NFC West Odds, Predictions, Betting Picks 2024: Injuries Shake up the Division Title Race

• The San Francisco 49ers are the current betting favorite to win the NFC West division title

• Star wide receiver Brandon Aiyuk suffered a season ending injury in last week’s contest

• The Seattle Seahawks are currently in first place in the division standings with a 4-3 record

As if the San Francisco 49ers could not get more unlucky, the injuries keep piling up after they lost their star wide receiver Brandon Aiyuk to a season ending injury in last week’s contest against the Kansas City Chiefs. Not only did Aiyuk tear his ACL, but Deebo Samuel was also hospitalized for a sickness while George Kittle is dealing with a foot injury. Factor in reigning Offensive Player of the Year award winner Christian McCaffrey still being out and the 49ers are seriously depleted of talent at their skill positions.

With the 49ers as vulnerable as ever, that opens the door for someone else to dethrone them for the NFC West division title. The Seattle Seahawks are the current division leaders with a 4-3 record, yet they are dealing with injuries of their own after DK Metcalf went down with a knee injury and is listed week-to-week. As for the Arizona Cardinals, they continue to win but their glaring holes on defense may hold them back from generating a win streak to help pull away from the rest of the pack.

NFC West Odds 

Odds curtesy of Caesars Sportsbook. By using our exclusive Caesars link, you can receive up to $1,000 back in bonus bets if your first wager loses when you use our promo code WSN1000. 

NFC West Predictions and Favorites to Win 

The San Francisco 49ers may be the heavy favorite to repeat as a division champion, but it will not come easy as the rest of the NFC West has steadily improved.

Seattle Seahawks (+265) at Caesars

With the heavy preseason betting favorite San Francisco 49ers dealing with an abundance of injuries, the door is wide open for the Seattle Seahawks to run away with the division title as the current leaders in the NFC West standings. While the injury to DK Metcalf seems devastating on paper, the Seahawks are deep at receiver with Jaxon Smith-Njigba poised to play a bigger role in the offense during Metcalf’s absence.

Should the Seahawks want to capitalize on their opportunity and build on their lead in the standings, then their defense will need to play at a more competitive level as they currently rank below league average in Def DVOA. Stopping the run has especially been an issue as their front seven clocks in at below league average in Def Rush Success Rate, EPA, DVOA, and Adjusted Line Yards. Even with their struggles on defense, be prepared to hedge with the Seahawks should the 49ers continue to underwhelm.

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Arizona Cardinals (+400) at BetMGM

After making the game winning kick against the Los Angeles Chargers in last week’s contest, the Arizona Cardinals are now 3-4 and just one game back from the Seattle Seahawks for first place in the division standings. Their offense continues to play at a competitive level since the return of Comeback Player of the Year contender Kyler Murray, ranking league average or better in Pass DVOA, EPA, and Success Rate.

Unfortunately for Arizona, they will continue to play in high variance situations as their defense ranks near dead last in DVOA, EPA, and Success Rate for the second year in a row. Defensive pressure is practically non-existent for the Cardinals as they currently rank near dead last in Pressure Rate, Adjusted Line Yards, and Adjusted Sack Rate. Until their defense can give their offense the support they need to be a well rounded division contender, then pass on their current odds to win the NFC West.

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Los Angeles Rams (+1000) at FanDuel

Like the 49ers, the Los Angeles Rams have also been dealing with an abundance of injuries since the start of the season. They kicked off their year losing their star duo of Puka Nacua and Cooper Kupp, leaving Matthew Stafford void of talent at wide receiver. His offensive line has also been decimated by injuries, playing behind backups who routinely collapse against opposing pressure.

To make matters worse for the Rams, their defense gives them little to no support as they enter week eight ranked near dead last in both Def Pass and Rush DVOA, EPA, and Success Rate. Their defensive line has been especially awful since future hall of famer Aaron Donald retired as they rank below league average in Def Adjusted Line Yards and Adjusted Sack Rate. With a lack of consistent production on either side of the ball, pass on the Rams current odds to win the division title.

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Who Will Win the NFC West - My Pick 

San Francisco 49ers (+125) at Caesars

After coming into the year as the heavy betting favorite to win the division title, as well as a contender for the Super Bowl, the 49ers are in jeopardy of missing out on the playoffs entirely as they continue to deal with devastating injuries. Especially on offense after the latest season ending injury to Brandon Aiyuk, losing a massive source of offensive production at receiver while Deebo Samuel is currently hospitalized with a sickness.

With the 49ers offense poised to regress, it’s up to their defense to help them remain competitive enough to turn their season around. Unfortunately for the 49ers, their front seven has struggled to stop the run as they currently rank just league average or worse in Def Rush DVOA, EPA, Success Rate, and Adjusted Line Yards. Their schedule also does them no favors as their quality of opponent is expected to ramp up over the next few weeks. Should you have bet on the 49ers earlier in the year, be prepared to hedge should they continue to struggle.

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NFC West History

After a two year stretch in 2020-2021, the San Francisco 49ers have reclaimed their throne at the top of the NFC West. They are in a position to add more hardware to their trophy case as they enter the year listed as the heavy favorite to win the division, adding to their 22 total division titles. 

Entering the year, the Rams were the closest threat to upset the 49ers for the NFC West title until injuries already derailed their season. As for the Seahawks, they are looking to get their 10th division title after winning it back in 2020. The Cardinals meanwhile are still in a rebuild and may be a few years away from actually contending in the division since winning it back in 2015.

Past NFC West Winners

How to Choose the Best Sportsbook for Betting on the NFC West

Acquiring as many sportsbooks as you can get is very important as it gives you the ability to line shop. Futures odds can drastically vary between sportsbooks as shown in the table below with the 49ers being listed as high as +125 at Caesars and as low as -110 at BetMGM to win the NFC West. That means you can wager a flat $100 to return more profit at +125 instead of tying in $110 to win $100 at -110 should you take their highest listed odds.

Another benefit of collecting sportsbooks is that each one has their own unique sign up bonus to help give a boost to your bankroll ahead of the start of the NFL season. BetMGM Sportsbook for example is giving new users up to $1,500 back in the form of bonus bets should they lose their first wager after creating an account with the WSN promo code WSNSPORTS.

Find more info in our detailed overview of the best NFL betting sites available today.

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How to Read NFC West Winner Odds

When making any type of wager, it’s vital to know how the listed odds work. Should you have made a wager on the 49ers to win the NFC West in the preseason at -180, then you would have had to wager $180 to profit $100 should they win the division. If you want to wager on one of the longshots like the Cardinals at +400, then a $100 wager would profit you $400 should they win the NFC West.