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Buffalo Bills vs Arizona Cardinals Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
12 min read
Bills Vs Cardinals 2020 11 15
  • The Buffalo Bills have found their franchise QB, Josh Allen, and sit atop the AFC East
  • Cardinals QB Kyler Murray is excellent, and Arizona is staying relevant in the NFC West
  • The last time these two teams played was in 2016, final score BUF 33 – ARI 18

Bills vs Cardinals Odds

Check out the latest NFL predictions for Bills vs Cardinals game!

Team Point Spread Odds
Buffalo Bills +2
Arizona Cardinals -2


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Bills vs Cardinals Predictions and Picks

This should be one of the better matchups of Week 10, but in the end, the Bills should be able to outscore the Cardinals for the win.


Bills +2 ( -110)

How to Watch Bills vs Cardinals

Bills vs Cardinals Information
What Buffalo Bills vs Arizona Cardinals
Where State Farm Stadium in Glendale, Arizona
When Sun, November 15, 2020; 4:05 PM ET
How to watch CBS

The Buffalo Bills took care of the tremendous Seattle Seahawks by ten points in Week 9, final score 44-34, with QB Josh Allen completing 31 passes for 415 yards and 3 touchdowns with no interceptions, his second 400+ yard game of the season and his career, a sure sign that this offense is to be taken seriously.

The Cardinals quarterback Kyler Murray had a terrific game in Arizona’s Week 9 loss to the Dolphins, at least in terms of stats, completing 21-of-26 for 283 yards and 3 touchdowns with no interceptions, but the Cards were kept scoreless in the fourth quarter and their defense let Miami score ten for the win, Arizona now 5-3 and in 2nd place of the NFC West.

These two teams have only met each other 11 other times, with the Arizona Cardinals winning 4 of those games and the Buffalo Bills winning 7 of them.

Can Bills Josh Allen Continue His Quarterback Evolution?

When you look at Bills QB Josh Allen’s progression as a player since his rookie season in 2018, you can see he has become a more accurate passer, his completion percentage evolving from 52.8 to 58.8 to now 68.9, plus his TD percentage has grown from 3.1 to 4.3 to 6.0 this season.

This growth is obvious on the field and has translated into team wins, with Allen’s record over the last two seasons now at 17-8, with the Buffalo Bills postseason chances firmly in most playoff discussions.

Allen is Buffalo’s franchise QB, and if he can keep his interceptions low – he has five picks so far in 2020 – then his evolution at this critical position will continue to impress HC Sean McDermott and OC Brian Daboll.

Can the Cardinals Defense Put Pressure on Bills QB Allen?

One of the unsung heroes of the Cardinals defense is linebacker Haason Reddick, a one-man wrecking crew already responsible for 5 sacks, 9 quarterback hits, 3 passes defended and 31 total tackles, with 9 of those for a loss.

The one stat that Bills QB Josh Allen is weak on is sacks – so far, his O-line has allowed him to be sacked 20 times this season, which is ninth-most in the NFL right now.

If the Cardinals rushing attack can put pressure on Allen, he is still young enough to make mistakes when he is feeling rushed, so that could be a way to help neutralize a kid that has been lighting up the scoreboard this season.

Editor’s Picks

Bills Key Player: (WR) Cole Beasley

Slot receiver Cole Beasley is in his second season with the Bills, but he spent the first seven of his seasons with the Dallas Cowboys.

This year, Beasley has caught 44 passes for 533 yards and 2 touchdowns, solid numbers for any slot receiver, and his 12.1 yards per catch is a career-high for the young veteran.

The role of the slot is to pull attention away from the deep threats, and the Bills have two excellent playmakers at that position – John Brown and Stefon Diggs, a unit that is currently ranked seventh most productive in the NFL.

Cardinals Key Player: (LB) Isaiah Simmons

Rookie linebacker Isaiah Simmons has been an effective addition to the Cardinals defense, already contributing to a unit that is ranked 19th in production in the league after allowing opponents to gain 370 yards per game.

So far in his rookie campaign, Simmons has posted an interception, 2 passes defended, and 16 total tackles, numbers that are sure to increase as the former Clemson Tiger gets acclimated to the higher quality play of the NFL.

Simmons was a first-round pick (8th overall) and the 6’4” 238 pounder joins a crew of fellow linebackers in Arizona that include Reddick (see above), De’Vondre Campbell, Jordan Hicks and Kylie Fitts, all young playmakers ready to make their name in the league.

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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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