Seattle Seahawks vs Indianapolis Colts Predictions, Odds & Picks

Seahawks vs Colts Week 1

  • Seahawks QB Russell Wilson is now working with a new OC, Shane Waldron
  • Colts QB Carson Wentz is fresh off a recent foot injury and subsequent surgery
  • These two haven’t played since 2017 when the Seahawks beat the Colts, 46-18

Bet on Seattle Seahawks vs Indianapolis Colts, Here!

Seahawks vs Colts Odds

Odds taken 3 Sep, 2021 from DraftKings Sportsbook

Team Point Spread Odds
Seattle Seahawks -2.5
Indianapolis Colts +2.5

Here is your chance to win a $600! Sign-up to our NFL Pick ’em Contest!

Seahawks vs Colts Predictions and Picks

Seahawks vs Colts LIVE Odds!

The odds for this match are provided by DraftKings Sportsbook Click on the odds below to head to DraftKings and place a bet!

Odds provided by DraftKings Sportsbook

21+ | NJ, WV, PA, IN, IL, CO, IA, TN, MI, VA only | T&C apply

Might want to take the well-oiled Seahawks machine in Week 1 since, even if Wentz can play, it might take him a few weeks to bang the rust off his surgically repaired foot.

Our Pick:

Seahawks -2.5

Bet on Seattle Seahawks vs Indianapolis Colts, Here!

The Seattle Seahawks have a healthy QB in Russell Wilson who is now working with a new OC Shane Waldron who will make it his job to game plan around his speedy WRs DK Metcalf and Tyler Lockett so long as DC Ken Norton’s upgraded defense can keep these Colts off the field.

Indianapolis Colts QB Carson Wentz is fresh off a recent foot injury and subsequent surgery, but he says he will be ready to go in Week 1 (expect a bit of rust, maybe?), while defensively, rookie end Kwity Paye will be trying to sack Wilson with the help of veteran DT DeForest Buckner in front of a hometown crowd.

These two cross-conference enemies have met each other 12 prior times, with the Indianapolis Colts winning 7 of those games and the Seattle Seahawks winning 5 of the games.

Can the Seahawks Offense Return After Struggling in 2020?

The Seattle Seahawks front office decided to change offensive coordinators this offseason after ranking a dismal 17th in the league last year under OC Brian Schottenheimer, and now the team’s offense will be run by former Rams passing game coordinator Shane Waldron.

The hope is that Waldron can better utilize the playmakers he has at his disposal now, such as wide receivers DK Metcalf and Tyler Lockett and tight end Gerald Everett plus running back Chris Carson who gives the offense a powerful backfield twist.

Despite their relative lack of offensive production last year the Seahawks were still able to put almost 29 points per game on the board, so imagine what Wilson, last season’s 9th most productive QB, can score once an upgraded game plan is put in place.

Can the Colts Turn All That Roster Talent into Wins?

Ever since the Colts franchise QB Andrew Luck retired before the 2019 season, the Indianapolis Colts have been searching for a replacement under center, trying anyone from Jacoby Brissett to veteran Philip Rivers in that spot with questionable results.

Now the team is counting on oft-injured veteran Carson Wentz to hurl footballs for them and already he is having to start the new season on the mend, now at the end of rehabbing his surgically repaired foot.

With a top-10 defense last season and talent on offense like wide receivers TY Hilton and Michael Pittman Jr. plus tight end Jack Doyle and running back Jonathan Taylor, this Colts team needs a leader like a healthy Wentz to put it all together on the field and turn that into wins.

Editor’s Picks

Seahawks Key Player: (WR) DK Metcalf

This will be Seahawks receiver DK Metcalf’s third NFL season and so far he has not disappointed, the perfectly sculpted Mississippi alum with the size and the speed to make a huge impact on the field.

Last year Metcalf had his best season yet, posting 83 catches on 129 targets for over 1300 yards and 10 touchdowns proving to be a speedy receiver who tends to get open deep and who can earn extra yards after the catch.

QB Russell Wilson and Metcalf are developing a fantastic connection so expect this season to top even the last, especially if Seattle’s 12th ranked run game can continue to offer a decent counterbalance to the absolute passing threat this combo poses.

Colts Key Player: (RB) Jonathan Taylor

Last season as a rookie, Colts running back Jonathan Taylor made quite an impression, running the ball 232 times for 1,169 yards and 11 touchdowns while catching 36 passes for another 300 yards and a touchdown.

That type of production from a rookie is rare, so the Colts know that what they have in Taylor is special, and now that the entire league understands what a powerful runner this Wisconsin alum is expect them all to game plan a way to stop him.

Whether Taylor and offensive coordinator Marcus Brady can top that rookie year could determine how far the Colts are able to get this season, but a solid Week 1 against the Seahawk’s 5th ranked rush defense would go a long way to proving he’s the real deal.

How to Watch Seahawks vs Colts

Seahawks vs Colts Information
Team Seattle Seahawks vs Indianapolis Colts
Location Lucas Oil Stadium in Indianapolis, Indiana
Time Sunday, September 12, 2021; 1:00 PM ET
How to watch FOX

More Games to Watch on Week 1

Bet on Seattle Seahawks vs Indianapolis Colts, Here!

More NFL Predictions & Odds

2022 NFL Draft Running Backs Prospects, Predictions, and Picks
2022 NFL Draft Running Backs Prospects, Predictions, and Picks
The 2022 NFL Draft will feature some top talent at the running back position, so here we break down the best.
21 March | 07:12 | Mike Lukas
Aaron Rodgers Trade Rumors, Predictions, Odds, Pick
Aaron Rodgers Trade Rumors, Predictions, Odds, Pick
Trade rumors regarding Aaron Rodgers are floating around so we share our predictions, odds, and pick of which team he will play for next.
7 March | 05:04 | Mike Lukas
NFL History of the Los Angeles Rams vs Cincinnati Bengals: Wins, Losses, and Other Helpful Trends
NFL History of the Los Angeles Rams vs Cincinnati Bengals: Wins, Losses, and Other Helpful Trends
Let’s go over the NFL History of the Los Angeles Rams vs the Cincinnati Bengals including the wins, losses, and other helpful trends to know before you place your bets.
8 February | 05:29 | Mike Lukas

Mike Lukas

Expert on NFL

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]