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No. 23 LSU vs. No. 21 Missouri Predictions, Odds & Picks

Written by: Grant Mitchell
Published October 6, 2023
10 min read

The No. 23 LSU Tigers (3-2) are aiming to bounce back from a loss when they take on the undefeated No. 21 Missouri Tigers (5-0) on the road this weekend.

LSU was one of the top favorites to make the College Football Playoff before the season started but those hopes appear to have been dashed. Can they avoid a two-game skid and take down a Mizzou team that has yet to taste defeat? Here, we will break down the impending matchup.

No. 23 LSU vs. No. 21 Missouri Odds

TeamSpreadMoneylinePoints Total
No. 23 LSU-5.5 (-110)-238Over 64.5 (-110)
No. 21 Missouri+5.5 (-110)+195Under 64.5 (-110)

Odds from DraftKings SportsbookGet $200 in bonus bets when you wager just $5 using our exclusive link.

LSU tigers vs Missouri Tigers Predictions

No. 23 LSU vs. No. 21 Missouri Betting Preview

LSU QB Jayden Daniels has been the star of the first five weeks and is hanging around the top 10 in Heisman odds. He’s thrown for 1,710 yards, 16 touchdowns, and two interceptions, and run for another 292 yards and three scores. He also ranks ninth nationally in QBR (86.1).

The Tigers’ defense has been the letdown and the reason they are only one game over .500. They surrendered 45 points to Florida State in the opener and just gave up 55 points on the road to Ole Miss in a six-point loss. They allowed 389 yards passing and 317 yards rushing and were dominated on the interior.

LSU now has to go against a Missouri team that was expected to do well but is still outperforming what many expected. They’ve only played one ranked team, No. 15 Kansas State, in Week 3, and they won that game 30-27.

Brady Cook has completed nearly 75% of his passes and averaged just under 300 yards per game. He also has 11 touchdowns and no interceptions, while the running game averages a modest 4.0 yards per carry.

Despite both competing in the SEC, these teams have only faced off three times. Missouri holds the series advantage 2-1 and beat them in 2020 45-41.

No. 23 LSU vs. No. 21 Missouri Picks & Predictions

LSU -5.5 (-110)

The Tigers have played well and deserve their respect, but their offense is not as explosive as LSU’s, and they were taken advantage of by both Kansas State and an average Memphis team.

Mizzou’s secondary is the weakest unit on the defense, which is a nightmare going against Daniels and the LSU receiving corps. It’s also important to remember that the visitors just scored 49 points on the road against Ole Miss and are still running hot offensively.

It might be too late for LSU to save its postseason aspirations, but they are still an objectively better team than Missouri and do not deserve to be discarded because they lost to two strong opponents.

Over 64.5 (-110)

The total has risen since the lines opened earlier in the week and will likely continue to do so until kick-off. While it’s not always sound advice to back the public, we’re riding with the masses here.

Both teams have trended over this season and are defined by their offenses. They scored a combined 87 points last week and are weakest on defense, which are both reasons to lean into the over.

Yet another factor supporting the over is that the quarterbacks have done an excellent job taking care of the football and have a combined two interceptions between them.

No. 23 LSU vs. No. 21 Missouri Betting Promos

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How To Watch No. 23 LSU vs. No. 21 Missouri

  • Where: Memorial Stadium/Faurot Field in Columbia, MO
  • When: Saturday, Oct. 7, 11:00 a.m./12:00 p.m. CT/ET
  • TV: ESPN

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Grant Mitchell

538 Articles

Grant is a sports and sports betting journalist who prides himself on delivering breaking news and insightful analyses of the industry. Grant graduated from Virginia Tech in 2021 and is feverishly pursuing his ambitions in the sports betting field.

In his free time, Grant can be found passionately watching sports, doing a workout, or searching for adventure with his friends.

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