AFC Championship Predictions & Odds Bills vs Chiefs 2021

NFL 2020 AFC Championship - Predictions & Odds

  • The Buffalo Bills easily took care of Lamar Jackson’s Ravens last week, final score 17-3
  • Chiefs star QB Patrick Mahomes has cleared all the “big steps” of concussion protocol
  • These AFC rivals last played in Week 6 when the Chiefs beat the Bills, final score 26-17

New Users Only. Min. $5 Deposit. Eligibility restrictions apply. See for details.

  • tick mark20K public contests per day
  • tick markPlay against friends privately
  • tick markWin even if you don't finish 1st

New Users Only. Min. $5 Deposit. Eligibility restrictions apply. See for details.


21+ | T&Cs apply

  • tick markFree play options
  • tick markSpecial contests for newbies

21+ | T&Cs apply

21+ | T&Cs apply

  • tick markUse bonus code WSN50
  • tick mark2nd half contests
  • tick markBeginner friendly

21+ | T&Cs apply

AFC Championship Odds Bills vs Chiefs

Odds taken January 22, 2021, from DraftKings Sportsbook

To Win the AFC Championship in 2021Odds
Kansas City Chiefs-167
Buffalo Bills+145

Odds from DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or check out more offers and promo codes for the best online sportsbooks.

Bills vs Chiefs Predictions and Picks

The Chiefs have “hope and optimism” that Mahomes will play in this one, so expect the team to go about their postseason business as usual and take care of these talented Buffalo Bills by more than a field goal.

For more predictions on this weekend’s championships head to NFL Conference Championships Picks Against the Spread.


Chiefs -3 (-104)

If you’re not sure which sportsbook to use to bet on the AFC Championship, have a look at our compilation of the best NFL football betting bonuses offered by US sportsbooks.

How to Watch AFC Championship

Bills vs Chiefs AFC Championship Information
WhatBuffalo Bills vs Kansas City Chiefs
WhereArrowhead Stadium in Kansas City, MO
WhenSunday, January 24, 2021; 6:40 PM ET
How to watchCBS

The Buffalo Bills young quarterback Josh Allen threw for an impressive four TD passes with no interceptions in the teams’ divisional playoff win over the Ravens, Allen benefiting from a receiving corps that includes three standout starters – Stefon Diggs, John Brown, and Cole Beasley – a receiving corps that could take full advantage of a Chiefs defense that can struggle against the pass.

According to the Chiefs, their star quarterback Patrick Mahomes has cleared all the “big steps” of concussion protocol after leaving the game last week due to a head injury, though head coach Andy Reid has full confidence in his 35-year old veteran backup, Chad Henne, who got the win last week but who is no Mahomes, and against these Bills, that matters big time.

These two AFC franchises have played each other 49 previous times (including 3 postseason games), with the Kansas City Chiefs winning 22 of those games and the Buffalo Bills winning 26 of the games, plus they have also tied once.

Can the Bills Defense Handle the Chiefs Passing Attack?

When it came to stopping the pass during the regular season, the Buffalo Bills did an okay job of it, ranked 13th among all 32 teams after keeping opponents to just 233 yards through the air per game.

That might not be possible against the Chiefs if they can start Mahomes on Sunday, and all eyes will be on Buffalo’s talented secondary to cover KC’s speedster Tyreek Hill and possibly Sammy Watkins (still listed as questionable with a calf injury).

Should be a big game for CBS Tre’Davious White and Levi Wallace and S Jordan Peter and FS Micah Hyde, and if they can manage to stay tight on the ‘Cheetah’ (Hill) somehow, it could help get their QB Josh Allen back on the field more quickly.

Can Chiefs QB Patrick Mahomes Pass Through Concussion Protocol?

Bills vs Chiefs Odds

The Chiefs’ star quarterback Patrick Mahomes is now dealing with two serious issues with his body – he suffered a foot injury and a concussion last week in the team’s divisional matchup with the Cleveland Browns.

