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Detroit Lions vs Arizona Cardinals Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
12 min read
Lions Vs Cardinals Week3
  • The Lions’ defense seems to be failing them, allowing opponents to score 69 points
  • Looks like the Arizona Cardinals have figured out their offense behind QB Kyler Murray
  • Last season, the Lions and Cards tied in Week 1, each scoring 27 total points after OT

Lions vs Cardinals Odds

Team Point Spread Odds
Detroit Lions +5.5
Arizona Cardinals -5.5


Odds from DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or check out more offers and promo codes for the best online sportsbooks.

Lions vs Cardinals Predictions and Picks

The Lions are having a horrible time on defense and the Cardinals are enjoying a swell of offense thanks to QB Murray and new Arizona WR DeAndre Hopkins, so expect this one to not go so well for Detroit.


Cardinals -5.5 (-110)

How to Watch Lions vs Cardinals

Lions vs Cardinals Information
What Detroit Lions vs Arizona Cardinals
Where State Farm Stadium in Glendale, AZ
When Sunday, September 27, 2020; 4:25 PM ET
How to watch FOX

It would appear that head coach Matt Patricia’s 0-2 Detroit Lions are heading in the wrong direction, especially given that their defense has allowed opponents to score a total of 69 points in just two games, something that will not result in many victories.

Then there are the Arizona Cardinals, who added star deep threat receiver DeAndre Hopkins to their roster in the offseason and have now become the offensive powerhouse that everyone expected from the duo of QB Kyler Murray and head coach and offensive coordinator Kliff Kingsbury.

These two NFC rivals have met each other a total of 67 times, with the Arizona Cardinals winning 28 of those matchups and the Detroit Lions winning 33 of them with 6 ties, as well.

Can the Lions’ Defense Stop a Powerful Cardinal Attack?

The Lions are not measuring up on the defensive side of the ball, which is odd considering their head coach, Matt Patricia, has always been considered a bit of a defensive guru.

Currently, the Lions defense has allowed the fifth-most yardage in the first two weeks, with opponents gaining 425 offensive yards per game while only two other teams have allowed their opponents to score more points per game, the Lions giving up 34.5 points per matchup.

Can’t win in the NFL if the opponent outscores you, so the Lions and defensive coordinator Cory Undlin had the best figure out ASAP what ails them on that side of the ball.

Editor’s Picks

Can Cardinals QB Kyler Murray Continue to Develop?

It’s only his second NFL season, but Cardinals QB Kyler Murray is fast becoming one of the better at his position, so far in 2020 posting a 2-0 record and completed 66.7 percent of his passes, both numbers up from this time last season.

Murray had a great Week 2, completing 26-of-38 passes for 286 yards and a touchdown with an interception while carrying the ball 8 times for 67 yards and 2 more touchdowns.

Accurate and powerful arm, ability to run and avoid tackles, high-level football IQ, Murray has it all, and it stands to reason he will continue to develop as an NFL QB as the 2020 season progresses.

Lions Key Player: (WR) Kenny Golladay

One of the best WRs on the Lions is third-year player Kenny Golladay, who last season led the league with 11 touchdown receptions off 65 catches for 1190 yards.

Golladay is listed as questionable for Week 3 with a hamstring issue, an injury that can slow a speedy receiver like him down and limit his overall effectiveness.

If the Lions and QB Matthew Stafford hope to score their first victory of the 2020 season against the Cardinals, then Golladay has to show up reasonably healthy and able to stretch out Arizona’s secondary.

Cardinals Key Player: (WR) Larry Fitzgerald

Everybody in the football world is throwing their Cardinal’s attention to newly acquired receiver DeAndre Hopkins, but do not make the mistake of forgetting about the star WR they already had on their roster, veteran playmaker Larry Fitzgerald.

Last week against the Washington Football Team, for example, Larry Fitz caught 100% of the 7 passes he was targeted with for 50 yards, while in Week 1 he caught four out of five that he was targeted for and posted 34 yards of offense.

With Fitzgerald looming as a constant deep threat, opposing defenses have to pick their poison between he and Hopkins, so having him on the roster makes everyone else look and play better, yet another reason this 2020 Cardinals team could be a postseason contender.

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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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