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Los Angeles Rams vs San Francisco 49ers Predictions, Odds, Picks MNF

Written by: Mike Lukas
Updated October 14, 2022
13 min read
  • In the Rams’ Week 9 loss, QB Matthew Stafford threw 2 picks and got sacked 5 times
  • The 49ers only recorded 39 total rushing yards in their Week 9 loss to the Cardinals 
  • San Francisco has lost eight of their last nine home games at Levi’s Stadium

Rams vs 49ers Odds

Odds taken from Caesars Sportsbook Click on the links below to head to the sportsbook and place your bet.

Teams Point Spread Points Total Money Line
Los Angeles Rams -4 (-110)
O49 (-113)
San Francisco 49ers +4 (-110)
U49 (-108)

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Rams Vs 49ers Week 10 Mnf

Rams vs 49ers  Pick

Take the Rams to Cower the Spread  -4 (-110)

Chances are the Los Angeles Rams are anxious to follow up their embarrassing Week 9 loss to the Tennessee Titans, 16-28, with a win here, with quarterback Matthew Stafford throwing two interceptions while getting sacked five times in that loss, and now he is listed as questionable because of his ankle, but the Rams now have deep threat receiver Odell Beckham Jr. to target.

One of the bigger problems the San Francisco 49ers had in their Week 9 loss to the injury-riddled Cardinals was the fact that they only recorded 39 total rushing yards, so if they hope to outscore these hungry Rams in this Week 10 NFC West battle, they best get rookie RB Eli Mitchell more involved as QB Jimmy Garoppolo connects with TE George Kittle.

These two NFC West rivals have met each other 143 times (including 1 postseason game), with the San Francisco 49ers winning 73 of those games and the Los Angeles Rams winning 67 of the games, plus there have been 3 ties.

Los Angeles Rams vs San Francisco 49ers Predictions 

Can Rams QB Matthew Stafford Rebound off a Poor Week 9 Outing?

Quarterback Matthew Stafford is the ideal quarterback for Rams head coach Sean McVay’s offensive system with his big arm and ability to throw on the run, but last week none of those skills seemed to matter as Stafford phoned in a stinker during a loss to Tennessee.

In that one, Stafford completed 31 passes for 294 yards and 1 touchdown with two interceptions, all while getting sacked five times (the most in any game this season) the playmaker seeming incapable of production, an odd look for such a talented quarterback.

Whatever that Week 9 fluke was, chances are it won’t happen again now that Stafford and McVay have film from it to learn from, and against the top-5 defense of the 49ers Stafford will have plenty of targets to choose including Cooper Kupp and now the recently signed Odell Beckham Jr. who left the Browns in search of more targets.

Can the 49ers’ Rushing Attack Become More Productive?

The San Francisco 49ers rushing attack features two first year players, with Elli Mitchell and Trey Sermon sharing many of the offensive carries, the team’s run game ranked 15th overall, too middling for a potentially playoff bound team like the Niners.

Mitchell is a 5’ 10” Louisiana alum who has averaged 5.4 yards per carry in the NFL, a dual threat back who has 89 carries for 469 yards and 3 touchdowns this season on top of 9 catches on 9 targets for another 73 yards of offense.

At 6’ tall and 215 pounds, rookie Trey Sermon shined at Oklahoma State and OSU, but so far for the 49ers he has had just 31 carries for 135 yards and a touchdown with two catches for another 3 yards.

Rams Key Player: (RB) Sony Michel

The Rams now have running back Sony Michel after he spent the first three of his four NFL seasons with the New England Patriots, and now the 5’ 11” 215 pound back is giving Los Angeles a run game to counter Stafford’s passing attack. 

This year Michel has had 72 carries for 271 yards and a touchdown with 8 catches for another 40 yards and a touchdown, not enough production for such a talented player as his skills are gradually worked into the Rams offensive game plan.

Week 10 against San Fran is the perfect time for Michel to shine, it could be a big night for him facing the 49ers’ 26th ranked rushing defense, his legs kept fresh by backfield counterpart Darrell Henderson, two tough-to-tackle playmakers who should make a big difference.

49ers Key Player: (WR) Brandon Aiyuk

With his excellent size and speed, the six foot two-hundred-pound San Francisco receiver Brandon Aiyuk is not easy to take down after he catches the football, the Arizona State alum now in his second NFL season. 

This year despite some shuffling around at the quarterback position, Aiyuk has had 19 catches for 230 yards and 2 touchdowns, and he is well on his way to topping his last year’s numbers when he caught 60 balls for 748 yards and 5 touchdowns during his rookie season.

In Week 10, Aiyuk will have to figure out how to get open against the Rams’ defense ranked 17th against the pass, an opportunity for him to step up and help make Jimmy G look good under center.

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How to Watch Rams vs 49ers

Rams vs 49ers Information
Teams Los Angeles Rams vs San Francisco 49ers
Location Levi’s Stadium in Santa Clara, California
Time Monday, November 15, 2021; 20:15 PM ET
How to watch ESPN


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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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