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Best MLB Prop Bets Today: Tyler Anderson and Jose Ramirez Offer Surprising Value on Thursday

Published: May. 22, 2025, 10:00 AM ET
4 min read
Best MLB Prop Bets Today May 22

Thursday is another unusual day with a limited MLB schedule and several day games. We had to flex our creative muscles to find good value. There are some surprising prop picks, including a home run prop that’s worth a shot.

Best MLB Prop Bets Today: Phillies vs. Rockies (3:10 PM, EST)

German Marquez Over 3.5 ER

The odds Marquez is getting on this prop are almost embarrassing. Obviously, we’re not getting as much value as the last few times we’ve faded him, but we still have to take this bet. Marquez has given up at least five earned runs in six of his last seven starts, helping to give him an 8.78 ERA. Remarkably, he has a better ERA at home than he does on the road.

However, pitching at Coors Field is still challenging, and Marquez is facing a Philadelphia lineup that’s going for the four-game sweep and has already scored 25 runs over the first three games. The Phillies should have no problem scoring at least a handful of runs against Marquez.

Trea Turner Over 2.5 Hits/Runs/RBI

There is no shortage of Philadelphia hitters to target on Thursday, but we chose Turner, who tends to be in the middle of everything the Phillies do. Oddly enough, his numbers against Marquez aren’t that eye-catching, just 5 for 18 (.278) with a pair of doubles. But Turner is also 7 for 15 with four extra-base hits over the first three games of this series.

He’s hit this bet in all three games and has a total of 14 runs/hits/RBI across those three games. Turner should continue to be a catalyst for the Phillies and have another productive game.

Best MLB Prop Bets Today: Angels vs. Athletics (3:35 PM, EST)

Tyler Anderson to Record Win

Technically, the Angels are underdogs in this game, which is why we’re getting valuable odds on Anderson being the winning pitcher. However, the Halos have woken up lately, winning six in a row. They’ve averaged 7.3 runs per game during that stretch, giving their pitchers the kind of run support that’s been lacking at times. Even without a ton of run support at times, Anderson has pitched well enough to help the Angels go 7-2 in the games he’s started this season.

While he’s only been the winning pitcher twice in those seven victories, if Anderson continues to get support from the rest of the team, he can finally get a much-deserved win, especially since the Athletics have lost eight in a row and 12 of their last 14 games. Everything is trending toward Anderson and the Angels in this matchup.

Best MLB Prop Bets Today: Guardians vs. Tigers (6:40 PM, EST)

Will Brennan Under 0.5 Hits

Brennan started the season in the minors and has had a hard time getting going since being recalled 10 days ago. He has just one hit in 11 at-bats, so there is good value on him failing to get a hit on Thursday. Keep in mind that he hasn’t gotten an at-bat since Monday, so if he’s in the lineup, he’s not going to be in rhythm. The kicker is that he’s just 1 for 13 (.077) in his career against Detroit starter Jack Flaherty.

That’s all we need to know to fade Brennan.

Jose Ramirez Over 0.5 Home Runs

Ramirez is a frequent target for our prop bets, although we rarely bet on him to hit a home run. But with so few options on Thursday, we figured now is the time to take a chance. Despite Cleveland’s recent losing skid, Ramirez has been red hot lately, going 6 for 14 with a pair of doubles over his last three games. He also has three home runs in his last seven games, giving him a respectable nine homers on the season. While he’s a modest 5 for 20 (.250) in his career against Flaherty, two of those five hits have been home runs.

The bottom line is that Ramirez is swinging a good bat at the moment and has taken Flaherty deep multiple times in the past. With +550 odds, this bet is worth a shot.

tip_r

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

Expertise:
MLB
NCAAB
NFL
Online Sports Betting
Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
Email: [email protected]
Nationality: American
Education: Bachelor of Arts
Favourite Sportsbook: BetMGM Sportsbook
Favourite Casino: BetMGM Casino
Experience: 14 years
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