Best 49ers vs. Jaguars Prop Bets NFL Week 10

One of the more fascinating games this week comes from two teams coming off of a bye week: the San Francisco 49ers and Jacksonville Jaguars. The 49ers are in the middle of a three-game losing streak, while the Jaguars have a hold on the AFC South.

Below are the three best bets for this matchup.

San Francisco 49ers vs. Jacksonville Jaguars

Pick: Travis Etienne Under 3.5 Receptions (-120) at DraftKings

In this matchup, Etienne will take on a 49ers defense that allows about five receptions for 34 yards and 0.12 touchdowns per game to opposing running backs.

This season, Etienne has lived on the hook of this 3.5 line, catching three passes in a game four times and four passes twice, and the other two games were a five-catch day (Week 1) and two catches (Week 2). 

Etienne is their primary pass-catcher out of the backfield. Still, he’ll also face 49ers run defense that’s been somewhat generous to running backs, allowing over four yards a carry but just 64 yards per game. They’ve allowed 93 or more in two of their last three games. 

The 49ers perform worse against wide receivers, allowing 12 receptions for 175 yards and a touchdown per game, so Lawrence may have more looks to them and further down the field. 

We think Etienne finishes with three or fewer receptions here. 

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Pick: Trevor Lawrence Under 16.5 Rushing Yards (-115) at DraftKings

The 49ers added a new pass rusher in Chase Young to go alongside Nick Bosa, so Lawrence will be contending with that all afternoon. 

This season, Lawrence has 216 rushing yards, averaging 27 per game. However, the 49ers don’t exactly allow quarterbacks to pick up yardage on the ground. 

The 49ers allow four carries and 15 yards rushing per game to opposing quarterbacks. Also, that 15-yard average includes two games where Joshua Dobbs had 48, and Joe Burrow somehow managed 43. 

If you take those games away, the average drops to less than five yards per game. 

This will be more of a pocket-focused game for the former No. 1 overall pick. 

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Pick: Trevor Lawrence Over 0.5 Interceptions (-119) at Caesars

Sticking with Lawrence, we think he’s good for an interception in this one. This season, he has four interceptions but 11 turnover-worthy plays. Against the 49ers, he’ll face a defense that allows 26 completions on 39 attempts to opposing quarterbacks for 244 yards, 1.25 touchdowns, and 1.38 interceptions. 

The 49ers have just two games without an interception and have four games with multiple. 

We expect the 49ers to get back on track here, and the added pass rush from Young should help make the day more difficult for Lawrence. 

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*All statistics courtesy of Pro Football Focus.

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