Pittsburgh Steelers vs Buffalo Bills Predictions, Odds & Picks

Steelers vs Bills Week 1 Predictions

  • After getting yanked out of the last playoffs, the Steelers are looking for a Week 1 win
  • Bills QB Josh Allen now has WR Emmanuel Sanders to target AND Stefon Diggs
  • Last time these two teams played was in 2013 when the Bills beat the Steelers, 26-15

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Steelers vs Bills Odds

Odds taken 2 Sep, 2021 from DraftKings Sportsbook

Team Point Spread Odds
Pittsburgh Steelers +6.5
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-110
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Buffalo Bills -6.5
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-110
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Steelers vs Bills Predictions and Picks

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Even though the Bills should win this game outright, it might be a close one so take the Steelers and all those points and hope that Big Ben’s elbow is up to the task.

Our Pick:

Steelers +6.5

How to Watch Steelers vs Bills

Steelers vs Bills Information
Teams Pittsburgh Steelers vs Buffalo Bills
Location Highmark Stadium in Orchard Park, NY
Time Sunday, September 12, 2021; 1:00 PM ET
How to watch CBS

After an 11-0 start to last season, the Pittsburgh Steelers ended up going 12-4 and getting yanked out of the playoffs by the Cleveland Browns, so now Big Ben Roethlisberger will use his surgically repaired throwing arm to lead this talented franchise back to postseason glory, and a Week 1 win over these Bills would certainly be a great way to start.

Now the NFL understands just how good Bills QB Josh Allen is, and when you add WR Emmanuel Sanders to the already pleasant mix of Stefon Diggs and Cole Beasley, expect this Buffalo offense to score big, often, which is what they’ll need to do to beat the Steelers here.

These two teams have faced each other 27 prior times (including 3 postseason games), with the Buffalo Bills winning 11 of those games and the Pittsburgh Steelers winning 16 games.

Can the Steelers Offense Return to Prior (Healthy) Form?

Not sure what happened to the Steelers about two-thirds through last season, but they ended the regular season going 1-5 with an offense that was ranked 25th in the league, much of it due to injury to some of their star performers.

Now the offense is back healthy, and they have some big names ready to produce, including Smith, Claypool, and Diontae Johnson with Ray-Ray McCloud and James Washington coming off the bench to add depth.

Pittsburgh’s run game must get better, ranked last in the league in 2020, so expect rookie running back Najee Harris and Benny Snell Jr. to step up and play a big role in the Steelers rushing attack against a Bills run defense ranked 17th last season.

Can the Bills Defense Neutralize Big Ben?

The key to beating the Steelers is to stop their QB Ben Roethlisberger, so it is important for the Bills defensive line to get into the backfield quickly and put the fear of sack into Big Ben’s mind at all times.

Look for defensive ends Jerry Hughes and Mario Addison to keep the Steelers’ front line busy, but only if the Bills secondary (including CB Tre’Davious White and S Micha Hyde) can keep tight coverage on all those speedy Steeler receivers.

Linebacker Tremaine Edmunds will have to play a big role on Sunday and figure out a way to add a blitz or two into the mix, already with 5.5 sacks in just three seasons.


Editor’s Picks


Steelers Key Player: (QB) Ben Roethlisberger

It’s the Steelers’ veteran QB Ben Roethlisberger’s eighteenth year in the NFL and just one full season after his elbow surgery, so whether he still has it or not under center will quickly become apparent against this Buffalo Bills much improved defense.

Fortunately for Big Ben, he has some impressive receivers to target including JuJu Smith, Chase Claypool, and TEs Eric Ebron and rookie Pat Freiermuth, all with soft hands ready to make the catch if Roethlisberger can stay standing in the pocket long enough to get the ball to them.

Problem is, the Steeler’s front line is questionable at best, currently ranked second-worst in the league, so if they expect their old QB to get the job done and stay upright while doing it, players like Chukwuma Okorafor and Zach Banner had best keep those Bill rushers away.

Bills Key Player: (WR) Emmanuel Sanders

One of the strongest offseason acquisitions for Pittsburgh is wide receiver Emmanuel Sanders, the eleven-year Pro-Bowl veteran who already has a Super Bowl ring with the Broncos, bringing his consistent hands and clever route running to Buffalo now.
So far in the NFL, Sanders has caught 662 passes for 8,619 yards and 50 touchdowns and it’s that kind of production that the Bills will be looking for as well as a defensive distraction from their other superstar receiver, Stefon Diggs.

At 5’ 11” and 186 pounds, Sanders’s size helps him win the battle for the ball, and the former SMU Mustang wants to prove in Buffalo that at 34 years old he still has plenty of gas left in the tank.

More Games to Watch on Week 1

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Mike Lukas

Expert on NFL

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]