When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

No. 5 Washington vs. No. 20 USC Picks, Predictions & Odds

Written by: Grant Mitchell
Published November 3, 2023
10 min read

The two top teams in the Pac-12 are headed on a crash course as No. 5 Washington prepares to take on No. 20 USC in Los Angeles this weekend.

Reigning Heisman winner Caleb Williams has not been his best lately and is about to go toe-to-toe with this year’s odds-on favorite, Washington QB Michael Penix Jr. This will be the first time the two schools have met since 2019 when Washington beat their rival at home, 28-14.

Here, we will go over the betting odds and share our insights and best bets for the Pacific Coast matchup.

No. 5 Washington vs. No. 20 USC Odds

Washington is a slight road favorite despite being a perfect 8-0 and USC struggling with its last three opponents.

TeamSpreadMoneylinePoints Total
No. 5 Washington-3 (-105)-155Over 76.5 (-112)
No. 20 USC+3 (-115)+130Under 76.5 (-108)

Odds from DraftKings Sportsbook. Get $200 in bonus bets when you wager just $5 using our exclusive link.

Washington vs USC Predictions

Even though Oregon is the sixth-ranked team in the country, Washington and USC have the two best conference records at 5-0 and 5-1.

USC barely survived 3-5 California in an epic 50-49 battle a week ago. That put an end to their two-game losing streak, during which they fell to No. 21 Notre Dame and No. 14 Utah.

Williams is second in the country in passing and averages 294 yards per game. He’s also tossed 25 touchdowns and only four interceptions and has the ninth-best QBR. Running back MarShawn Lloyd is the Pac-12’s leading rusher at 85.1 yards per game and has gained 7.7 yards per carry to go with eight touchdowns.

USC has no problems scoring and puts up 45.9 per game, which is the second-most in Division-I behind only LSU. Their defense, however, is a total mess and ranks 109th in points allowed per game (32.6). They’re 70th in third-down defense and 120th in red zone defense, allowing scores on nearly 94% of opponents’ entries.

Penix Jr. leads the Huskies on the other side of the matchup. He’s +280 to win the Heisman at DraftKings at the time of writing and leads all of college football with 368.1 passing yards per game, along with 24 touchdowns, six interceptions, and the sixth-best QBR.

Washington is ninth in the country in scoring offense (40.4 points per game) and, like USC, has an underrated running game. Dillon Johnson came up huge in a 36-33 win against Oregon a few weeks ago with 100 yards and a touchdown on 20 carries.

Where Washington separates itself from the Trojans is on defense. It is 33rd in points allowed per game (20.6) and 31st in the red zone, allowing scores on 76.9% of opponents’ entries.

No. 5 Washington vs. No. 20 USC Betting Preview

There were suggestions that Williams could end his season prematurely to prepare for the NFL Draft, but that seems unlikely at this stage. Even though his numbers haven’t been as gaudy, he still threw for 628 yards and two touchdowns in his last two games.

That said, Penix Jr. is playing at an even better level than Williams and gets to face a much easier defense. The Trojans made the stale offenses of Notre Dame and Utah look dominant and then surrendered a season-high 49 points to a Cal team that had scored more than 40 against only one Power Five opponent.

USC is also 2-7 ATS, though Washington is only 3-4-1.

No. 5 Washington vs. No. 20 USC Picks & Predictions

No. 5 Washington -3 (-105 at DraftKings)

We like Washington to cover the field goal here. Their passing concepts and offensive talent make them virtually unguardable, especially by such a porous USC secondary. They can also get crucial stops on defense, whereas USC cannot.

Place your bets at DraftKings Sportsbook using our exclusive link. 

Over 76.5 (-108 at DraftKings)

A total of 76.5 is outrageous, but it fits the bill. Both of these teams want to turn the game into a shootout as quickly as possible and won’t rest until they do. We believe both will succeed and both teams have a great chance to crack 40 points, which leads us to believe in the over.

Bet on College Football at DraftKings - Wager $5 and get $200 in bonus bets! 

No. 5 Washington vs. No. 20 USC Betting Promos

Take a look at the top sportsbook promos and grab a bonus when you bet on Washington vs. USC.

How to Watch No. 5 Washington vs. No. 20 USC

  • Where: Los Angeles Memorial Coliseum, Los Angeles, CA

  • When: Saturday, Nov. 4 7:30/10:30 p.m. PT/ET

  • TV: ABC

More NCAAF Week 10 Stories

Image for Grant Mitchell

AUTHOR

Grant Mitchell

480 Articles

Grant is a sports and sports betting journalist who prides himself on delivering breaking news and insightful analyses of the industry. Grant graduated from Virginia Tech in 2021 and is feverishly pursuing his ambitions in the sports betting field.

In his free time, Grant can be found passionately watching sports, doing a workout, or searching for adventure with his friends.

More info on Grant Mitchell
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork
WorldSportsNetwork

© Rebel Penguin ApS 2024 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.