Falcons vs. Bills Same Game Parlay Picks: Bills Hope to Bounce Back Against Well-Rested Falcons

• The Bills have allowed the fourth-most rushing yards in the NFL this season

• Buffalo has scored at least 30 points in four of five games

• James Cook is tied for the second-most rushing touchdowns with five

Week 6 gives NFL fans yet another Monday night doubleheader. The early game gives us an interesting matchup between the Buffalo Bills and the Atlanta Falcons. These teams rarely play one another, playing just once since 2017, but they’ll cross paths at a critical juncture for both sides.

The Bills are coming off their first loss of the season, a defeat that stings even more coming at home against the Patriots. Buffalo is just one game ahead of New England in the AFC East and will play five of its next seven games on the road. Meanwhile, the Falcons had a bye last week to enjoy their win over the Commanders. But with the 4-1 Buccaneers starting to pull away in the NFC South, Atlanta needs to keep up its momentum and stay close to Tampa.

The good news for the Bills is that despite last week’s loss, they are still favorites to win the AFC Championship and reach the Super Bowl. Likewise, Josh Allen remains the MVP frontrunner. Meanwhile, the Falcons are very much contenders in the NFC South, even if the Buccaneers are the current favorites. 

Since Monday’s game is a big deal for both teams, we thought it would be fun to put together a three-leg parlay. The odds for our parlay are from FanDuel Sportsbook, which is giving new users a chance to receive $300 in bonus bets if they sign up and win their first bet. As for our parlay, the current odds at FanDuel are a lucrative +316.

Best Falcons vs. Bills Same Game Parlay Picks

Falcons +3.5 (-105) at FanDuel Sportsbook

Last week’s loss to the Patriots aside, winning hasn’t been a huge issue for the Bills this year. But covering the spread is another issue. They’ve struggled to put away weak teams like the Dolphins and Saints, failing to cover the spread in those wins. That makes us hesitant to believe Buffalo can cover Monday’s spread, especially if you play with the line in a parlay to make the spread more than a touchdown.

Buffalo’s defense is a lingering concern, especially against Bijan Robinson and Atlanta’s running game. The Bills have allowed the fourth-most rushing yards in the NFL this year, which should enable the Falcons to lean on him and keep the game close. It’s also worth mentioning that this is only Buffalo’s second road game of the season. After some issues at home in recent weeks, the Bills aren’t likely to be dominant on the road.

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Over 49.5 (-118) at FanDuel Sportsbook

If you want to tease this number down just a little in a parlay, that’s fine, but the expected over/under value of 49.5 points works too because this is likely to be a high-scoring affair. Granted, the Falcons are just 1-3 O/U this year. But their two home games have been their highest-scoring games, which makes sense in a weatherless, offense-friendly environment.

Meanwhile, the Bills are 3-2 O/U this season, with all five of their games reaching at least 40 points and three of them reaching 50 points. The Bills by themselves have scored at least 30 points in four of their five games. That trend is likely to continue, and with the Buffalo defense conceding 22.6 points per game, it’s a safe bet that this game reaches at least 50 total points.

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James Cook Anytime Touchdown (-155) at FanDuel Sportsbook 

Cook was held out of the end zone last week, but that’s not a trend that’s likely to continue. He scored at least one touchdown in each of Buffalo’s first four games of the season. Cook enters Week 6 with five touchdowns in 2025, making him the safest pick to score on Monday, especially if the Bills utilize him more in the passing game.

It’s worth mentioning that the Falcons have been stingy defensively, allowing just two rushing touchdowns all season. But it’s also safe to say that they haven’t faced an offense as dynamic and balanced as the Buffalo offense. The Bills have nine passing and nine rushing touchdowns this season. When they get close to the end zone, they trust Cook to get over the line, which is why he’s worth trusting in a parlay.

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More NFL Week 6 Stories

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• Bears vs. Commanders Same Game Parlay Picks

• Bears vs. Commanders Prop Bets