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Best College Football Bets Week 4 | CFB Picks & Predictions

Written by: Richard Janvrin
Updated October 14, 2022
15 min read
Cfb Best Bets This Week

After an offensive explosion in Week 3 by the Ohio State Buckeyes, we’re taking immediate notice of them for two of the best bets for the College Football Week 4 slate.

Simply put, these two bets should make you plenty of money this weekend, even with them being from the same game.

In addition to these, we head west and look at their opponent from last week, the Toledo Rockets, taking on the San Diego State Aztecs.

Let’s dive in.

Ohio State vs Wisconsin

Time: Saturday, 7:30 PM ET, ABC

Pick: Ohio State -17.5 (-110) at Caesars

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The Wisconsin Badgers defense is always critically acclaimed as a top-tier unit. And, well, according to Pro Football Focus, they’re the 15th and 12th best coverage and pass-rushing unit in the country.

While this may be true, their secondary is pretty beatable, with cornerback Ricardo Hallman as the biggest challenge.

Wide receiver Jaxon Smith-Njigba only played 14 passing down snaps in Week 3, but that was likely just a way for him to get warmed up for this Big 10 showdown, as he should play quite a bit.

Hallman has been solid this season, but we also need to consider the Badgers schedule, which includes games against Washington State, Illinois State, and New Mexico.

The Buckeyes have several weapons in Smith-Njigba, Emeka, Egbuka, Marvin Harrison Jr., and even tight end Cade Stover to throw at the Badgers.

Not to mention, the Buckeyes run for over 6.2 yards per carry, with Miyan Williams, TreVeyon Henderson, and Dallan Hayden leading a three-back committee.

We don’t want to take anything away from the Badgers. Still, their defense isn’t quite there to avoid some big plays from the Buckeyes. Their offense, led by quarterback Graham Mertz, simply can’t compete in a shootout.

This is quite a bit of points to lay when we’ve seen the Buckeyes struggle against teams like Notre Dame, but this offense is clicking well right now.

Earn yourself a risk-free bet of up to $1,250 when you sign up at Caesars Sportsbook today using our link. 

Ohio State vs Wisconsin

Time: Saturday, 7:30 PM ET, ABC

Pick: Under 57.5 (-110) at BetMGM

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While we think the Buckeyes will get their points in this one, the circumstances in which we believe the game will go can only lead to bad things for Mertz and the Badgers.

On the ground, the Badgers average 6.2 yards per carry with Braelon Allen, Isaac Guerendo, and Chez Mellusi, but how long can we expect the Badgers to rely on them if the Buckeyes go up by 10, 14, 17, or 20+?

Simply put: You can’t.

Ohio State wins this one 35-14.

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San Diego State vs Toledo

Time: Saturday, 3:30 PM ET, FS1

Pick: Under 45.5 (-110) at FanDuel

If you like offense, well, then this one isn’t for you. This game will be decided in the trenches and with the rushing attacks.

Heading into this one, the Toledo Rockets project as the better of these two teams, with quarterback Dequan Finn scoring four rushing touchdowns and adding five more through the air on a 59.5% completion rate.

The Rockets average 6.5 yards per carry on the ground, with four different running backs having at least 16 carries.

Finn does like to target his receivers, Jerjuan Newton and DeMeer Blankumsee. This could be an avenue for more points against a so-so Aztecs coverage unit, but again, the trenches are where this one will be won.

The Rockets will have to deal with Justus and Jonah Tavai in the middle of the defensive line, threatening both Rockets guards and their center.

Neither team performs all that well offensively in general, though. The Aztecs rank 116th in the nation with 297.7 offensive yards per game, and the Rockets are better, sure, but are still 83rd with 385.

If neither team hits 20 points, it wouldn’t be a shock.

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College Football Best Bets Explained

College Football betting is one of the most exciting forms of sports wagering. Not only are we getting a first-hand look at potential future NFL talent, but it’s not uncommon for games to have combined point totals nearing the 100s.

Here at WSN, we analyze each matchup closely, looking at the offense and defense for both teams, examining the key players, and monitoring injury reports for the most up-to-date information.

Money Line

The moneyline is wagering on which team you think will win the game outright. These are notated by “+” and “-” odds. The “+” indicates the underdog, whereas the “-” is for the favored team.


Think of the point spread as a system to make teams as evenly matched as possible. Almost all games will have a team that is superior to the other, and the point spread accounts for that. For example, if a team is +20 when the game begins, you can view that team as leading 20-0 when the real-life score is 0-0.


Also known as over/under betting, totals allow you to bet on the combined point total in a contest. There are two lines you can bet on—whether the total will go over or under the projection.

Prop Bets

There are three types of prop bets—team, game, and player. Examples of these include how many punts will be made by a team, what color Gatorade is dumped at the end of the Super Bowl, or how many passing yards a quarterback will have.

These are micro-events that happen within the game.


A parlay allows you to wager on two more contests on a single ticket. When doing so, not only will the parlay consider the odds from both contests individually, but the odds also reflect the risk assessment.

With parlays, all contests on a ticket must succeed for the ticket to win, which causes added risk.


Futures allow you to wager on events that will resolve at a later date. Popular examples of these include Super Bowl winners, NBA Finals winners, MVP awards, and more. These wagers happen before and during the season, with the odds shifting daily.

Why Should You Trust Us?

I’ve been a College Football and sports betting analyst since 2018 when the Professional and Amateur Sports Protection Act was overturned. While I can’t guarantee a win on every wager, you can trust that my analysis comes from studying all possible nuances of each game.

How We Make Our Picks?

When making College Football betting picks, there are many things to look for.

  • Quarterback play
  • Strength of each team
  • Offensive line vs. Defensive line
  • Possible NFL talent
  • Wide receiver vs. Cornerback matchups
  • And much more

Where Can You Bet on College Football?

Online college Football betting is legal in the following states:

(* = pending)

What Are the Best Sports Books to Bet on College Football?

The best sportsbook to bet on College Football is the one with the best odds. With all our picks, we look at all legal online sportsbooks to find the best odds for you so you can avoid needing to line shop yourself. You can browse our list of the best sportsbooks and the best bonuses at WSN to see for yourself!

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Richard Janvrin

567 Articles

After graduating from the University of New Hampshire with a BA in Journalism, Richard Janvrin has been covering iGaming and sports betting since December 2018. Richard has covered betting at Bleacher Report, Gambling.com, The Game Day, Forbes, and more.

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