Champions League Best Bets: Matchday Seven, January 21 - January 22

• The league phase of the 2025/26 Champions League continues this week

• Eighteen matches will be held across Europe on Tuesday and Wednesday 

• Inter vs Arsenal is one of the standout fixtures on the horizon

Champions League Matchday Seven Odds

The odds for the Champions League Matchday Seven contained in this article are taken from the bet365 sportsbook, one of our top-rated soccer betting sites.

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Inter vs. Arsenal

Under 2.5 Goals (-111) at bet365

After six rounds of fixtures in the league phase, Arsenal are the only team still boasting a 100 percent record.

Mikel Arteta’s men have been magnificent up to now and they will surely seal a place in the round of 16 this week.

This trip to San Siro will not be easy, though. Inter, who were Champions League runners-up last term, are sixth in the standings having won four of their six games up to now.

Critics of the Nerazurri would point out that the fixture list was kind to them early on, but there is no doubt that Inter are a fine side on their day.

These two teams have the best defensive records in the competition, so this could be a low-scoring match.

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Real Madrid vs. Monaco

Real Madrid to Score in Both Halves (-138) at bet365

Real Madrid had to go through the knockout phase play-offs last season, a fate they will be aiming to avoid this time around.

Madrid are currently in the top eight on goal difference alone, so there is still work to be done for the 15-time kings of the continent.

Monaco, for their part, need another win to be sure of their participation in the play-offs, but they are obviously huge underdogs in this one.

With Kylian Mbappe back in the fold after injury, the Blancos can score either side of the break at the Estadio Santiago Bernabeu.

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Marseille vs. Liverpool

Marsille or Draw (-111) at bet365

Liverpool are having a difficult season in the Premier League, but this can still be a successful season for Arne Slot’s side.

A Champions League triumph would represent a fantastic outcome in the Dutch manager’s second campaign at the helm.

Liverpool will want to avoid the knockout phase play-offs, but to do so they must rise one more place from ninth.

Marseille will not make things easy for the Reds on matchday seven, however. The Stade Velodrome is a tough place to go and a win for the French side would move them level on points with Liverpool.

With their home fans behind them, Marseille can avoid defeat against the six-time European champions.

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Slavia Prague vs. Barcelona

Barcelona -1 Handicap (-111) at bet365

Barcelona are still kicking themselves for failing to reach the Champions League final last season.

Hansi Flick’s team are desperate to make amends in 2025/26, but defeats by Paris Saint-Germain and Chelsea have shown that Barca must improve in this tournament.

Things have been going well for the Blaugrana in La Liga of late, and they now need to bring that form to the European stage.

Slavia Prague will struggle to contain Flick’s men here. Barcelona have the offensive quality to triumph in the Czech Republic.

A win by a two-goal margin or more is well within reach for the Catalonian club.

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Sporting CP vs. Paris Saint-Germain

Over 3.5 Goals (+150) at bet365

Paris Saint-Germain are seeking to defend their crown in this season’s Champions League, having lifted the trophy for the first time in 2025.

Only Arsenal and Bayern Munich are above the holders in the table, so PSG are well positioned to advance directly to the round of 16.

Indeed, a victory in Lisbon this week might be enough to guarantee them a top-eight berth with a game to spare.

PSG’s matches so far have contained an average of 4.5 goals per 90 minutes, so we should expect more entertainment when they face Sporting CP.

Offenses are likely to get the better of defenses in this one.

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Copenhagen vs. Napoli

Both Teams to Score (-134) at bet365

Antonio Conte is widely regarded as one of Europe’s best coaches, yet he has a curiously poor record in continental competition.

Despite being the reigning Serie A champions, Napoli are struggling to get going in the Champions League.

Conte’s side are in danger of crashing out of the tournament before the knockout stage. They are currently 23rd, with a top-24 finish required for the play-offs.

Copenhagen are 24th ahead of matchday seven, so this feels like a winner-takes-all encounter in the Danish capital.

Copenhagen can pierce a Napoli backline which has not been as convincing in Europe as it usually is in Italian domestic soccer.

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How to Watch Champions League Matchday Seven

• Location: Europe

• Dates: Tuesday, January 21 - Wednesday, January 22 

• How to Watch: Paramount+