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San Francisco 49ers vs New Orleans Saints Predictions, Odds & Picks

Written by: Mike Lukas
Updated October 14, 2022
12 min read
49ers Vs Saints 2020 11 15
  • The San Francisco 49ers must start winning if they expect to play football in January
  • Drew Brees and his New Orleans Saints humiliated the TB Bucs in Week 9, 38-3
  • These two NFC teams met last year in December; the final score was SF 48 – NO 46

49ers vs Saints Odds

Find the latest NFL predictions and picks for 49ers vs Saints game.

Team Point Spread Odds
San Francisco 49ers +9
New Orleans Saints -9


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49ers vs Saints Predictions and Picks

After seeing what the Saints did to the Bucs last week, it seems to reason they will do the same or worst to these banged-up 49ers and easily cover this spread at home.


Saints -9 (-110)

How to Watch 49ers vs Saints

49ers vs Saints Information
What San Francisco 49ers vs New Orleans Saints
Where Mercedes-Benz Superdome in New Orleans, LA
When Sun, November 15, 2020; 4:25 PM ET
How to watch FOX

The San Francisco 49ers are truly banged up with six former Pro Bowlers currently on Injured Reserve, plus their QB Jimmy Garoppolo and his bum ankle are out, so this team is basically a poster child for the Next Man Up campaign of 2020.

Those of us who expected a competitive game between the Saints and Bucs in Week 9 got a huge surprise as New Orleans flew to an easy 38-3 win over the extremely talented (and GOAT enhanced) Tampa squad, so it will be a much easier walk in the park in Week 10 for quarterback Drew Brees against these injury-plagued Niners.

These two cross-divisional rivals have met each other 77 prior times (including 1 postseason game), with the New Orleans Saints winning 26 of those games and the San Francisco 49ers winning 49, plus there have been 2 ties.

Find the best promo codes and our Week 10 bonuses, here!

Can the Injured 49ers Even Compete Anymore?

Of the fifteen San Francisco players who are listed on injured reserve right now, a half dozen of them are Pro Bowl-caliber, meaning this team is having to compete with mostly their second string, which is never a solid recipe for victory.

Some of the big names the team has lost so far this season – DE Dee Ford (neck), C Ben Garland (calf), WR Jalen Hurd (knee – ACL), TE George Kittle (foot), and RB Raheem Mostert (ankle).

This is a next-man-up league that endures zero excuses, so this team has to get it done regardless of the cards they have been dealt, but against this fiery Saints team, it could be more difficult than ever to find a W.

Can Saints ‘Elderly’ QB Drew Brees Continue His Excellence?

In the NFL, 41-years old is considered elderly, but Drew Brees seems ageless on the field right now leading his talented Saints to a 6-2 record and first place in the NFC South division a game ahead of the team they just crashed last week, the Buccaneers.

Brees has put up some impressive numbers this year – he has completed 211-of-285 passes for 2,120 yards and 17 touchdowns with just 3 interceptions and currently leads the league in completion percentage with his 74.0.

The Saints and Brees are notoriously rusty at first during a season, but they look to be in full swing after that lopsided Week 9 divisional win they just achieved, so expect them to have another big game against this battered and bruised 49ers team as they get themselves ready for the postseason.

Editor’s Picks

49ers Key Player: (QB) Nick Mullens

Never easy for a backup QB to jump in midseason and take over the reins of the offense, but that is what Nick Mullens has been asked to do with starter Jimmy Garoppolo now out and on the IR list for the foreseeable future.

Mullens is in his third NFL season and has a 4-7 record in the games he has started, but he has shown himself to be a reliable QB with an accurate arm, completing 68.4 percent of his passes this year.

This 49ers team is so banged up that nobody expects much from them at this point in the season, and that lack of pressure could be just what Mullens needs to step in and make do with the players he does have and help find his team at least a couple more wins in 2020, though most likely not in this one.

Saints Key Player: (WR) Michael Thomas

Saints star receiver Michael Thomas was finally back after dealing with an ankle injury and in Week 9 he caught 5 balls for 51 yards in the Saints big win over the Buccaneers, a good sign for a playmaker who has had trouble getting onto the field.

HC Sean Payton says Thomas is on a “pitch count,” meaning he will be used in a limited capacity to make sure his ankle doesn’t have to endure too many reps, proof that his return to health is prioritized.

Thomas had some other issues earlier in the season involving him punching a teammate in practice, but he is too valuable a star on the field to not be used and highly targeted, especially as they run to the postseason begins.

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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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