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Bills vs Lions Week 12: Bills Hope to Stay Back on Track

Written by: Mike Lukas
Updated November 22, 2022
16 min read
  • NFL’s Turkey Day triple-header starts with the Buffalo Bills returning to Ford Field
  • The Detroit Lions are on a 3-game winning streak and HC Dan Campbell is fired up
  • Watch Bills vs Lions live on Thursday, November 24, 2022, at 12:30 PM ET on CBS

Bills vs Lions Week 12 Odds

Bills vs Lions Odds

Point Spread

Points Total

Money Line

Buffalo Bills

-9.5 (-110)  


O54 (-110)




Detroit Lions

+9.5 (-110)


U54 (-110) 




Bills vs Lions Week 12 Picks



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Bills vs Lions Predictions

Point Spread: Detroit Lions +9.5 (-110) at Caesars

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In this first of three exciting Thanksgiving Day NFL matchups, the 7-3 Buffalo Bills return to Michigan to take on the Detroit Lions who have won three in a row, this interconference battle a chance for HC Dan Campbell’s Lions to prove they are postseason worthy while the Bills hope to stay back on track as their rule of the AFC East has recently come into question.

For those new to sports betting, the Points Spread bet is an easy way to put money on your favorite team to win, with the oddsmakers giving the underdog team extra points to make it more even, and here those dogs are the Lions and their top-6 offense and 32nd ranked defense hoping to stay close with these superior Bills with their 2nd ranked offense and 13th ranked D.

It can help to research these two teams’ history against the spread, and Detroit has covered it in seven of their last eight games as home underdogs whereas Buffalo having gone 0-5 against the spread in last five games against NFC North opponents, a signal that we will take the underdog Lions and all those points and hope that their winning momentum keeps it close.

Points Total: Under 54 (-110) at DraftKings

These two offenses know how to get into the end zone and the Bills led by QB Josh Allen are the second highest scoring team in the league averaging 28.1 points per game while the Lions have the 8th highest scorers this season averaging 25 points per game, that total of 53.1 just under what the oddsmakers are projecting for this Week 12 matchup.

Each of Buffalo’s last five road games have gone under the total points line and that seems to be typical so far this season thanks in part to a slower start due to a shorter preseason, also due to good defenses like the Bills whose group is fourth best in points allowing just 17.4 per game while the Lions are last allowing 28.2 points per matchup, that 45.6 total still well under this bet.

One fun matchup to watch for in this game that might affect scoring are Bills deep threat WRs Stefon Diggs and Gabe Davis who are part of a top-3 Buffalo passing attack with 21 total receiving TDs that averages 283 air yards per game versus the Lions secondary that includes CB Jerry Jacobs and rookie FS Kerby Joseph whose 28th ranked pass defense has allowed 16 passing TDs and kept opponents to 262 receiving yards per game.

Money Line: Buffalo Bills (-420) at BetRivers



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Sports miracles do happen, especially in the parity-driven NFL, but a lot of things would have to go wrong for the Buffalo Bills to lose this game outright given that they are superior on both sides of the ball and far more used to winning than the recently hapless Lions have been, though it is a home game and those Michigan fans are loud and hip to all the right times to make big noise.

This money line bet gives the gambler a chance to put money on their favorite team to win straight up meaning no points from the oddsmakers to sweeten the deal, and in this case it will take a $420 bet on the favored Buffalo Bills to win to get back $100 plus the original bet if that comes true, a risky gamble for anyone but true believers in this team’s path to football glory.

As for you Lions fans, this money line bet would be a leap of faith given that Detroit has lost each of their last five Thursday games and are 0-9-1 straight up in their last 10 games against AFC opponents, but all that could change on any given Thursday so bet $100 on the money line for them to beat the Bills outright and win back $320 plus your bet as soon as they do.

How to Watch Bills vs Lions

  • What: Buffalo Bills vs Detroit Lions
  • Where: Ford Field in Detroit, MI
  • When: Thursday, November 24, 2022, at 12:30 PM ET
  • How: CBS
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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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