Best MLB Home Run Predictions Today: Stay Safe with Familiar Faces

After hitting on three of our four home run targets on Tuesday, we’re feeling confident about Wednesday’s picks. Rather than using that confidence to reinvent the wheel, we figured it’s best to keep things simple. We chose four players who are somewhat common and obvious choices to hit home runs.

Of course, with home run props, the obvious choice is often the best.

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Best Home Run Predictions for Wednesday, May 27

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Brandon Lowe Anytime Home Run (+350) at FanDuel Sportsbook

Lowe has flown a little under the radar as one of MLB’s best power hitters this season, hitting 13 home runs. While he has only had one home run in his last 10 games, Lowe is very much in a groove right now. He has four multi-hit games in his last six games, making it inevitable that his power will return.

Of course, the real reason we’re targeting Lowe is that he and the Pirates are facing Jameson Taillon, who leads the big leagues in home runs allowed. Taillon has given up 17 homers this year, allowing at least one in eight of his 10 starts. Left-handed hitters have hit a majority of those home runs against Taillon, which favors Lowe, who already has two career home runs against Taillon in just 14 at-bats. 

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Bryce Harper Anytime Home Run (+470) at FanDuel Sportsbook

Harper went deep on Tuesday, giving him 13 home runs on the season, so we’re going to run it back with him on Wednesday. Admittedly, it’s been a little bit of a struggle for Harper, who has been hitless in five of his last eight games. At the same time, Harper has hit home runs on back-to-back days on two separate occasions this month, so we’ll take a chance on that happening again.

The pitching matchup on Wednesday also favors Harper, as the Phillies face Walker Buehler. In a small sample size, Harper is 4 for 6 with three doubles and a home run in his career against Buehler. While he’s only allowed four home runs this season, Buehler has a 5.05 ERA, and his past troubles against Harper make him vulnerable.

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Yordan Alvarez Anytime Home Run (+260) at FanDuel Sportsbook

Alvarez went deep twice on Wednesday, making him 3 for 8 with three home runs over his last two games. His home runs tend to come in bunches, so we’re going to take a chance on that continuing. Alvarez already has one instance of hitting a home run in three consecutive games this season, so it’s not far-fetched that he can do it again.

In theory, Alvarez and the Astros have a tough matchup against Jacob deGrom on Wednesday. But deGrom has been unusually vulnerable to the long ball this year, giving up 12 home runs over his 10 starts. More importantly, Alvarez has an unreal track record against deGrom, going 12 for 23 with three doubles and two home runs against one of this generation’s best pitchers, making us unafraid to target Alvarez on Wednesday.

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Julio Rodriguez Anytime Home Run (+330) at FanDuel Sportsbook

Rodriguez had just two home runs at the end of April, but he’s enjoyed a great May, already hitting seven home runs, making now a good time to target him. He’s had at least one hit in seven of his last eight games, accumulating four extra-base hits and three multi-hit games during that stretch. Clearly, he’s trending in the right direction at the moment.

On Wednesday, Rodriguez and the Mariners go up against the A’s Jeffrey Springs. Rodriguez is batting .300 and slugging .633 against lefties this year, hitting six of his nine homers against southpaws in far fewer at-bats. Likewise, Springs has allowed 11 home runs, eight of which have been hit by right-handed hitters. Rodriguez also has two previous homers in 14 career at-bats against Springs, making this a favorable matchup for him.

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