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Eagles vs Cardinals Week 5: Arizona’s Defensive Front Must Keep Under Pressure

Written by: Mike Lukas
Updated October 14, 2022
17 min read
  • The Philadelphia Eagles are starting out 4-0 for the first time since the 2004 season
  • Last week, the Arizona Cardinals scored 23 second-half points for their second win
  • Watch Eagles vs Cardinals live on Sunday, October 9, 2022, at 4:25 PM ET on FOX

Eagles vs Cardinals Week 5 Odds

Odds taken from Caesars Sportsbook. Click on the links below to head to the sportsbook and place your bet.

Eagles vs Cardinals Odds Point Spread Points Total Money Line
Philadelphia Eagles -6.5 (-110)
O49 (-110)




Arizona Cardinals +6.5 (-110)


U49 (-110)




Eagles vs Cardinals Week 5 Picks

Point Spread: Arizona Cardinals +6.5 (-110) at Caesars

Over/Under: Over 49 (-110) at DraftKings

Money Line: Philadelphia Eagles (-110) at BetMGM

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Eagles Vs Cardinals Predictions Hurts

 Arizona Cardinals +6.5 (-110) at Caesars

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The Philadelphia Eagles are starting their season out 4-0 for the first time since 2004 and their 2nd ranked offense is led by mobile and hard-throwing QB named Jalen Hurts who is developing a scary connection with deep threat WR A.J. Brown, both facing a Cardinals pass defense ranked just 24th in the league right now.

Arizona’s offense is ranked 15th in passing and rushing led by their mobile franchise QB Kyler Murray who this season has completed over 65 percent of his passes for almost 1,000 yards and 5 TDs with 2 INTS along with 24 carries for 91 yards and 2 more TDs, ranked 15th at his position and a player that Philly DEs Fletcher Cox and Josh Sweat must contain in the pocket.

Compare that to the Eagles’ Hurts who is 5th among NFL QBs completing 67 percent of his passes for 1,120 yards and 4 passing TDs and 2 INTS plus 53 carries for 205 yards and4  more TDs, a tough weapon that Arizona’s defensive front must keep under pressure, that group so far struggling with QB takedowns posting only 4 total sacks this season, tied for last in the league.

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Eagles vs Cardinals Over 49 (-110) at DraftKings

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All teams have up and down weeks when it comes to scoring but the Philadelphia Eagles have found the end zone quite often this season so far averaging almost 29 points per game, fourth best overall, whereas the Arizona Cardinals have scored 22 points per game, that total of 51 a few points over what the odds makers expect which is 49.

From a defensive angle, these teams can be measured by how many points on average they allow, and the Eagles this season have let opponents score 17.8 points per game while the Cardinals defense has let the teams they have played score 25.8 points each time, that total of 43.6 over five points under what this bet allows, another way to think logically about this one.

Of course, injuries could play into each team’s ability to score points here, with the Cardinals banged up having WR A.J. Green (knee) and OG Justin Pugh (elbow) listed as questionable to play on Sunday, while the Eagles have seven players who might not be able to go either, including K Jake Elliott (ankle), CB Avonte Maddox (shoulder), and RB Boston Scott (ribs).

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Philadelphia Eagles (-225) at BetMGM

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This game should be close which is why we suggest taking the Arizona Cardinals and the points to cover the spread, however for the money line bet it makes more sense to bet on the undefeated Philadelphia Eagles, the oddsmakers favoring them and paying bettors $100 on any $225 bet on this NFC cross-divisional matchup.

The other bet here is to use $100 out of your betting kitty and bet on the underdog Cardinals to end the Eagles’ win streak outright, and if that happened you would win back your original wager plus $265, a great deal if you are an Arizona fan who is certain that Murray’s bunch is on the rise and can take on this Philly team that ranks better than them on both sides of the ball.

If the Cardinals expect to play in the postseason, a divisional win here would help them in the NFC West as well as in the NFC in general since the Wildcard teams depend on all sorts of tiebreakers including divisional and conference win totals, something that the Eagles HC Nick Sirianni and Cardinals HC Kliff Kingsbury are no doubt aware of as they game plan a win here.

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How to Watch Eagles vs Cardinals

  • What: Philadelphia Eagles vs Arizona Cardinals
  • Where: State Farm Stadium in Glendale, AZ
  • When: Sunday, October 9, 2022; 4:25 PM ET
  • How: FOX
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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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