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San Francisco 49ers vs Seattle Seahawks Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
12 min read
49ers Vs Seahawks 2020 11 01
  • The 49ers are 4-3 after easily taking care of the New England Patriots in Week 7
  • Seahawks QB Russell Wilson threw 3 picks in AZ last week in his first loss of the season
  • These NFC West rivals met twice last year; SEA 27-SF 24 (OT) and SF 26-SEA 21

49ers vs Seahawks Odds

Take a look at our latest NFL predictions and picks!

Team Point Spread Odds
San Francisco 49ers +3
Seattle Seahawks -3


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49ers vs Seahawks Predictions and Picks

Don’t expect Russell Wilson to play poorly two games in a row, so these banged-up 49ers might struggle to outscore them, even with the spread, so take the Seahawks and give up the points.


Seahawks -3 (-110)

How to Watch 49ers vs Seahawks

49ers vs Seahawks Information
What San Francisco 49ers vs Seattle Seahawks
Where Levi’s Stadium in Santa Clara, CA
When Sun, November 1, 2020; 4:25 PM ET
How to watch FOX

The San Francisco 49ers are 4-3 and in the NFC West basement, so a Week 8 win against their divisional rivals would go a long way, but injuries have decimated their roster and depending on which next man up show up in Week 8 this could be a struggle for QB Jimmy Garoppolo’s crew.

It was a rare sight in Week 8, Seahawks losing their first game of the season and QB Russell Wilson throwing three interceptions and losing in overtime to the Arizona Cardinals, who they were expected by most football ‘experts’ to beat.

The two NFC West rivals have played each other 43 times (including 1 postseason game), with the Seattle Seahawks winning 26 of those matchups and the San Francisco 49ers winning 17 of them.

Can Niners QB Jimmy Garoppolo Show Up, Unlike Against the Patriots?

Sure, the 49ers got the Week 6 win over the New England Patriots by the lopsided score of 33-6, but all of the four touchdowns the offense scored were on the ground and with field goals, with not one-off QB Jimmy Garoppolo’s arm.

Garoppolo completed 20-of-25 in that outing for 277 yards and zero touchdowns, but he also threw two interceptions and ended up with a passer rating of 79.5, a low number that typically would apply to whichever quarterback who lost the game, not the 33-6 victor.

While it’s great to have a rushing attack that can score, without a passing game to balance that out the offense becomes one-dimensional and easier to defend against, something that can’t happen if San Francisco hopes to steal a Week 8 win off Seattle.

Check out our Week 8 bonuses!

Can the Seahawks Perform Well with So Many Injuries to Their Roster?

Currently, the Seahawks have ten players who are listed as questionable for Week 8 due to various injures suffered in Week 7, with too many of them being starters and playmakers whose absence will make a Week 8 victory even tougher.

Among them is star safety Jamal Adams, who is dealing with a groin situation, and running back Chris Carson, whose injured foot is still an issue for him, and both of them plus the eight others who are questionable will be a game-time decision to be made by HC Pete Carrol and his coaching crew.

The 49ers may be last in the division, but it would be a mistake to underestimate their 8th ranked rushing attack or their defense, ranked 5th, so these banged-up players will most likely push through the pain and get playing time, but how effective they can be at this point is the question.

Editor’s Picks

49ers Key Player: (WR) Deebo Samuel

Right now, San Fran’s second-year wide receiver Deebo Samuel is averaging 11.6 yards per catch and has held onto 72.7 percent of the balls thrown his way, not bad numbers for a player new to the NFL.

For the last two games, Samuel has caught every ball he’s been targeted with from QB Jimmy Garoppolo, catching 6 passes for 66 yards and a touchdown in Week 6 and 5 catches for 65 yards in Week 7.

For Niners HC Kyle Shanahan’s team to get the win here, it will take Samuel stepping up and giving his QB some open targets, which might help him build back some confidence after the two picks he threw in last week’s outing.

Seahawks Key Player: (QB) Russell Wilson

Not too sure what happened to QB Russell Wilson last week, but he played poorly and his Seattle Seahawks got their first loss, so it stands to reason that he needs to do well if they expect a victory in this one.

Even when Wilson plays less than stellar – a kind way to describe the three interceptions he threw in that Week 7 loss to the Arizona Cardinals – he still delivers decent numbers, completing 33 passes in that one for 372 yards and 3 touchdown passes on top of rushing 6 times for another 84 yards.

Expect Wilson to show up in Week 8 with a huge chip on his shoulder, and if his teammates can heal up by Sunday enough to support him on the field, a win looks likely for this playoff-worthy Seattle team against a 49ers franchise that’s still mending its wounds.

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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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