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Buffalo Bills vs Tennessee Titans Predictions, Odds, Picks MNF

Written by: Mike Lukas
Updated October 14, 2022
15 min read
  • The Buffalo Bills took down the KC Chiefs last week, 38-20, and QB Josh Allen ruled
  • Titans RB Derrick Henry carried the ball 29 times for 130 yards and 3 TDs in Week 5
  • The Bills have won 14 of their last 15 games as ‘moderate’ favorites

Bills vs Titans Odds

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Bills vs Titans Point Spread Money line Total
Bills -5.5 (-110)
O 52.5 (-110)
Titans +5.5 (-110)
U 52.5 (-110)

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Bills Vs Titans Nfl Week 6

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The Buffalo Bills took down the KC Chiefs last Sunday night, 38-20, and quarterback Josh Allen showed off MVP qualities with three touchdowns after completing 15 passes for 315 yards and no turnovers, and now Allen and best friend tight end Dawson Knox are also bonding on the field, connecting 3 times for 117 yards and a touchdown in that win over the Chiefs.

Last week Tennessee Titans impossible-to-tackle running back Derrick Henry helped his team pummel the Jacksonville Jaguars, 37-19, while carrying the ball 29 times for 130 yards and three touchdowns, his quarterback Ryan Tannehill also shining by completing 14/22 passes for almost 200 yards and a touchdown with no picks, certainly a tough squad to outscore.

These two AFC rivals have met each other 48 previous times (including 3 postseason games), with the Tennessee Titans winning 29 of those games and the Buffalo Bills winning 19 of the games.

Buffalo Bills vs Tennessee Titans Predictions

Can the Bills Defensive Front Neutralize Titans RB Derrick Henry?

So far in 2021, the Buffalo Bills have the top-ranked defense after allowing opponents to gain just 252 yards against them per game, plus they have been holding the teams that they play to less than 13 points each time.

Buffalo is third-best against the run, allowing opponents to carry the ball for about 78 yards a game, pressure they will need while facing Tennessee’s starting running back Derrick Henry who has been a 100+ yard back in four of his five games this season.

One key to tackling Derrick Henry is to not attempt it alone, his ability to gain yards after first getting hit is embarrassing to defenders, but if the Bills can do that it could cripple these Titans who at times can field a one-dimensional offense.

Can the Titans Secondary Stop the Bills Killer Passing Attack?

Currently, Tennessee’s pass defense is in the bottom third of the league (21st), so against Josh Allen and his killer receiver corps – Emmanuel Sanders, Stefon Diggs, Cole Beasley, and TE Dawson Knox – that could spell trouble.

The Titans allow whoever the play to throw for almost 265 yards a game, which is just under what Buffalo (270 yards per) has been averaging this season, so this could come down to which team plays the cleaner game, meaning the fewest turnovers and penalties.

Bills QB Josh Allen has only been sacked five times this season, so if Tennessee’s defensive front – end Denico Autry and tackles Teair Tart and Jeffrey Simmons – can get to him once or twice, that could change the entire course of this game.

Bills Key Player: (FS) Micah Hyde

Yes, Buffalo must stop Titans RB Derrick Henry, but they also must neutralize their quarterback Ryan Tannehill who has been completing almost 64 percent of his passes for 1,250 yards and 6 touchdowns this season with just 3 interceptions on the year.

Enter Bills free safety Micah Hyde, the six foot 197 pound beast now in his ninth NFL season – he has also played for the Green Bay Packers – who currently has the second most interceptions in the league with three, one of those brought back for a touchdown.

Hyde can also tackle, so far with 21 combined this season, plus he has posted a sack and a hit on the quarterback with five passes defended, production that should come in handy against whatever the Titans bring.

Titans Key Player: (RB) Derrick Henry

Once again, Titans running back Derrick Henry is showing why he was last year’s best running back in the NFL, so far in 2021 having four games with 100+ rushing yards, his best in Week 2 when he ran for 182 yards and three touchdowns.

Now in 2021, Henry is leading the league in multiple categories including carries (142), total rushing yards (640), rushing touchdowns (7), and yards per game (128), mind-blowing totals in just five weeks.

So watch for Henry to have yet another fine outing, though maybe Buffalo can somehow stop him the way the Cardinals did in Week 1 when he was kept to just 58 yards and no touchdowns, a rare weak outing for a man who looks to again be the NFL’s most productive rusher by a longshot.

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How to Watch Bills vs Titans

Bills vs Titans Information
What Buffalo Bills vs Tennessee Titans
Where Nissan Stadium in Nashville, TN
When Monday, October 18, 2021; 8:15 PM ET
How to watch ESPN
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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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