When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

Image for Mike Lukas Mike Lukas - Updated October 14, 2022

Seattle Seahawks vs Indianapolis Colts Predictions, Odds & Picks

Seahawks Colts Week 1 Predictions
  • Seahawks QB Russell Wilson is now working with a new OC, Shane Waldron
  • Colts QB Carson Wentz is fresh off a recent foot injury and subsequent surgery
  • These two haven’t played since 2017 when the Seahawks beat the Colts, 46-18

Play Fantasy Football, Here!

Seahawks vs Colts Odds

Odds taken 3 Sep, 2021 from DraftKings Sportsbook

Team Point Spread Odds
Seattle Seahawks -2.5
Indianapolis Colts +2.5

Here is your chance to win a $600! Sign-up to our  NFL Pick ’em Contest!

Seahawks vs Colts Predictions and Picks

Might want to take the well-oiled Seahawks machine in Week 1 since, even if Wentz can play, it might take him a few weeks to bang the rust off his surgically repaired foot.

Our Pick:

Seahawks -2.5

Play Fantasy Football, Here!

The Seattle Seahawks have a healthy QB in Russell Wilson who is now working with a new OC Shane Waldron who will make it his job to game plan around his speedy WRs DK Metcalf and Tyler Lockett so long as DC Ken Norton’s upgraded defense can keep these Colts off the field.

Indianapolis Colts QB Carson Wentz is fresh off a recent foot injury and subsequent surgery, but he says he will be ready to go in Week 1 (expect a bit of rust, maybe?), while defensively, rookie end Kwity Paye will be trying to sack Wilson with the help of veteran DT DeForest Buckner in front of a hometown crowd.

These two cross-conference enemies have met each other 12 prior times, with the Indianapolis Colts winning 7 of those games and the Seattle Seahawks winning 5 of the games.

Can the Seahawks Offense Return After Struggling in 2020?

The Seattle Seahawks front office decided to change offensive coordinators this offseason after ranking a dismal 17th in the league last year under OC Brian Schottenheimer, and now the team’s offense will be run by former Rams passing game coordinator Shane Waldron.

The hope is that Waldron can better utilize the playmakers he has at his disposal now, such as wide receivers DK Metcalf and Tyler Lockett and tight end Gerald Everett plus running back Chris Carson who gives the offense a powerful backfield twist.

Despite their relative lack of offensive production last year the Seahawks were still able to put almost 29 points per game on the board, so imagine what Wilson, last season’s 9th most productive QB, can score once an upgraded game plan is put in place.

Can the Colts Turn All That Roster Talent into Wins?

Ever since the Colts franchise QB Andrew Luck retired before the 2019 season, the Indianapolis Colts have been searching for a replacement under center, trying anyone from Jacoby Brissett to veteran Philip Rivers in that spot with questionable results.

Now the team is counting on oft-injured veteran Carson Wentz to hurl footballs for them and already he is having to start the new season on the mend, now at the end of rehabbing his surgically repaired foot.

With a top-10 defense last season and talent on offense like wide receivers TY Hilton and Michael Pittman Jr. plus tight end Jack Doyle and running back Jonathan Taylor, this Colts team needs a leader like a healthy Wentz to put it all together on the field and turn that into wins.

Editor’s Picks

Seahawks Key Player: (WR) DK Metcalf

This will be Seahawks receiver DK Metcalf’s third NFL season and so far he has not disappointed, the perfectly sculpted Mississippi alum with the size and the speed to make a huge impact on the field.

Last year Metcalf had his best season yet, posting 83 catches on 129 targets for over 1300 yards and 10 touchdowns proving to be a speedy receiver who tends to get open deep and who can earn extra yards after the catch.

QB Russell Wilson and Metcalf are developing a fantastic connection so expect this season to top even the last, especially if Seattle’s 12th ranked run game can continue to offer a decent counterbalance to the absolute passing threat this combo poses.

Colts Key Player: (RB) Jonathan Taylor

Last season as a rookie, Colts running back Jonathan Taylor made quite an impression, running the ball 232 times for 1,169 yards and 11 touchdowns while catching 36 passes for another 300 yards and a touchdown.

That type of production from a rookie is rare, so the Colts know that what they have in Taylor is special, and now that the entire league understands what a powerful runner this Wisconsin alum is expect them all to game plan a way to stop him.

Whether Taylor and offensive coordinator Marcus Brady can top that rookie year could determine how far the Colts are able to get this season, but a solid Week 1 against the Seahawk’s 5th ranked rush defense would go a long way to proving he’s the real deal.

How to Watch Seahawks vs Colts

Seahawks vs Colts Information
Team Seattle Seahawks vs Indianapolis Colts
Location Lucas Oil Stadium in Indianapolis, Indiana
Time Sunday, September 12, 2021; 1:00 PM ET
How to watch FOX

More Games to Watch on Week 1

Play Fantasy Football, Here!

Bet $20 Win $200 in Free Bets

21+ CO, VA, MI Only | Terms and conditions apply

Claim Now
Image for Mike Lukas


Mike Lukas

1210 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

More info on Mike Lukas
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks

© Rebel Penguin ApS 2023 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.