NFC West Odds, Predictions, Betting Picks 2025: Wrong Team Favored

• The Los Angeles Rams are currently the betting favorite to win the NFC West

• San Francisco’s Brock Purdy received a five year $265 million contract extension

• The 49ers front seven ranked 25th overall in Def Rush DVOA last season

After being ravaged by injuries last year, the San Francisco 49ers look to reclaim the division title now that they are at full health. Even with health back on their side, oddsmakers have tempered their expectations as the Los Angeles Rams enter the season as the betting favorite to win the NFC West. Should their additions pan out, then expect a close race until the very end.

NFC West Winner Odds

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NFC West Winner Predictions

Even with Cooper Kupp gone, the Los Angeles Rams are expected to sustain their high marks on offense as they replaced him with Davante Adams who is capable of replicating his loss of production. Puka Nacua also gets a full offseason to heal up after dealing with injuries throughout the year. Should their defense elevate their level of play to help turn them into a well rounded contender, then the Rams are in a great position to repeat as division winners.

Like the Rams, the Arizona Cardinals are also in desperate need of receiving support from their defense should they want to remain in contention for the division title. That side of the ball was a major weakness for them last year as the Cardinals finished the season ranked 29th in Def Pass Success Rate and 25th in Def Rush Success Rate. Should Walter Nolen and Will Johnson bolster their defense, then expect the Cardinals to join the fray for the division title.

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NFC West Winner - My Pick

San Francisco 49ers (+175) at FanDuel Sportsbook

Even though the San Francisco 49ers were decimated by injuries last season, they still managed to play at a competitive level as they finished the year ranked 10th overall in DVOA. Heading into 2025, positive regression is looming large now that health is back on their side. Especially if their front seven is able to round back into form with Robert Salah making his return as their defensive coordinator to help fix a unit that finished 25th in Def Rush DVOA.

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How to Bet on the NFC West Winner

When betting on a team to win their division, it’s important to factor in their continuity on both sides of the ball. A team who brings in a majority of their players are in a great position to succeed as it helps limit the amount of variance in their contests. Signing productive players throughout the offseason is also vital as it gives you the depth needed to deal with injuries that are sustained during the year to help remain competitive for the duration of the season.

A team’s strength of schedule and situational sports are also very important to consider as an easier schedule drastically increases a team’s chances of finishing in first in their respective division standings. Look to back a team who receives plenty of rest between primetime games and international travel as it reduces the chances of them suffering a devastating injury.

How to Read NFC West Winner Odds

Before placing a wager on a team to win the NFC West, it’s vital to know how the listed odds work. If you bet on the San Francisco 49ers to win the division at their preseason odds of +175, then a $100 wager would profit you $175 if they win the NFC West.

If you wait to see if they get off to a hot start and are listed with a minus sign in front of their odds (-125 for example), then you would need to wager $125 to profit $100. Make sure you line shop before placing a wager as the odds for the same market can vary between each sportsbook.

Where to Bet on the NFC West Winner

FanDuel Sportsbook is one of the top choices to use for the NFL as they consistently roll out amazing promotions for their users to use and are quick to update their odds throughout the season. If you have not signed up yet with FanDuel Sportsbook and are looking to get in on the action, you can claim the following offer: Bet $5, Get $200 in Bonus Bets if Your Bet Wins.

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NFC West Winner History

After dominating the NFC West early in its inception, the San Francisco 49ers and Los Angeles Rams are expected to be in a two horse race for the division title this season. Both teams reside at the top in regard to most division titles as the 49ers currently lead the NFC West with 22 championships while the Rams are in second with 15. The Seattle Seahawks meanwhile are in third with nine while the Arizona Cardinals are in last place with three.