Arizona Cardinals vs Seattle Seahawks Predictions, Odds, Picks

Written by: Mike Lukas
Updated October 14, 2022
5 min read
  • Whether Cardinals injured quarterback Kyler Murray (ankle) plays is “going to be close”
  • In Week 10, Seahawks’ QB Russell Wilson posted a 50% completion rate and two picks 
  • Seattle’s last seven games have gone under the total points line

Cardinals vs Seahawks Odds

Odds from PlaySugarHouse. Click on the links below to head to the sportsbook and place your bet.

Cardinals vs Seahawks Odds Point Spread Points Total Money Line
Arizona Cardinals -2.5 (-114)
O49.5 (-108)
Seattle Seahawks +2.5 (-107)
U49.5 (-113)

Have a look at all the Week 11 NFL game predictions and picks against the spread.

Cardinals vs Seahawks Pick

The Cardinals offense needs Murray to win, and he will most likely sit out until after their Week 12 bye, so take the Seahawks and the points at home. (+120)

Cardinals Vs Seahawks

When asked on Monday if injured Arizona Cardinals franchise QB Kyler Murray (ankle) will be able to suit up in Week 11, head coach Kliff Kingsbury told reporters, “It’s going to be close,” so keep an eye out because otherwise it will once again be up to Arizona’s 4th ranked defense to ensure a win while receivers A.J. Green and DeAndre Hopkins work with the backup hurler.

In Week 10, Seattle Seahawks’ quarterback Russell Wilson posted a 50% completion rate and two picks while playing with a recently repaired finger, so hopefully, his rehab is now complete and the rust is totally gone after that shut out by Green Bay, 0-17, but nothing Wilson does matters so long as Seattle’s 31st ranked defense fails to stop opponents from outscoring them.

These two NFC West rivals have played each other 44 other times, with the Seattle Seahawks winning 22 of those games and the Arizona Cardinals winning 21 of the games, plus there has been one tie.

Arizona Cardinals vs Seattle Seahawks Predictions

Can Cardinals Quarterback Kyler Murray (ankle) Get Back on the Field?

There is a quarterback issue in Arizona thanks to Kyler Murray’s injured ankle and backup Colt McCoy’s pectoral strain, and though both players are listed as questionable head coach Kliff Kingsbury says he is “hopeful” Murray can play, and if not McCoy is expected to be fine.

Without Murray last week, the Cardinals lost big to the Carolina Panthers, 10-34, and backup QB Colt McCoy failed to throw any touchdown passes but did manage an interception on 107 total yards with just 11 completions.

The Cards can depend on their run game thanks to James Conner (below) stepping up in injured starter Chase Edmonds’ (ankle) absence, but they need Murray back under center soon if they expect to compete in the postseason.

Can Seahawks QB Russell Wilson Re-Find His Passing Game?

There are few better quarterbacks in the NFL than Russell Wilson, but even the best have trouble throwing the ball right after a pin is removed from a finger in the throwing hand, which is mainly why Wilson looked horrible in his Week 10 return from finger surgery.

But now that rust and rehab have happened and Wilson has had plenty of actual reps to go with all those mental ones he had taken, he should be back to old levels of production, so far completing almost 67 percent of his passes and only throwing one interception before last week.

This Seahawks team depends on Wilson’s leadership and football IQ plus production from his main targets – D.K. Metcalf (below) and Tyler Lockett – so watch for all of them to have a big game if they expect to save their season from hovering at the bottom of the NFC West.

Cardinals Key Player: (RB) James Conner

This is running back James Conner’s first season with the Arizona Cardinals, the fifth-year pro having spent his for four NFL seasons with the Pittsburgh Steelers, and right now he leads the league in rushing touchdowns with eleven.

The 6’ 1” 233 pound Conner is a Pittsburgh alum who is tough to tackle, a dual-threat out of the backfield that this season has carried the ball 125 times for almost 500 yards and 11 touchdowns with 13 catches for 136 yards and another touchdown.

Arizona has a top-8 rushing attack that averages over 125 yards per game, so watch for Conner to play a huge role in this Week 11 matchup with a Seattle defense that’s ranked just 26th against the run.

Seahawks Key Player: (WR) D.K. Metcalf

Having the 6’ 4” 235-pound D.K. Metcalf as a receiver means the quarterback (hopefully Russell Wilson this week) can just throw the ball above his head and let him fight the cornerback for it, a battle that the 23-year-old Metcalf usually wins.

This season is Metcalf’s third in the NFL, and in nine games he has been targeted 64 times and has caught 42 of those passes for over 600 yards and 8 touchdowns, his longest and 84 yarder which was also the longest reception of his career.

For the Seahawks to have any chance against the Cardinals, Metcalf will have to have a huge game like he did in Week 5 against the Rams when he caught 5 balls off 5 targets for 98 yards and 2 touchdowns, D.K. a Gronk-like presence that forces defenses to shift their game plans.

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How to Watch Cardinals vs Seahawks

Cardinals vs Seahawks Information
What Arizona Cardinals vs Seattle Seahawks
Where Lumen Field in Seattle, WA
When Sunday, November 21, 2021; 4:25 PM ET
How to watch FOX
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Mike Lukas

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Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager.
Nationality: American
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