NFL Week 1 Picks Against the Spread: Predictions, Best Picks, Odds

• In a revenge match for the ages, the rising Cleveland Browns take on the risen Chiefs.
• If QB Aaron Rodgers is still playing in Green Bay, his Packers could beat the Saints.
• Many have written off the Pittsburgh Steelers, but they could beat Buffalo Bills in Week 1

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NFL Week 1 Picks Against the Spread Odds

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NFL Week 1 Picks Against the Spread Predictions and Picks

Our bets are on the Browns point spread for NFL opening week. The odds below are provided by William Hill. Click on ‘BET NOW’ to head to William Hill and place your bet. Use bonus code ‘WSNRF‘ to get a $500 RISK-FREE sign-up bonus. Check out our selection of the best NFL betting bonuses.

The NFL odds makers did not waste any time with their Week 1 point spread predictions, and though most of them make perfect sense, there are always a few potential upsets that could be juicy enough to crack open your betting kitty.

In a key Week 1 showdown, Cleveland takes on Kansas City following the Browns losing their first ‘second’ playoff game in forever to Chiefs’ backup QB Chad Henne, and now Baker Mayfield’s bunch look to shut down Patrick Mahomes’ gang with an upgraded secondary that looks Super Bowl-bound.

Other Week 1 underdogs to take a look at are the Green Bay Packers with or without QB Aaron Rodgers, the Arizona Cardinals with their power-packed receiver corps, and ‘antiquated’ Big Ben Roethlisberger’s Pittsburgh Steelers.

NFL Week 1 Predictions and Odds From Bill Krackomberger

Expert sports bettor Bill Krackomberger talks about the betting lines for NFL week 1. Unlike last year there hasn’t been much movement on the lines so Krack advises to start betting now. For more sports betting advice from Bill and Jon have a look at our weekly podcast – Wise Kracks.

How to Watch 2021/22 NFL Regular Season

NFL Week 1 Favorites to Win

Cleveland Browns vs Kansas City Chiefs

whether you’re a fan of one of these two AFC favorites or just an NFL junkie, this Week 1 matchup between the Browns at Chiefs is a head-turner for so many reasons.

It’s a great head coach battle between last year’s COY recipient Kevin Stefanski and Super Bowl Champion Andy Reid plus a head-to-head QB battle between Baker Mayfield and Patrick Mahomes, not to mention how much the Browns have added on defense for just such an occasion.

This early in the season, it’s still anyone’s game, and now that the Browns have had a full offseason to bond with the same offense, coaching staff, and game plans, they could take those points and their now solid secondary and defeat the Chiefs at Arrowhead.

Arizona Cardinals vs Tennessee Titans

This is an interesting matchup because one team is trending up and the other down, with the Cardinals’ HC Kliff Kingsbury and QB Kyler Murray firing on all cylinders these days facing a Titans team whose defense was decimated over the offseason.

Yes, the Titans still have top-notch RB Derrick Henry and speedy receiver A.J. Brown, but they lost offensive coordinator Corey Davis, star tight end Jonnu Smith, and multiple cornerbacks this offseason so they will be working at a total defensive disadvantage in Week 1 especially.

Whereas the Cardinals are hopped up on talented receivers with DeAndre Hopkins, rookie slot receiver Rondale Moore, and now star veteran A.J. Green, so expect QB Kyler Murray to execute the offensive game plan effectively and earn the Week 1 upset.

Green Bay Packers vs New Orleans Saints

Will he or won’t he is the question, and quarterback Aaron Rodgers and his lack of faith in the Green Bay front office will play a big part in determining the answer to whether the unhappy veteran QB will ever suit up in a Packers’ uniform again.

If he does play in Week 1 for Green Bay, Rodgers, who feels his GM doesn’t give him the weapons he needs to go deep in the playoffs, will be facing a Drew Brees-less Saints team at their New Orleans home, the Saints now with either gadget play specialist Taysom Hill or the interception-prone Jameis Winston under center.

It’s an interesting bet to make this early since there is still no telling whether Rodgers will stay or go but give him a few points and have him face a newly led offense and it could be good money to place a wager on him.

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NFL Week 1 No Chance to Win

Pittsburgh Steelers vs Buffalo Bills

Everybody that doesn’t live in Pittsburgh seems to have written off the Steelers after their late-season downwards spiral and failure to beat their nemesis Cleveland Browns in the playoffs last season.

Many blame the declining and surgically repaired throwing arm of Steelers veteran QB Ben Roethlisberger for their series of end-of-season losses, letting four of their last five matchups get away from them after starting the season off 11-0.

Now what could ruin this longshot bet fast is a guy named Josh Allen, the Buffalo Bills franchise QB with a rocket arm and a growing football IQ who would have to start out slowly despite the Bills having won their first four games last season, so maybe watch Big Ben in the preseason and make sure he’s still up for the task.