Buffalo Bills vs Kansas City Chiefs Week 6: The Bills Have the Best Offense

• The Buffalo Bills have ten players listed as questionable to play in Week 6
• The KC Chiefs survived a come-from-behind victory last week over Las Vegas, 30-29
• Watch Bills vs Chiefs live on Sunday, October 16, 2022, at 4:25 PM ET on CBS

Bills vs Chiefs Week 6 Odds

The odds in the table below are provided by DraftKings, BetRivers, and FanDuel. Click on “Bet Here” to head to the sportsbooks and place your bet.

Bills vs Chiefs Week 6 Picks

POINT SPREAD: Kansas City Chiefs +1.5 (-110) at DraftKings

POINTS TOTAL: Over 47.5 (-110) at FanDuel

MONEY LINE: Buffalo Bills (-125) at BetRivers

What a thrilling game this promises to be as two of the league’s top teams face off at Arrowhead Stadium with the 4-1 Buffalo Bills going head to head with the 4-1 Kansas City Chiefs, or more accurately it is QB Josh Allen challenging Patrick Mahomes to a Week 6 AFC fight with only one winner allowed.

The KC Chiefs survived a come-from-behind victory last week over the Las Vegas Raiders by a tight score of 30-29, a game in which TE Travis Kelce caught four TD passes, a major offensive weapon who will dare the banged up Bills secondary to cover him – something that Vegas could not figure out – that job probably going to CB Dane Jackson who should get lots of safety help.

The Bills have the best offense and the second-best defense in the league right now, and they are 4-1 on the season and on a two-game winning streak, this being the last game before their Week 7 bye so even the injured players will most likely suit up, game oddsmakers expect to be a close one so might as well take the home team and the points here and hope they’re right.

POINTS TOTAL: Over 47.5 (-110) at FanDuel

These are the top two scoring teams in the NFL this season so we are going to be looking at the overbet here, a choice made easier when you look at what these teams typically score every week – the Bills averaging 30.4 points and the Chiefs averaging 31.8 points per game – a whopping 62.2 total that far exceeds the over here.

However, it is important to note that right now the Bills are best in the league at keeping opponents out of the end zone allowing just 12.2 points per game whereas the Chiefs’ defense is ranked 24th in that same category after allowing teams to score 25 points per game, that 37.2 total an indicator that if these two defenses play well then the under becomes the surer bet.

A big factor in scoring could come down to having a healthy enough roster to get the job done on either side of the ball, and right now the Buffalo Bills have ten players listed as questionable to play in Week 6 including six on defense which could give the Chiefs more opportunities to score as HCs Sean McDermott and Andy Reid do battle to see which one can outwit the other.

MONEY LINE: Buffalo Bills (-125) at BetRivers

After watching the Chiefs almost get beaten by the Raiders last MNF, it seems clear they are still learning how they work best in their current post-Cheetah configuration that gives QB Mahomes no surefire deep threat, though TE Kelce’s midrange production does help as Marquez Valdes-Scantling and JuJu Smith-Schuster step up.

Here is how the money line will work for this potentially close matchup – bet $100 on the Chiefs to win $105 plus your bet or wager $125 on the Bills to win $100 and your original investment, not quite a wash but close enough to have a chance on either side, with those injuries most likely coming into play later in the game as each team tires out and roster depth gets tested.

Some fun matchups to watch for – Bills playmaking WR Stefon Diggs being covered by CB Rashad Fenton with safety help from Justin Reid and Juan Thornhill; also watch for Chiefs RB Clyde Edwards-Helaire as he faces the Bills 2nd ranked run defense that keeps opposing backs to just 77.8 yards per game, with KC’s rushing attack a key element of their weekly game plan.

How to Watch Bills vs Chiefs

• What: Buffalo Bills vs Kansas City Chiefs
• Where: GEHA Field at Arrowhead Stadium in Kansas City, MO
• When: Sunday, October 16, 2022, at 4:25 PM ET
• How: CBS