NFL Odds Week 6: Odds and Betting Lines for Every Game

• The Bills and Eagles both lost last week to snap their undefeated records

• The Ravens are now 1-4 heading into a game against the Rams

• The Lions are back in first place in the NFC North with a 4-1 record

This week will mark a third of the way through the NFL season and there are plenty of exciting matchups on the board. The Bills and Eagles will look to respond following a loss on Sunday, while the Ravens are just trying to stay afloat in the AFC North. 

The race for the Super Bowl continues this week. Here, we will give a short analysis of each game on the slate with our pick. 

NFL Odds for Week 6

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Eagles vs. Giants Odds, Thursday, 8:20 PM EST

• Eagles: Spread -7.0 (-115) | Moneyline -425

• Giants: Spread +7.0 (-105) | Moneyline +325

• Total: Over/Under 40.5 (-110/-110)

The New York Giants will host the Philadelphia Eagles on Thursday in an NFC East battle. The Eagles blew a 17-0 lead last Sunday, and they should be ready to do damage in this contest. 

The Eagles have an issue putting teams away, and this showed against the Broncos last week. They should have learned their lesson, and apply it on Thursday.  

The Giants don’t stand a chance with their rookie quarterback Jaxson Dart. Look for the Eagles to get back on the winning train and cover the spread. 

Broncos vs. Jets Odds, Sunday, 9:30 AM EST

• Broncos: Spread -7.0 (-115) | Moneyline -380

• Jets: Spread +7.0 (-105) | Moneyline +300

• Total: Over/Under 43.5 (-110/-110)

The NFL will play in London for the second consecutive week when the Broncos face the Jets. Denver is a touchdown favorite, and we’re riding this side of the line.

The Broncos made plays on offense in a fourth-quarter comeback against the Eagles last Sunday. If they can get Courtland Sutton involved early, the Broncos should cruise to a win. 

Sutton had 99 yards last week against the Eagles, which was his second-best performance of the season. 

Browns vs. Steelers Odds, Sunday, 1:00 PM EST

• Browns: Spread +5.5 (-110) | Moneyline +220

• Steelers: Spread -5.5 (-110) | Moneyline -270

• Total: Over/Under 38.0 (-110/-110)

Dillon Gabriel made his NFL debut for the Browns last week, and nearly led them to a win over the Vikings. Gabriel threw for two touchdowns and didn’t turn the ball over, which put his team in a position to be victorious. 

However, Minnesota had a game-winning drive, which ended Cleveland’s winning chances. The Browns will improve with Gabriel, but Pittsburgh is a better team and they’re coming off a bye week. 

The Steelers' extra preparation time will make the difference on Sunday. 

Chargers vs. Dolphins Odds, Sunday, 1:00 PM EST

• Chargers: Spread -4.0 (-110) | Moneyline -220

• Dolphins: Spread +4.0 (-110) | Moneyline +180

• Total: Over/Under 43.5 (-110/-110)

The Los Angeles Chargers were one of the AFC Championship favorites at the beginning of the season. This expectation had faded after their recent two losses. 

The team only scored 10 points last week against the Commanders, and Justin Herbert was a big reason for the failure. 

The Dolphins are a bad team, so Los Angeles has a chance to respond this week. Three straight losses for Los Angeles could be deadly, so we’ll side with Jim Harbaugh’s squad in Week 6.

Patriots vs. Saints Odds, Sunday, 1:00 PM EST

• Patriots: Spread -3.5 (-105) | Moneyline -190

• Saints: Spread +3.5 (-115) | Moneyline +160

• Total: Over/Under 45.5 (-110/-110)

The New England Patriots are coming off one of the best wins in years for the franchise. New England beat Buffalo as an 8.5-point underdog on the road.

Drake Maye looked like one of the best young quarterbacks in the NFL, completing over 70% of his passes. Now, New England travels to New Orleans to face the Saints who are coming off a win over the Giants.

Mike Vrabel’s team should build off their win against the Bills, and beat an inferior opponent in New Orleans. Look for Maye to continue establishing himself as a legitimate starting quarterback in the NFL.

Seahawks vs. Jaguars Odds, Sunday, 1:00 PM EST

• Seahawks: Spread +1.0 (-115) | Moneyline -105

• Jaguars: Spread -1.0 (-105) | Moneyline -115

• Total: Over/Under 47.5 (-110/-110)

The Seattle Seahawks are coming off a devastating loss to the Buccaneers. Sam Darnold played excellent against Tampa Bay, but a late turnover cost his team the game. 

Jacksonville just beat Kansas City, so they’ll be very motivated to build off their win from last week. Seattle has been excellent on the road, and they’re a better overall team than Jacksonville. 

Jaxon Smith-Njigba is one of the best receivers in the NFL, and this will make the difference on Sunday. 

Cardinals vs. Colts Odds, Sunday, 1:00 PM EST

• Cardinals: Spread +7.0 (-110) | Moneyline +275

• Colts: Spread -7.0 (-110) | Moneyline -350

• Total: Over/Under 47.0 (-110/-110)

The Cardinals are a careless football team. Arizona had plenty of chances to beat Tennessee in Week 5, and they coughed the game up because of mental mistakes. 

Arizona doesn’t have a great team, and they haven’t found any rhythm on offense or defense. Last week’s loss could be the nail in the coffin for Arizona, especially when they’re outmatched against the Colts. 

Indianapolis is a 6.5-point favorite over Arizona, and this isn’t enough points to side with the Cardinals. The Daniel Jones show will continue on Sunday in dominant fashion. 

