When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

Indianapolis Colts vs Tennessee Titans Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
8 min read
Colts Vs Titans 2020 11 12
  • Indy Colts QB Philip Rivers threw 0 TDs and 1 INT in a Week 9 loss to the Ravens
  • The Titans beat the Bears in Week 9 despite Tennessee’s D collapsing in the 4th quarter
  • Colts and Titans split their games in 2019, final scores: IND 19-TEN 17; TEN 31-IND 17

Colts vs Titans Odds

Find the latest NFL predictions and picks weekly on WSN.

Team Point Spread Odds
Indianapolis Colts +1
Tennessee Titans -1


Odds from DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or check out more offers and promo codes for the best online sportsbooks.

Colts vs Titans Predictions and Picks

The Colts have the third-best defense against the run and the pass, but Derrick Henry and Ryan Tannehill will find a way to score despite that in Week 10 and squeak by these talented Colts, whose offense might not be able to trade equal punches in this one.


Titans -1 (-110)

How to Watch Colts vs Titans

Colts vs Titans Information
What Indianapolis Colts vs Tennessee Titans
Where Nissan Stadium in Nashville, TN
When TNF Thursday, November 12, 2020; 8:20 PM ET
How to watch FOX / NFLN

It was not a fun Week 9 for the Indianapolis Colts and their veteran QB Philip Rivers with the team taking the loss to the Ravens and Rivers throwing a pick and zero TDs and the offense failing to score at all in the second half of that game, final score 10-24.

Titans RB Derrick Henry was held to just 68 yards off 21 rushes last week (3.2 yds per carry), yet still, Tennessee got the win over the Chicago Bears, 24-17, with WR A.J. Brown catching 4 passes for 101 yards and a touchdown.

These two AFC South rivals have met each other 51 times (including 1 postseason game), with the Tennessee Titans winning 17 of those matchups and the Indianapolis Colts winning 34 of those games.

Find the best promo codes and our Week 10 bonuses, here!

Can the Colts Offense Show Up in Week 10?

The Colts scored a touchdown in the first quarter of Week 9’s loss to the Baltimore Ravens, and then after that is was a field goal in the second quarter and then a fat goose egg for the rest of the game, a lapse in offense that can be blamed, at least partially, on QB Philip Rivers.

Rivers stats line was a bit sad – completed 25-of-43 for 227 yards, no touchdowns, and an interception – especially given that the veteran hurler was brought in this season to get the Colts lackluster offense in gear.

Indianapolis will also need to see more effectiveness from its run game, right now ranked 23rd in the NFL in overall production, their rookie RB Jonathan Taylor having to shoulder quite a bit of responsibility for a first year player, so far averaging 3.9 yards per carry this season.

Can Titans RB Derrick Henry Rebound After a ‘Mediocre’ Week 9?

For star RB Derrick Henry, Week 9 was ‘mediocre’ since he only posted 68 yards off 21 carries with no touchdowns, output that is well under what the team typically expects for their number one back.

Henry averaged just 3.2 yards per rush in that one, as compared to his 2020 season average of 4.6, and right now he leads the league in overall carries with 183, which has translated into 843 yards on the ground and 8 touchdowns with no fumbles this year.

The Colts are third-best in the league against the run, way tougher than those Bears that just shut Henry down last week, so it will take a big game in Week 10 by him to help lift this Titans team to their 7th win and remain high atop the AFC South.

Editor’s Picks

Colts Key Player: (WR) Rookie Michael Pittman Jr.

Colts rookie wide receiver Michael Pittman had the best game of the season last week against the Baltimore Ravens, catching four balls for 56 yards, averaging and impressive 14 yards per reception.

Right now, QB Rivers needs all the targets he can get, and if Pittman can begin to be a reliable set of hands for him, the former USC Trojan can find himself on the field a lot more than he has been, mostly due to injury.

Pittman was placed on injured reserve on October 3 due to compartment syndrome in his calf, but he has activated again on Halloween.

Titans Key Player: (QB) Ryan Tannehill

QB Ryan Tannehill is proving to be everything the Titans had hoped he would be when they gave him a four-year extension worth $118 million back in March that featured $62 million guaranteed.

So far, Tannehill is 6-2 on the season and has completed a respectable 65.7 percent of his passes, and has a passer rating of 109.4, with 91 touchdown passes and just 3 interceptions on the season.

Tannehill is key to a win against these divisional rival Colts, their 3rd ranked pass defense no joke these days, so it would be helpful if WR A.J. Brown had another fine game like he just posted during the team’s Week 10 win, with 4 catches for 101 yards and a touchdown.

Best Promo Codes and Bonuses for Colts vs Titans Week 10

Check out the best sportsbooks for betting in your state:

Image for Mike Lukas


Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

More info on Mike Lukas
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks

© Rebel Penguin ApS 2024 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.