Rams head to Carolina, and they have the NFL MVP candidate at quarterback in Matthew Stafford. Their offense is always tough to stop, and the Panthers don’t have much of a chance to get stops. 

Carolina usually plays better defensively at home, so the Rams may have to be patient. Hosuperwever, it’s hard to see Carolina doing what is needed to win over four quarters. 

Los Angeles just rolled the Buccaneers, and Tampa Bay is a better team than Carolina. 

Vikings vs. Seahawks Odds, Sunday, 4:05 PM EST

• Vikings: Spread +10.5 (-115) | Moneyline +425

• Seahawks: Spread -10.5 (-105) | Moneyline -575

• Total: Over/Under 41.0 (-110/-110)

Seattle home games just feel different, and that alone makes life tough on opponents. Sam Darnold Smith has been steady, and Jaxon Smith-Njigba remains a constant mismatch. 

Minnesota’s season depends heavily on whether they can find a rhythm at quarterback, and they’ll be without JJ McCarthy because of a concussion. 

The Vikings still have talent, especially on defense, but Seattle’s environment gives them a real edge. If Minnesota can weather the early storm, this could be fun.

Bills vs. Steelers Odds, Sunday, 4:25 PM EST

• Bills: Spread -3.5 (-115) | Moneyline -205

• Steelers: Spread +3.5 (-105) | Moneyline +170

• Total: Over/Under 47.5 (-110/-110)

Buffalo travels to Pittsburgh on Sunday, and they’ll look to respond after getting rolled by the Texans in Week 12. Josh Allen will try to create chunk plays through the air and on the ground, while the Steelers hang around with their pass rush and physical style. 

Pittsburgh’s offense has been inconsistent, but its defense tends to keep them in games at home. If Buffalo avoids turnovers, they’re the more explosive team, and this will lead to a win. 

Raiders vs. Chargers Odds, Sunday, 4:25 PM EST

• Raiders: Spread +9.5 (-110) | Moneyline +400

• Chargers: Spread -9.5 (-110) | Moneyline -550

• Total: Over/Under 41.0 (-110/-110)

Any time the Raiders and Chargers meet, the stadium feels split down the middle, which makes the whole thing a little unpredictable. Justin Herbert continues to be one of the most gifted quarterbacks in the league, but he’s also inconsistent. 

The Chargers offense can explode, but it’s always a guess heading into games.

On the other hand, the Raiders are the worst team in the NFL, and they just fired their offensive coordinator, Chip Kelly. 

Broncos vs. Commanders Odds, Sunday, 8:20 PM EST

• Broncos: Spread -6.5 (-110) | Moneyline -300

• Commanders: Spread +6.5 (-110) | Moneyline +240

• Total: Over/Under 43.5 (-110/-110)

Sunday Night Football gives us Broncos vs. Commanders, and both teams enter with something to prove. Bo Nix has settled in and found a nice connection with his receivers, giving Denver a steadier offense. 

The Commanders need to prove that they’re still competitive. This is a great chance to take down one of the best teams in the AFC. 

These teams aren’t evenly matched, which should lead to a lopsided Broncos win. 

Giants vs. Patriots Odds, Monday, 8:15 PM EST

• Giants: Spread +7.5 (-115) | Moneyline +320

• Patriots: Spread -7.5 (-105) | Moneyline -400

• Total: Over/Under 46.5 (-110/-110)

Week 13 wraps up with the Giants versus the Patriots, and these two teams are in different spots. The Giants are trying to improve their young players, whereas the Patriots are ready to compete right now. 

Drake Maye is second in the MVP race, and he has been fantastic all season. New England’s offensive line is very beat up, and this should make a difference against the Giants' front. 

New England has to slip up, and this feels like the spot for it to happen.

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