Both of these injuries have left Mahomes listed as questionable for Sunday, making him a game-time decision by coach Andy Reid, though the team told the media on Tuesday that Patrick had passed some “big steps” in his concussion protocol and that there is “hope and optimism” that he will be able to play on Sunday.

His backup, Chad Henne, proved last week he could get the job done if needed, but these Bills have had time to game plan around his tendencies, so he might not be as effective against Buffalo, a huge gamble that the returning champs cannot afford to take, and hopefully won’t have to.

Editor’s Picks

Bills Key Player: (RB) Devin Singletary

In just his second professional year, running back Devin Singletary has proven to be an essential part of the Bills offensive attack, so far this season has carried the ball 151 times for 687 yards and 2 touchdowns on top of catching 38 passes for 269 more yards.

The Bills rely on QB Josh Allen’s thunderous (and often accurate) throwing arm for much of their offensive production, but in the postseason, they need their run game to step up, so far averaging just 64 yards of rushing in each of their two playoff games thus far.

Singletary hasn’t run for a touchdown since Week 15 of the regular season, so he is due to find the end zone soon, and against this Chiefs defense, he could have a big game if head coach Sean McDermott can work him into the game plan.

Chiefs Key Player: (RB) Clyde Edwards-Helaire

One thing missing in the Chiefs’ offensive attack last week was star rookie running back Clyde Edwards-Helaire, who could not play due to an ankle injury that has him still listed as questionable for this Conference matchup on Sunday.

Regardless of whether Mahomes can suit up (see above), the Chiefs need a solid run game to counter-balance their famed passing attack, and last week RB Darrel Williams had to make 13 carries and averaged 6 yards per, totaling 78 yards but no touchdowns.

Best Promo Codes and Bonuses for Bills vs Chiefs

Check out the best sportsbooks for betting on Bills vs Chiefs in your state:

Check out our NFL Pick ’em Contest and get a chance to win $200!

AFC Championship Winners

Team# of AFC Championships
Pittsburgh Steelers16
New England Patriots15
Las Vegas / Los Angeles / Oakland Raiders11
Denver Broncos10
Miami Dolphins7
Baltimore / Indianapolis Colts7
Buffalo Bills5
Houston Oilers / Tennessee Titans5
Baltimore Ravens4
Los Angeles / San Diego Chargers4
New York Jets4
Kansas City Chiefs3
Jacksonville Jaguars3
Cleveland Browns3
Cincinnati Bengals2
Seattle Seahawks1
Houston Texans0
Tampa Bay Buccaneers0


When is the AFC Championship game?

The 2021 AFC Championship game between the Bills and the Chiefs is played in Kansas City on Sunday, January 24, 2021; at 6:40 PM ET.

What channel is the AFC Championship game on?

The AFC Championship 2021 game between the Buffalo Bills and the Kansas City Chiefs will be shown on CBS at 6:40 PM ET.

More NFL Futures Predictions & Odds

More NFL Futures Predictions & Odds

NFC Championship 2021 Predictions & Odds Buccaneers vs Packers
NFC Championship 2021 Predictions & Odds Buccaneers vs Packers
The oddsmakers already have some favorites to win the 2020 / 2021 NFC Championship in the NFL – here are their predictions and odds.
News iconJanuary 21
Author iconMike Lukas
2020/2021 NFL MVP Predictions, Picks & Betting Odds
2020/2021 NFL MVP Predictions, Picks & Betting Odds
Here are the top-5 candidates for the NFL MVP honor in 2020/2021, as well as the predictions and odds associated with each of these five talented players.
News iconJanuary 18
Author iconMike Lukas
Super Bowl LV Predictions & Betting Odds
Super Bowl LV Predictions & Betting Odds
We have the odds and predictions of which teams are expected to win Super Bowl LV, plus the underdogs, also-rans, and our pick.
News iconJanuary 18
Author iconMike Lukas
Avatar for Mike Lukas

Mike Lukas

Expert on NFL

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager.

Email: [email protected]