NFL Playoffs Divisional Picks Against the Spread Predictions, Best Picks, Odds

  • Get the most recent odds for NFL Divisional Playoff Round Games in 2022
  • Our top predictions and picks for the season’s second week of postseason games
  • View stats from past seasons to help give you an edge over the sportsbooks

Out of the thirty-two teams that played in the regular NFL season, only eight remain after the Wildcard playoff round did what it is meant to do – expose and eliminate the paper lions – leaving just four more matchups in the Divisional Playoff Round to sort out which two franchises will play for the Lombardi Trophy in the Super Bowl.

Three of the NFL playmaking quarterbacks most associated with the postseason are still here, including Tom Brady, Aaron Rodgers, and Patrick Mahomes, plus now there are young superstars competing from under center like the Bill’s Josh Allen and the Bengal’s Joe Burrow.

The winners of these Divisional Round battles move on to the Conference Championship games, where the best four teams in the league fight it out to represent the AFC and NFC in the Big Game, that chance to win a Super Bowl ring the goal of every player, coach, GM, and owner in the league.

Here are our best predictions, picks, spreads, and odds of the four NFL Divisional Playoff Round games – good luck, win big!

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Divisional Playoffs

AFC and NFC Divisional Playoffs Saturday, January 22

Cincinnati Bengals vs Tennessee Titans (-2.5)

How to watch: Saturday, 4:30 PM ET, CBS

The incredible and historic season continues for the Cincinnati Bengals led by their young HC Zac Taylor who has made the most of his youthful superstars including QB Joe Burrow and WR Ja’Marr Chase, a duo who have their Bengals passing attack ranked 7th in the league, though it might be Cincy’s 5th ranked run defense that saves the day against Titans’ RB Derick Henry.

The Tennessee Titans lost star RB Derrick Henry (Jones Fracture) early on but still, HC Mike Vrabel’s game plan held steady as his team ended up winning twelve games, and now that a healthy Henry has returned to the lineup (the #1 seeded Titans had a playoff bye week to work him back in), expect QB Ryan Tannehill and company to keep the Bengals on a short leash.

This game could be a close one and since the Bengals have covered the spread their last five games, pick them to do it here against the Titans.


Bengals +3 (-100)

San Francisco 49ers vs Green Bay Packers (-5.5)

How to watch: Saturday, 8:15 PM ET, FOX

The San Francisco 49s used a solid rushing attack led by rookie RB Elijah Mitchell (27 carries, 96 yards, TD) to get past the Cowboys last week, 23-17, and now veteran QB Jimmy Garoppolo has yet another week to prove he has what it takes under center to win playoff games for whatever NFL team will have him next, his WR Deebo Samuel now a huge part of their offense.

A well-rested Green Bay Packers playing in front of their Lambeau Field hometown crowd are tough to beat (they’re 15-1 at home over the last two seasons), so expect QB Aaron Rodgers and his favorite target WR Devante Adams top come out firing as their top-9 defense continues to keep the other team off the field, a combination that led to thirteen wins in the regular season.

As tough as the Niners pass rush starring Nick Bosa is, expect QB Rodgers and his Packers to get past this San Fran team and cover the postseason spread.


Packers -5.5 (-110)

NFC and AFC Divisional Playoffs Sunday, January 23

Los Angeles Rams vs Tampa Bay Buccaneers (-3)

How to watch: Sunday, 3:00 PM ET, NBC

The NFC’s fourth-seeded Los Angeles Rams made easy work of the 5th seeded Arizona Cardinals on the first-ever Monday Night Wildcard weekend broadcast, 34-11, a game that featured a solid passing attack by QB Matthew Stafford who hit both Cooper Kupp and Odell Beckham Jr. for touchdowns, but it is the Rams’ defense that makes this team truly dangerous.

Last week, the Tampa Bay Buccaneers easily took care of the Philadelphia Eagles, 31-15, in a game that was a warmup for the returning Super Bowl Champs, their QB Tom Brady no stranger to the postseason, with two of his remaining offensive targets – WR Mike Evans and TE Rob Gronkowski – healthy and HC Bruce Arians’ D able to keep opponents off the field.

Until he proves otherwise, it’s best not to bet against the GOAT, so take Tom Brady and his Bucs to cover the spread here.


Buccaneers -3 (-110)

Buffalo Bills vs Kansas City Chiefs (O55)

How to watch: Sunday, 6:30 PM ET, CBS

This should be a classic QB matchup between two of the NFL’s most talented under center, with the Buffalo Bills’ Josh Allen the third most productive at his position this season, and don’t forget his Bills have the number one ranked defense that has kept opponents to just 17 points per game, a team loaded with talent on both sides of the ball ready to beat KC like they did in October.

The 14-2 Kansas City Chiefs have the number one ranked QB this season, Patrick Mahomes, a playmaker who is dangerous with his arm and on the run, his third-ranked offense starring two of the league’s fastest receivers – Tyreek ‘Cheetah’ Hill and Mecole Hardman – and HC Andy Reid knows how to use them, a team whose 27th ranked defense has been much improved.

Kansas City’s last six games have gone over the total points line so expect them to do that with the high-scoring Bills here.


O55 (-110)

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Mike Lukas

Expert on NFL

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]