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Arizona Cardinals vs Seattle Seahawks Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
6 min read
Cardinals Vs Seahawks 2020 11 19
  • The Arizona Cardinals have won four of their last five matchups and sit at 6-3
  • The Seattle Seahawks have dropped three of their last four games and are also 6-3
  • They already played each other this season, the Cards beat the Seahawks in OT, 37-34

Cardinals vs Seahawks Odds

Team Point Spread Odds
Arizona Cardinals +3.5
Seattle Seahawks -3.5


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Cardinals vs Seahawks Predictions and Picks

Until the Seahawks fix whatever is failing their 32nd ranked defense, it might be tough to bet on them, especially against the best overall offense in the league right now in the Cardinals.


Cardinals +3.5 (-110)

How to Watch Cardinals vs Seahawks

Cardinals vs Seahawks Information
What Arizona Cardinals vs Seattle Seahawks
Where CenturyLink Field in Seattle, WA
When Thursday, November 19, 2020; 8:20 PM ET
How to watch FOX / NFLN

The Arizona Cardinals seem to be on a roll, having won four of their last five matchups with a bye thrown in between, and quarterback Kyler Murray and his team are now 6-3 and battling for the top spot of their division, facing, in Week 11, a team that’s in a similar situation and also needs the win.

The Seahawks, on the other hand, have lost three of their last four games (and that includes a loss to these Cards in Week 7) and, though they also sits at 6-3, Seattle has more to prove here since QB Russell Wilson has looked too fallible during this losing streak – nothing a win over these pesky Cardinals won’t cure.

These two NFC West franchises have met each other 43 other times, with the Seattle Seahawks winning 21 of those games and the Arizona Cardinals winning 21 of the games, plus they have tied once.

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Can the Cardinals Offense Continue to Gel?

The Arizona Cardinals are one of those NFL teams whose head coach also runs the offense, and Kliff Kingsbury is in charge of the number one producing offense in the league right now so he is definitely doing something(s) right.

One reason is QB Kyler Murray, in just his second NFL season under center in Arizona, a 23-year-old who plays with the skill of a veteran, right now with 212 completions for 2,375 yards and 17 touchdowns with 8 interceptions, as well as 87 carries for 604 yards and 10 more touchdowns.

Murray currently leads the league with a 6.9 yards per carry average, though he is not the only rushing threat the Cardinals have on the roster, see also running backs Chase Edmonds and Kenyan Drake, who are lighting up the league this season.

Can Seattle’s QB Russell Wilson Stop the Bleeding?

The Seattle Seahawks were rolling to a 5-0 start to the season, mainly on the arm and legs of QB Russell Wilson, who looked to be a serious MVP candidate whose team would most certainly play football in January.

But dropping three out of four games (including one already to these division-rival Cardinals) has been the result, if only partially, of Wilson having some bad games like during the last two weeks when he has thrown two interceptions in each of those games.

Wilson is talented and in the prime of his career, so he will most certainly bounce back in time for the postseason, but whether his Seahawks go to the playoffs as the kings of the NFC West or as Wildcards could be determined by how this Week 11 matchup results.

Editor’s Picks

Cardinals Key Player: (RB) Kenyan Drake

This is Kenyan Drake’s fifth season in the NFL, and the speedy running back is just now getting back into the groove he had a few seasons ago down in Miami, where he began his pro career back in 2016 with the Dolphins.

Now he is out of the Arizona backfield and making heads turn averaging 4.5 yards per carry, with 135 rushes this season for 612 yards and 4 touchdowns on top of 8 catches for 38 yards, a dual-threat who is becoming a key to the Cardinals run game.

Drake shares snap with a talented running backs room that includes Chase Edmonds, Jonathan Ward and Eno Benjamin, but he can become the key to any game the way he did in the team’s Week 10 win over the Bills when he ran 16 times for 100 yards but no touchdowns.

Seahawks Key Player: (WR) Tyler Lockett

One of the advantages of being on the same team as a playmaker like WR D.K. Metcalf is that defenses tend to double- and triple-team him, and that leaves some extra space in the secondary for all the other players on the team to maneuver in.

Which is what receiver Tyler Lockett has been doing, and having an impressive season as a result of the Metcalf-bump, so far with 58 catches off 79 targets for 681 yards and 7 touchdowns, impressive numbers that will only increase as the season progresses.

Lockett led the team in catches and receiving yards in their loss last week to the Rams, snagging 5 balls for 66 yards but no touchdowns off 9 targets, a game where nobody caught any touchdowns and the offense only managed a field goal in the entire second half.

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Mike Lukas

Sports Betting & Gambling Industry Analyst

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Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager.
Nationality: American
Education: N/A
Favourite Sportsbook: bet365 Sportsbook
Favourite Casino: Caesars Palace Casino
23 years
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