Rams vs. Ravens Odds, Sunday, 1:00 PM EST

• Rams: Spread -7.5 (-105) | Moneyline -400

• Ravens: Spread +7.5 (-115) | Moneyline +320

• Total: Over/Under 44.5 (-110/-110)

The bye week can’t come soon enough for the Baltimore Ravens. The Ravens had the most injuries in the NFL, and they have no chance of winning without NFL MVP quarterback Lamar Jackson. 

Jackson is one of the best players in the NFL, but it looks like he’ll miss Week 6. The Ravens’ defense has been terrible defending the pass, which isn’t great against the Rams, who can throw the ball all over the field. 

Puka Nacua will have a huge game and lead Los Angeles to a dominant win because of Baltimore’s injuries. 

Cowboys vs. Panthers Odds, Sunday, 1:00 PM EST

• Cowboys: Spread -3.0 (-110) | Moneyline -170

• Panthers: Spread +3.0 (-110) | Moneyline +145

• Total: Over/Under 49.5 (-110/-110)

The Carolina Panthers are coming off a win over the Dolphins, but they’re still one of the worst teams in the league. Bryce Young is very inconsistent, and this isn’t great for a starting quarterback. 

The Cowboys' defense has been shaky all season, but they can score, which is clear by the high total in this game. Dallas is a 3.5-point favorite, and this line should continue to get larger because they’re superior in all aspects. 

George Pickens will continue his domination, which should put the Cowboys in a position to win and cover on Sunday. 

Titans vs. Raiders Odds, Sunday, 4:05 PM EST

• Titans: Spread +4.5 (-110) | Moneyline +195

• Raiders: Spread -4.5 (-110) | Moneyline -240

• Total: Over/Under 41.5 (-110/-110)

The Raiders were embarrassed last week against the Colts. When a team gets dominated, they tend to respond the following week. 

Las Vegas should play better in Week 6 because they’re hungry to bounce back and they’re facing an inferior team in the Tennessee Titans. The Titans won their first game last week, but Arizona gave them the win. 

Rookie quarterback Cam Ward is starting to play with more confidence, but it won’t be enough to beat the Raiders with Maxx Crosby in his face all game. 

49ers vs. Buccaneers Odds, Sunday, 4:25 PM EST

• 49ers: Spread +3.0 (-115) | Moneyline +125

• Buccaneers: Spread -3.0 (-105) | Moneyline -150

• Total: Over/Under 47.5 (-110/-110)

The Buccaneers are running away with the NFC South title after five games. Tampa Bay is 4-1 and coming off a great win over the Seahawks. 

Baker Mayfield was outstanding in the win, throwing for 379 yards and two touchdowns. Emeka Egbuka had 163 yards through the air, and he is now 4th in the NFL in receiving yards. 

The 49ers are very beat up, and they shouldn’t be able to hang with Tampa Bay on the road in this game. The field goal spread isn’t enough to side with the 49ers. 

Bengals vs. Packers Odds, Sunday, 4:25 PM EST

• Bengals: Spread +14.0 (-110) | Moneyline +650

• Packers: Spread -14.0 (-110) | Moneyline -1000

• Total: Over/Under 44.5 (-110/-110)

The Cincinnati Bengals can’t survive without Joe Burrow. Their defense can only do so much to keep them in game when the offense can’t generate any points. 

Jake Browning is known for being a reliable backup, but he hasn’t been close to this status in 2025. The quarterback has thrown eight interceptions in four games, but this is the cost of trying to score points with a bad quarterback. 

The Packers are still one of the NFC front runners, but this spread is massive, so it’s worth trusting the Bengals, as scary as that sounds.

Lions vs. Chiefs Odds, Sunday, 8:20 PM EST

• Lions: Spread +2.0 (-110) | Moneyline +115

• Chiefs: Spread -2.0 (-110) | Moneyline -135

• Total: Over/Under 53.0 (-110/-110)

The Chiefs are back in prime time again after losing to the Jaguars in Week 5 on Monday. The Chiefs' short week doesn’t help them here because they need rest. 

Kansas City has been sloppy all season, and they’re now 2-3. The Lions are an underdog on the road, but they’re a much better team than Kansas City. 

Jared Goff is playing great, while the Chiefs have no offensive consistency. It’s hard to win at Arrowhead Stadium, but the Lions are better all over the field. 

Bills vs. Falcons Odds, Monday, 7:15 PM EST

• Bills: Spread -4.5 (-110) | Moneyline -220

• Falcons: Spread +4.5 (-110) | Moneyline +180

• Total: Over/Under 49.5 (-110/-110)

The Atlanta Falcons are 2-2 and coming off a bye week, so they’ve had plenty of time to prepare for Josh Allen and the Bills. However, this is a bad spot for the Falcons because the Bills just played terrible against the Patriots, and they’re a championship caliber team that doesn’t play bad two weeks in a row. 

The Falcons need to establish a run game with Bijan Robinson early on Sunday, but even if they do, Buffalo should still overpower their opponent. 

Allen will look like the MVP quarterback he is and lead the Bills to a big win on Monday. 

Bears vs. Commanders Odds, Monday, 8:15 PM EST

• Bears: Spread +4.5 (-110) | Moneyline +185

• Commanders: Spread -4.5 (-110) | Moneyline -225

• Total: Over/Under 49.5 (-110/-110)

The Chicago Bears are coming off a bye week, which came at a bad time. The team put together two consecutive wins, and they need to ride the momentum. 

The bye week could cause them to go back to their bad habits from the first two games. The Commanders have Jayden Daniels back, and he led Washington to a win over Los Angeles last week. 

Washington is superior when Daniels is healthy. Even though the Bears have extra preparation time, it won’t make a difference against a dynamic quarterback like Daniels. 

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