When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

San Francisco 49ers vs Dallas Cowboys Predictions, Odds, Picks

Written by: Mike Lukas
Updated October 14, 2022
13 min read
  • The Steelers are the AFC’s 7th playoff seed and a huge underdog to these Chiefs
  • The KC Chiefs led by QB Patrick Mahomes have won nine of their last ten games 
  • Kansas City has been the first team to score in all ten of their last games

Steelers vs Chiefs Odds

49ers Vs Cowboys January 16

Play Fantasy Sports Here!

🔥 Claimed by 199 people this week!



Get a No Sweat First Bet up to $1,000

21+ | T&Cs apply

The San Francisco 49ers’ Week 18 overtime win over the Rams to clinch their way into an NFC Wildcard spot must have felt extra sweet to QB Jimmy Garoppolo (finger) who said he was in pain every time he threw the ball, while WR Deebo Samuel was incredible, and their top-3 defense led by Nick Bosa and Fred Warner now facing one of the tougher offenses in the NFC.

The Dallas Cowboys have won five of their final six matchups in the regular season to move to 12-5 and win the NFC East, their playmaking QB Dak Prescott now looking healthy and firing on all cylinders to his superior targets – Amari Cooper, CeeDee Lamb, and TE Dalton Schultz – while RB Zeke Elliott seems mostly healthy and still a major threat from out of the backfield.

These two NFC rivals have played each other 37 prior times (including 7 postseason games), with the Dallas Cowboys winning 19 of those games and the San Francisco 49ers winning 17 of the games, plus there has been a tie.

San Francisco 49ers vs Dallas Cowboys Predictions

Can Niners QB Jimmy Garoppolo (finger) Play Injured and Win?

San Francisco starting QB Jimmy Garoppolo hurt a finger in his throwing hand in the Week 16 game against the Titans, and now he has said that every time he throws the ball it feels like his hand is being torn off, not a good feeling when you are attempting so many passes.

Jimmy G’s injury could explain the two interceptions he through in the team’s desperation win over the Rams in Week 18, a potential weak spot that has the chance to go south quickly if he becomes unable to grip the ball properly after a week of practice.

The Niners have a good backup QB, Trey Lance, though the fact that he is a rookie works against him succeeding in the postseason, but HC Kyle Shanahan has proven he does not fear a challenge and chances are the team will get some help from rookie RB Elijah Mitchell.

Can the Cowboys Continue to Play Complimentary Football?

It’s an age old concept, playing complementary football, meaning having all three phases of your team firing smoothly and effectively, with the offense on the field and scoring often because the defense has shut down the opponent quickly and the special teams have delivered the ball.

This season, the Cowboys seemed to struggle with all three parts of their roster working well in conjunction, a big picture problem that HC Mike McCarthy has seemed to figure out since his team has been winning games consistently, as in five of the last six in the regular season.

Now it will be up to QB Dak Prescott and RB Zeke Elliott to charge up the offense, for LB Micah Parsons and CB Trevon Diggs to get the defense going, and for placekicker Greg Zuerlein’s crew to keep the transitions smooth if this Cowboys team expects to go far in these playoffs.

49ers Key Player: (WR) Deebo Samuel

One of the incredible playmakers of many on this San Francisco 49ers roster is dual-threat receiver Deebo Samuel, a 6’ 215-pound wrecking ball who started out as an NFL receiver but who has morphed into an effective running back, as well, a huge part now of this Niners offense.

So far in the 2021 regular season, Samuel has scored at least one touchdown in seven of his last eight-game appearances, his ability to shift gears and directions at will has left defenders stumbling, so far with 136 total touches for 1,770 yards from scrimmage and 14 touchdowns.

One thing that San Francisco OC Mike McDaniel can count on is for Samuel to want the ball and to deliver said ball to the end zone, this three-year pro now with 10 total touchdowns in his career, also his 18.2 yards per catch this season are leading the league.

Cowboys Key Player: (QB) Dak Prescott

After an up and down start to his season, a miraculously healthy Cowboys QB Dak Prescott is now putting on an offensive show in Dallas that has his Cowboys as the winners of the NFC East and the fourth NFC seed in the postseason, his number one offense ready for blood.

Prescott worked hard to get his body healthy again after a season-ending leg injury took him down in 2020, an impressive comeback that comes with some equally inspiring numbers, this year having completed 410 passes for 4,449 yards and 37 touchdowns with 10 interceptions.

How far the Cowboys go in the postseason will most likely depend on how well Prescott plays and connects with his talented group of targets including WRs Amari Cooper and CeeDee Lamb and TEs Blake Jarwin and Dalton Schultz, and RB Zeke Elliott is also a dependable receiver.

Find the best betting bonuses, right here!

Play Fantasy Sports Here!

Logo #1



Bet $5, Get $150 in Bonus Bets

21+ | Terms and conditions apply

Logo #2



$500 Bonus Bet

21+ | VA only | Gambling problem? Call 1-800-532-3500

How to Watch 49ers vs Cowboys

49ers vs Cowboys Information
What San Francisco 49ers vs Dallas Cowboys
Where AT&T Stadium in Arlington, Texas
When Sunday, January 16, 2022; 4:30 PM ET
How to watch CBS

Get a No Sweat First Bet up to $1,000

21+ | T&Cs apply

Claim Now
Image for Mike Lukas


Mike Lukas

1205 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

More info on Mike Lukas
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks

© Rebel Penguin ApS 2024 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.