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NFL Week 10 Parlay: Best NFL Parlays for Week 10

Written by: Michael Sicoli
Published November 9, 2023
8 min read

The parlay fell one leg short yet again, and that’s because Matthew Stafford ended up sitting out for the Rams after being hopeful earlier in the week. Perhaps this column should switch to four legs.

Still, this parlay article should provide plenty of options for your bets, with far more picks hitting than missing. Let’s dive into Week 10 and aim for a perfect 5/5!

The Parlay

Odds from DraftKings Sportsbook. Head to DraftKings using our link, sign up and claim $200 in bonus bets

PickOddsPayout (Increasing with each leg, top to bottom)
SF @ JAX: ALT 49ers -2.5-134
$10 to win $17.46
DET @ LAC: Amon-Ra St. Brown Anytime TD-105
$10 to win $34.09
NYG @ DAL: ALT Giants UNDER 14.5 points-245
$10 to win $48.00
WAS @ SEA: ALT OVER 42.5-171
$10 to win $76.08
DEN @ BUF: UNDER 47 points-112
$10 to win $144.01
Best NFL Parlays for Week 10

Leg #1 - SF @ JAX: ALT 49ers -2.5 (-134)

This buys half a point to get the spread under a field goal.

The 49ers have struggled over the last month, but a much-needed Week 9 bye gives them a chance to get back on track. They not only should return Deebo Samuel (shoulder) and Dre Greenlaw (groin) to the lineup, but San Francisco also added Chase Young to its defensive line after trading for him at the deadline.

Meanwhile, Jacksonville hasn’t faced an opponent of the same caliber as the 49ers since Week 2 against the Chiefs, when the Jaguars lost 19-7. A healthy 49ers team can handle the AFC South leaders with a small spread to cover.

Leg #2 - DET @ LAC: Amon-Ra St. Brown Anytime TD  (-110)

It’s tough to pick a winner in this one between two high-powered teams. So instead, we’ll lean on the Sun God in Amon-Ra St. Brown to find the end zone.

St. Brown only has three touchdowns this season. Still, he’s a good bet this week against a Chargers defense that has been solid on the ground, but horrific through the air. The Chargers have allowed nine touchdowns to wide receivers in eight games this season, easily sitting below the league average defensively.

St. Brown hasn’t had the easiest schedule this year, but he has boomed in the few top-10 matchups he’s had. The Chargers are arguably the best yet, and with how well Justin Herbert is playing, the Lions will pass the ball quite a lot to take advantage of the matchup.

Leg #3 -  NYG @ DAL: UNDER 14.5 points for NYG (-245)

Any chance you get to bet against Tommy DeVito, you should take it. The Giants would struggle to move the ball on a good day against the Cowboys, and an offense with a third-string QB and no Darren Waller is bound to struggle.

The Giants have scored more than 14 points just twice all year. They haven’t done so since Week 5, and Dallas allows just 18.5 PPG, sixth-best in the league.

Even if the Giants manage one score, it’s incredibly unlikely to see them push over 14 points on the road in Dallas. The Cowboys also suffered a brutal divisional loss to Philadelphia in Week 9, making this matchup a perfect bounce-back situation.

Leg #4 -  WAS @ SEA: ALT OVER 42.5 (-171)

This Washington defense has been gutted of most of its talent, with a few pieces like Daron Payne, Kamren Curl, and Jonathan Allen remaining. Seattle should be able to get back on track in Week 10.

The Seahawks were embarrassed against Cincinnati last week, but they have a good chance to rebound against a Washington team that sits 30th in PPG allowed (27.2). Seattle has scored 20+ points in five of its eight games and has a must-win game against Washington if the Seahawks hope to take the NFC West.

Kenneth Walker should be healthier, and Jaxon Smith-Njigba is starting to emerge with 210 of his 272 receiving yards coming after the team’s Week 5 bye. Meanwhile, Washington has scored 20+ points in seven of the team’s nine games this season.

Buying a couple points and betting on both offenses to score is a solid bet to make. 

Leg #5 -  Denver @ BUF: UNDER 47 (-112)

The Denver Broncos' defense was fairly maligned earlier this season, especially after allowing 70 points to Miami in Week 3. However, Denver has allowed just 15 PPG over its last three games.

That includes two games against Kansas City. The Chiefs have scored less than 20 points in just three games this year, with two of those games coming against Denver. A floundering Bills offense that is struggling to find a rhythm may not break that streak, at least not to the tune of a surprisingly high over/under.

Don’t forget Buffalo’s defense, as well. The Bills have allowed just 17.8 PPG this season, fifth-best in the NFL. 

While they’ve been more susceptible in recent weeks, the Bills are far better at home than they are on the road. Buffalo allows just 14.3 PPG at home compared to 20.6 on the road.

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Michael Sicoli

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Michael Sicoli has been writing about fantasy football and betting within the NFL space since 2020. He works as a writer and content creator with ClubFantasyFFL and runs an NFL defensive (IDP) newsletter with The IDP Guys. A graduate from Quinnipiac University, Michael is a long-time NFL fan with a love for soccer and the NBA.

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