Best MLB Bets This Weekend | MLB Picks, September 16-17

We are getting an increasingly clear picture as to which MLB teams are going to the playoffs and which are not this season. But whether a team is playoff bound are getting set to start their offseason in a couple of weeks, there are plenty of chance to take advantage of the MLB betting markets out there, including these best bets for the weekend.

Washington Nationals vs Milwaukee Brewers

• Time: Saturday, September 16 at 7:10 PM ET
• Starting Pitchers: Trevor Williams vs Corbin Burnes
• Moneyline: Nationals (+220) | Brewers (-270)
• Runline: Nationals +1.5 (+105) | Brewers  -1.5 (-125)
• Total: Over 8 (-110) | Under 8 (-110)

Odds courtesy of DraftKings Sportsbook. Check out other MLB betting sites for more betting opportunities

My Pick: Brewers -1.5 (-125)

First up on our list of MLB best bets this weekend is a matchup between the Washington Nationals and the Milwaukee Brewers. Milwaukee is starting to close in on the NL Central title at this point in the season. We like them to move a step closer to achieving that goal and covering the runline as a favorite on Saturday against the Washington Nationals at home.

Milwaukee has Corbin Burnes on the mound for this matchup against the Nationals, which is a great sign for the Brew Crew. Burnes is only 9-8 this season, but he has a more than respectable 3.47 ERA and has piled up 180 strikeouts on the season so far. He will give the Brewers a huge advantage on the mound given that Trevor Williams has really struggled in 2023.

Williams enters Saturday’s action with a 6-10 record for the season and an ERA of 5.44. He has allowed 34 home runs this season in 139 innings of work, which averages out to a home run every four innings or so. Look for the Brewers offense, which has been better in the second half of this season, to wake up and punish Williams in this contest.

Boston Red Sox vs Toronto Blue Jays

• Time: Saturday, September 16 at 3:07 PM ET
• Starting Pitchers: Chris Sale vs Chris Bassitt
• Moneyline: Red Sox (+110) | Blue Jays (-130)
• Runline: Red Sox +1.5 (-182) | Blue Jays -1.5 (+150)
• Total: Over 8.5 (-114) | Under 8.5 (-106)

Odds courtesy of FanDuel Sportsbook.

My Pick: Blue Jays Moneyline (-130)

Next on our MLB best bets for this weekend is an AL East matchup between the Boston Red Sox and Toronto Blue Jays. The Blue Jays are still fighting for a postseason spot through the AL Wild Card race, and they have a chance to get a big win at home against the Sox. We like them to do just that, as the Red Sox have been playing some terrible baseball of late.

Boston has won just two of their last 10 games coming down the stretch, as they have dropped into last place in the AL East standings. Here, they have Chris Sale on the mound for this contest, who has a 4.88 ERA for the season despite having a winning record on the year. Against Chris Bassitt, Sale will put his team at a disadvantage against Toronto at Rogers Centre.

This season, Bassitt has gone 14-8 and has posted a 3.83 ERA during hs 2023 campaign. While Bassitt has allowed 26 home runs this year, which is a little on the high side, he has been solid overall and that should be enough for the Jays to beat the Red Sox.

Minnesota Twins vs Chicago White Sox

• Time: Sunday, September 17 at 2:10 PM ET
• Starting Pitchers: Sonny Gray vs Dylan Cease
• Moneyline: Twins (-148) | White Sox (+124)
• Runline: Twins -1.5 (+114) | White Sox +1.5 (-135)
• Total: Over 8.5 (-118) | Under 8.5 (-102)

Odds courtesy of DraftKings Sportsbook.

My Pick: Under 8.5 (-102)

On Sunday, AL Central foes will square off when the Minnesota Twins take on the Chicago White Sox. We are in for a treat of a pitching matchup in this game, as Sonny Gray and Dylan Cease will take the hill for their respective clubs. Here, we like the game to go under its total of 8.5 runs, as we should get some respectable performances out of both starters in Chicago.

So far this season, both Gray and Cease are both 7-7 on the year, though Gray has much better individual numbers than Cease. Gray’s ERA is at 2.96 heading into his start on Sunday, while Cease’s ERA sits at 4.87. But Cease still has a high enough ceiling whenever he pitches to match low numbers with Gray in this game, and we should see this game fall short of nine total runs by the end.