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Kansas City Chiefs vs Buffalo Bills Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
12 min read
Chiefs Vs Bills 2020 10 19
  • The Chiefs got their first loss in Week 5, surprisingly to the Raiders by a score of 32-40
  • Also coming off a big loss are the Buffalo Bills, with QB Josh Allen not throwing well
  • These two teams last played each other in 2017, final score Buffalo 16, Kansas City 10

Chiefs vs Bills Odds

Check out our NFL predictions and picks for this early Monday Night Football game!

Team Point Spread Odds
Kansas City Chiefs -4
Buffalo Bills +4


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Chiefs vs Bills Predictions and Picks

Both of these teams are coming off a disappointing loss, but that was quarterback Patrick Mahomes and his Chiefs first lost since the tenth week of last season, so it was a fluke that will be rectified against this Bills team whose young QB just had his confidence shaken.


Chiefs -4 (-110)

How to Watch Chiefs vs Bills

Chiefs vs Bills Information
What Kansas City Chiefs vs Buffalo Bills
Where Bills Stadium in Orchard Park, NY
When Mon, October 19, 2020; 5:00 PM ET
How to watch FOX/NFLN

Not sure how the Kansas City Chiefs blew their lead two-score lead in Week 5 to lose to the less talented Las Vegas Raiders, but they did, and now they have to face a fifth-ranked Buffalo offense, not as scary when yours is ranked third like in the case of Patrick Mahomes.

The Buffalo Bills defense has slipped down into the middle of the NFL pack, now allowing opponents to gain 371 yards per game and score over 28 points each time, but its QB Josh Allen and the offense who need to step and make up for the off two-interception outing that helped lead to a Week 5 loss.

These two AFC cross-divisional rivals have met each other a total of 48 times (including 3 postseason games), with the Buffalo Bills winning 26 of those games and the Kansas City Chiefs winning 21 games, plus one tie.

Look for the best NFL week 6 bonuses, here!

Can the KC Chiefs Defensive Line Make Life Difficult for Josh Allen?

Bills QB Josh Allen has been sacked 10 times already this season, or twice a game, which isn’t a crazy amount but still shows he is vulnerable to attack.

With pressure on him from the KC Chiefs D line – DE Tanoh Kpassagnon, LDT Chris Jones, RDT Derrick Nnadi, and RDE Frank Gore – chances are he could make the same throwing mistakes in this one.

The Chiefs defense is ranked 10th best in sacks at this point in the season with 13 of them so far, so they can definitely become a huge factor in this Week 6 matchup with the Bills.

Editor’s Picks

Can Bills QB Josh Allen Recover From Week 5 and Regain Momentum?

This is Bills QB Josh Allen’s third NFL season, and in each year, he has shown development that has culminated in 2020 that includes a completion percentage of almost 70.

His Bills are 4-1 and currently lead the shaky AFC East, so a win here against the Chiefs would help his team solidify their divisional dominance and prove they can win the big games against opponents who are typically tough to beat.

Last week, Allen threw two interceptions, bringing his seasonal total to just 3, so it’s not time to panic just yet, but instead time to return to the basics that have him as the second most productive QB in the league right now behind only the injured Dak Prescott.

Chiefs Key Player: (DE) Frank Clark

Frank Clark is a problem if you are the quarterback he is playing against, so far this year with 3 sacks to himself plus 4 quarterback hits, all in five games, the Chiefs defensive end now playing in his sixth NFL season, all in KC.

In the team’s loss to the Raiders in Week 5, Clark had a sack and a tackle, his production typically one of the main reasons the Chiefs can stay close in any game.

Against the Bills, Clark will be a key component of the pass rush against a young QB in Josh Allen who just threw two interceptions in a Week 5 loss, so putting extra pressure on him could make a huge difference in how effective he is capable of playing.

Bills Key Player: (WR) Stefon Diggs

For the first five seasons of his NFL career, WR Stefon Diggs suited up for the Minnesota Vikings and made a name for himself there, and now his home is in Buffalo and the young veteran is making his presence known again.

This season Diggs has caught 36 passes for 509 yards and 2 touchdowns, production that has not only helped his Bills to a 4-1 record but has also given his young QB Josh Allen plenty of confidence as he continues to develop at the NFL level.

Diggs has had two 100+ yard games in a row, but with no touchdowns in those outings, something that would be key to a win against this high scoring Chiefs team that can keep up with the best of them.

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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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